8,189 research outputs found
Kinetic modeling of 5-FU-loaded SLNs.
No full textThe present study aimed to prepare solid lipid-based nanoparticles (SLNs) using Precirol® ATO 5 as solid lipid and Poloxamer 188 and Tween 80 as surfactant and co-surfactant respectively, and SLNs-derived gel for sustained delivery, enhanced in-vitro cytotoxicity, enhanced cellular uptake of 5-FU and enhanced permeation of 5-FU across the skin. The 5-FU-loaded SLNs were prepared by the hot melt encapsulation method and converted into SLN-derived gel using a gelling agent (Carbopol 940). The 5-FU-loaded SLNs had a particle size in the range of 76.82±1.48 to 327±4.46 nm, zeta potential between -11.3±2.11 and -28.4±2.40 mV, and entrapment efficiency (%) in range of 63.46±1.13 and 76.08±2.42. The FTIR analysis depicted that there was no chemical interaction between 5-FU and formulation components. Differential scanning calorimetric analysis showed thermal stability of 5-FU in the nanoparticles and powdered X-ray diffraction analysis revealed successful incorporation of 5-FU in nanoparticles. The in-vitro release study of 5-FU-loaded SLNs showed biphasic release behavior with initial burst release followed by sustained release over 48 hr. The 5-FU-loaded SLNs showed a greater cytotoxic effect on skin melanoma (B16F10 cells) and squamous cell carcinoma (A-431 cells) as compared to free 5-FU drug solution after 48 hr. Flow cytometry and fluorescence microscopy displayed enhanced quantitative and qualitative cellular uptake of SLNs. The SLNs formulation showed acceptable safety and biocompatible profile after an acute toxicity study in Wistar rats. Moreover, ex-vivo permeation studies depicted 2.13±0.076 folds enhanced flux of 5-FU-loaded SLN derived gel compared to 5-FU plain gel, and skin retention studies revealed target efficiency (%) 2.54±0.03 of 5-FU-loaded SLN derived gel compared to 5-FU plain gel.</div
Rheograms of 5-FU plain gel and 5-FU-loaded SLNs gel.
No full textRheograms of 5-FU plain gel and 5-FU-loaded SLNs gel.</p
Permeation analysis of 5-FU-loaded SLNs gel and 5-FU plain gel.
No full textPermeation analysis of 5-FU-loaded SLNs gel and 5-FU plain gel.</p
<i>Ex-vivo</i> permeation analysis of 5-FU-loaded SLNs gel and 5-FU plain gel.
No full textEx-vivo permeation analysis of 5-FU-loaded SLNs gel and 5-FU plain gel.</p
Physicochemical characteristics of 5-FU-loaded SLNs.
No full textPhysicochemical characteristics of 5-FU-loaded SLNs.</p
PENGGUNAAN CERITA DALAM MENJELASKAN HADIS PADA KITAB AL-MAWA<’IZ{ ’US{FU<RIYYAH
No full textKitab al-Mawa>’iz{ al-’Us{fu>riyyah adalah kitab hadis yang dikaji di sebagian
pondok pesantren, kitab tersebut termasuk kitab hadis sekunder dengan model
pembukuan arba’ina>t. Isi dari kitab al-Mawa>’iz{ al-’Us{fu>riyyah berisi syarah hadis
berupa cerita-cerita (kisah), sama halnya di kitab lain salah satunya kitab
s{ah{i>h{ain (Bukhari dan Muslim) mengisahkan dalam matan hadis bertema
keutamaan sahabat. kitab tafsir al-Qur’an ada menceritakan Nabi terdahulu
bahkan kisah israiliyyat dan umat zaman dulu sebelum Nabi Muhammad SAW.
Permasalahan tersebut kemudian menjadikan penelitian ini bertujuan bagaimana
penggunaan dalam menjelaskan hadis di dalam kitab al-Mawa>’iz{ al-’Us{fu>riyyah
dan apakah ada kesamaan (hubungan) atau perbedaan antara hadis dan cerita di
dalam kitab tersebut.
Jenis penelitian yang dilakukan adalah penelitian kepustakaan (library research)
dengan metode kualitatif deskriptif dan analisis content. Data yang dipakai
dalam penelitian ini penulis mengambil dua jenis yaitu data primer dan sekunder
dilanjutkan menginterpretasikan sehingga bisa menarik suatu kesimpulan.
Pengumpulan data semuanya dikumpulkan baik dari primer dan sekunder
kemudian dianalisis untuk menemukan hasil yang dimaksud.
Hasil dari penelitian menunjukan bahwa kitab al-Mawa>’iz{ al-’Us{fu>riyyah
dikarang oleh Muhammad bin Abi Bakar dikenal dengan nama us}fu>riyyah.
Penyusunannya dengan mengumpullkan 40 buah hadis, dalam 40 (bab) hadis
tidak menuliskan bab-bab tertentu secara lansung, tetapi menyebutkan al-h{a>di>s\u
awwalu, al-ha>di>s\u s\a>ni dan seterusnya. Dalam kitab tersebut pengarang juga
menuliskan syarahnya berisi cerita-cerita yang memperkuat hadis yang sedang
dijelaskan. Penggunaan cerita dalam menjelaskan hadis pada kitab ’Us{fu>riyyah
cerita-cerita yang diambil oleh pengarangnya dengan mencantumkan kisah yang
memiliki hubungan dengan hadis sebagai esensi utama. Kemudian ceritanya
digunakan sebagai menggugah pembaca menjadi semangat dan bisa membantu
memahami esensi hadisnya. Sehingga antara keduanya memiliki kesesuaian.
Fungsi cerita dalam kitab ini disajikan dengan kisah/cerita sebagai kedudukan
pensyarah hadis
Fu Describing About the Author Himself: A Focus on Ban Gu "You tong fu"
No full textFrom Later Han dynasty onwards, the number of fu describing about the author himself has increased. There are several possible reasons for this, but the most important reason is probably that there was no other genre through which one could express oneself except for fu in this period. For instance, the fiveword poetry was still in the middle way of establishing its own style at that moment. Moreover, in Former Han, there were few opportunities for authors to talk about themselves in detail in fu, because the main readers were emperors and kings of countries. In Later Han, the readers had become more diverse. That is probably the reason why more fu began to mention about the authors themselves in this period. Ban Gu (32-92), who is a representative scholar of Later Han and also a man of letters, expressed his aim by writing "You tong fu". Its main content is that though one's encounter with a disaster or felicity is not always derived from our behavior, we have to have a strong will and take action to overcome disasters. This idea is supported by Ban Gu's experiences of not attaining his aim. Such experiences are common in Chinese authors. One of the earliest examples is Chu Ci. Also, Chu Ci is the one of the origins of fu. It is surprising that authors expressed things about themselves mostly in fu describing journeys. It may be easier to understand this tendency if we think they substituted the heaven wander in Chu Ci with a ground journey. Chu Ci was a model for authors to express their aim which could not come true, even if the journey on the ground and the wander in heaven are different
TEM analysis of 5-FU-loaded SLNs at (A) 7500X magnification (scale bar 400 nm) and (B) 20000X magnification (scale bar 100 nm).
No full textTEM analysis of 5-FU-loaded SLNs at (A) 7500X magnification (scale bar 400 nm) and (B) 20000X magnification (scale bar 100 nm).</p
Online Iterative Adaptive Dynamic Programming Approach for Solving the Zero-Sum Game for Nonlinear Continuous-Time Systems with Partially Unknown Dynamics
No full textThe current study presents an online iterative adaptive dynamic programming approach to resolve the zero-sum game (ZSG) for nonlinear continuous-time (CT) systems containing a partially unknown dynamic. The Hamilton-Jacobian-Issacs (HJI) equation is solved along the state trajectory according to the value function approximation and the policy improvement online. Relaxed dynamic programming is utilized to ensure the algorithm’s convergence. Model and costate networks were established to conduct the method. Computational simulations are performed to present the efficiency of the algorithm.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Control & Simulatio
Note of congratulations from Jack Huang to Dr. Frank Fu, January 1, 1983
No full textA note of congratulations to Dr. Frank H. Fu (Fu Haojian) from Springfield College Alum, Jack Huang, Class of 1936, dated January 1, 1983. The card has country lane scene on the front, with a tree with pink leaves, a buttfly, and a tree with its leaves still green. There is the roof of a house just visible over the hill. It also says Congratulations. Inside is short message.Mr. Huang wrote a short personal note congratulating him for his efforts and the recent recognition by then President Ronald Reagan, or the actor as he refers to him, and saying how proud the Chinese are of him. An author of 17 textbooks and more than 100 journal articles, Frank H. Fu, G’73, DPE’75, has worked across the world in China, Canada, and the United States. Throughout his career, he has received many distinguished honors, including the Medal of Honor in 2009 by the SAR Government of Hong Kong.
Fu has held positions at institutions such as the Chinese University of Hong Kong and Springfield College, where he served as director of the International Center starting in 1978. Five years later, Fu returned to Hong Kong, but has since remained actively involved with Springfield College, participating in talks on the campus and even hosting a gathering of nearly 60 alumni in Hong Kong.
Currently, Fu is the associate vice president of Hong Kong Baptist University, where he also works as the director of the Dr. Stephen Hui Research Centre of Physical Recreation and Wellness. In addition, Fu is president of the Society of Chinese Scholars on Exercise Physiology and Fitness, chairperson of Hong Kong Coach Education Committee, a research fellow of the Research Consortium of SHAPE America, and an international fellow of the National Academy of Kinesiology
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