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The three-dimensional microstructure of the liver. A review by scanning electron microscopy
The improvement in scanning electron microscopy (SEM) techniques has permitted us
to describe the microstructure of the liver. By SEM, the liver peritoneal surface
is composed of flat mesothelial cells possessing microvilli and cilia. Hepatic
sinusoids connect the portal vessels with the terminal branches of the hepatic
vein (central veins). Endothelial cells of the portal space arteries are
elongated and arranged longitudinally, while those of the central and portal
veins are polygonal and flattened, possessing microvilli. The sinusoidal
endothelial cells show both small fenestrations (sieve plates), up to 200 nm in
diameter, and large ones, up to 1 micron. Within the sinusoids are seen bridging
structures, covered by fenestrated endothelium, seeming to have a fibrillar core.
Kupffer cells resemble macrophages, showing microvilli, blebs, lamellipodia and
filopodia. Within the Space of Disse are seen the fat-storing cells, having
laminar dendritic projections. The polyhedral liver cell faces the Space of Disse
(vascular pole) or faces an adjacent hepatocyte (biliary pole). Vascular facets
are evenly covered by microvilli. Biliary facets show a central longitudinal
depression, bordered by microvilli (bile hemicanaliculi). Canaliculoductular
junction and bile duct epithelia show blebs, microvilli and cilia. Up to now,
fetal liver and liver pathology have been scarcely investigated by SEM: in the
future, they can be successfully approached by three-dimensional studie
Advances in Microanatomy of Cells and Tissues: Biophysical and Biochemical Correlates. Marcello Malpighi Series: Vol. 7. in ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY
The Three-Dimensional Organization of the Human Fetal Liver as Seen by Scanning Electron Microscopy
Studio al microscopio elettronico a scansione dello sviluppo del fegato umano fra la VI e la XXII settimana di vita intrauterina
Insegnamento multimediale in Anatomia. Elaborazione di un software didattico sperimentale
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