3 research outputs found
Dialogical Intervention of Material Agency in Atiq Rahimi’s Earth and Ashes
No full textThis paper examines how material agency embodied by the land, ruins, silence, and objects involves in a dialogical relationship with human trauma and memory in Atiq Rahimi’s Earth and Ashes. The novella portrays Dastageer, an elderly survivor of a bombed Afghan village, journeying with his grandson Yassin through a devastated landscape. The narrative employs evocative imagery and second-person address to interweave the responses of the terrain into the emotional and psychological trajectories of the protagonists. This study relies on trauma theory and eco-critical concepts for the analysis of selected literary text. The research highlights how the environment actively speaks through Dastageer’s reveries and Yassin’s innocent misinterpretation of deafness believing that others have lost their voices rather than his hearing that poignantly illustrates a material voice in rupture. The land bears witness to atrocity and become a counterpart to human testimony in the novel. The novel’s sparse yet charged prose transforms landscape into a co-author of memory, grief, and unspoken history
The Role of Decompressive Craniectomy in Traumatic Brain Injury: An Institutional Experience in a Tertiary Care Hospital
No full textAbstract: Background: Traumatic brain injury can damage the brain on permanent basis, to protect the brain Decompressive can play a pivot role to protect from secondary brain injury.
Objective: To assess the prognosis and functional outcomes in role of decompressive craniectomy in traumatic brain injury in tertiary care hospital.
Materials and Methods: This study conducted at Jinnah Post Graduate Medical Institute (JPMC) in Karachi from January 2018 to April 2022, comprises of 304 patients who underwent decompressive craniectomy following traumatic brain injury, specifically those with traumatic mass lesions. Our aim was to gain insight into their functional outcomes over a period of six months, utilizing the Glasgow Outcome Score at intervals of one month, three months, and six months, employing the chi-squared test, to identify any parameters that correlated with poor outcomes. This helped us discern potential factors contributing to unfavorable results.
Result: The current study comprised 304 individuals, with a median age of 48 years (IQR: 43-53). The majority of patients (66.1%) were older than 45 years. The median time since injury was 10 hours (IQR: 7-13.75). The median GCS score was (IQR: 5-7). The majority of patients had ASDH + Contusion (44.1%) and ASDH (42.1%) on CT scans. In our study, 38.5% of patients had a good outcome, whereas 61.5% had a poor outcome. The outcome was significantly associated with gender (p=0.033), age group (p <0.001), time since injury (p<0.001), GCS score (p<0.001), midline shift (p<0.001), mass lesion volume (p<0.001), and CT findings (p=0.002).
Conclusion: Decompressive craniectomy stands as a pivotal intervention in the management of severe traumatic brain injury (sTBI) patients grappling with traumatic mass lesions
ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming
No full textAbstractBoolean modelling of biological networks is a well-established technique for abstracting dynamical biomolecular regulation in cells. Specifically, decoding linkages between salient regulatory network states and corresponding cell fate outcomes can help uncover pathological foundations of diseases such as cancer. Attractor landscape analysis is one such methodology which converts complex network behavior into a landscape of network states wherein each state is represented by propensity of its occurrence. Towards undertaking attractor landscape analysis of Boolean networks, we propose an Attractor Landscape Analysis Toolbox (ATLANTIS) for cell fate discovery, from biomolecular networks, and reprogramming upon network perturbation. ATLANTIS can be employed to perform both deterministic and probabilistic analyses. It has been validated by successfully reconstructing attractor landscapes from several published case studies followed by reprogramming of cell fates upon therapeutic treatment of network. Additionally, the biomolecular network of HCT-116 colorectal cancer cell line has been screened for therapeutic evaluation of drug-targets. Our results show agreement between therapeutic efficacies reported by ATLANTIS and the published literature. These case studies sufficiently highlight the in silico cell fate prediction and therapeutic screening potential of the toolbox. Lastly, ATLANTIS can also help guide single or combinatorial therapy responses towards reprogramming biomolecular networks to recover cell fates.</jats:p
