4 research outputs found
Complications of Mesenteric Vein Thrombosis: Heterozygous Factor V Leiden Mutation Leads to Pulmonary Embolism in a Patient With Post–Bowel Resection Surgery
No full textABSTRACT It is critical to recognize pulmonary embolism as soon as possible in patients who have gastrointestinal problems pre‐ and post‐surgery. Even in the absence of conventional risk factors, the Factor V Leiden mutation emphasizes the importance of a thorough thrombophilia assessment. To effectively manage and prevent thrombotic episodes, prompt anticoagulant medication and genetic screening for family members are essential
Association of latent autoimmune diabetes of adults with type 3 polyglandular autoimmune syndrome—a diagnostic challenge
No full textAutoimmune polyendocrine syndromes (APS) encompass multiple endocrine gland insufficiencies associated with autoimmune disease. This case report underscores the importance of recognising the association between latent autoimmune diabetes of adults (LADA) and type 3 polyglandular syndrome. A 42-year-old man belonging to Rawalpindi, Pakistan, presented to the outpatient department (OPD) of Ali Medical Centre, Islamabad, in January 2023 with the complaints of extreme thirst and frequent urination. The patient reported consistently raised appetite and eating four to five meals a day along with abrupt weight loss, dry mouth, fatigue occasional dizziness, and dyspnoea. He was diagnosed with type 3 polyglandular syndrome with association of LADA. Daily administration of 10 units of glargine insulin, along with six units of rapid-acting insulin, was prescribed. The patient's HbA1c level reduced in a few months after successive follow-up.
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Frequency of DÉJÀ VU Experience and Its Relationship with Stress in Students of The Medical University of Islamabad
No full textObjective: This research aims to evaluate the frequency of déjà vu experience in medical students and its relationship with stress along with different prognostic factors that lead to déjà vu experience.
Methods: A descriptive cross-sectional study was conducted at Foundation University Islamabad over 4 months from May 2023 to August 2023. The sample size (239) was calculated using open Epi software with a previous prevalence of 67%. Stratified random sampling was used to select students. Data was collected through a questionnaire containing demographic variables from a validated déjà vu inventory and stress tool. Analysis was done on a validated déjà vu inventory and perceived stress scale 10. SPSS 26 was used to assess the relationship between stress and the frequency of déjà vu using the chi-square test, with statistical significance at p<0.05.
Results: 89.2% of the participants reported that they had experienced this sensation at least once in their life. The most popular ways this feeling happened were in a certain place or a certain situation. The association between stress and Déjà vu experiences was found to be significant(p-value 0.012)
Conclusion: 89.2% of the participants reported that they had experienced Déjà vu sensation at least once. There was a significant association between stress among medical university students and Déjà vu experience.
Keywords: Déjà vu, Stress, Familiarity, Sensation, Epilepsy, Dopamine
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study
No full textBackground: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. Methods: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. Results: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33–4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76–2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6% ) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42–0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14–0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11–0.44) and SSI (OR 0.21 95% CI 0.09–0.45). Conclusion: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. Trial registration: NCT02179112
