1,721,087 research outputs found
Mu-ming Poo: China Brain Project and the future of Chinese neuroscience
No full textAbstract
Among several major frontier science and technology projects soon to be initiated by the Chinese government, China Brain Project (on ‘Brain Science and Brain-like Intelligence Technology’ (CBP)) has attracted much attention. Mu-ming Poo, Director of the Institute of Neuroscience (ION) and Center for Excellence in Brain Science and Intelligence Technology of Chinese Academy of Sciences (CAS), is currently also the Executive Associate Editor of NSR. He has played a key role in the strategic discussion and planning for CBP. In a recent interview with NSR, Poo discussed his view on the goals and contents of CBP, as well as recent developments and future prospects of neuroscience in general. Throughout his research career that spanned over four decades, Poo has made seminal contributions to several areas in neuroscience. He reminisced during the interview on his own career path, as well as his experience and thoughts on building the research infrastructure for Chinese neuroscience.</jats:p
Retrograde Signaling in the Development and Modification of Synapses
No full textFitzsimonds, Reiko Maki, and Mu-ming Poo. Retrograde Signaling in the Development and Modification of Synapses. Physiol. Rev. 78: 143–170, 1998. — Retrograde signaling from the postsynaptic cell to the presynaptic neuron is essential for the development, maintenance, and activity-dependent modification of synaptic connections. This review covers various forms of retrograde interactions at developing and mature synapses. First, we discuss evidence for early retrograde inductive events during synaptogenesis and how maturation of presynaptic structure and function is affected by signals from the postsynaptic cell. Second, we review the evidence that retrograde interactions are involved in activity-dependent synapse competition and elimination in developing nervous systems and in long-term potentiation and depression at mature synapses. Third, we review evidence for various forms of retrograde signaling via membrane-permeant factors, secreted factors, and membrane-bound factors. Finally, we discuss the evidence and physiological implications of the long-range propagation of retrograde signals to the cell body and other parts of the presynaptic neuron.</jats:p
REVIEW
No full text Mu-ming Poo: The Janusian Neurobiologist. MVA: A promising viral vector platform for Asian Infectious Diseases. International, Scientific, Environmental and Analytical Technology Business Event at Suntec, Singapore. </jats:p
Scientific leap-forward in the critical period: the thirteenth Five-Year Plan of the Chinese Academy of Sciences (CAS)
No full text- …
