2,576 research outputs found
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study
No full textIn AIDS Clinical Trials Group protocols 384, A5095, and A5097s, we characterized relationships between 22 polymorphisms in CYP2B6, ABCB1, and CYP3A5; plasma efavirenz exposure; and/or treatment responses. A stepwise logistic regression procedure selected polymorphisms associated with reduced drug clearance adjusted for body mass index and the composite CYP2B6 516/983 genotype. Relationships between selected polymorphisms and treatment responses were characterized by competing risk methodology. Association analyses involved 821 individuals (317 for pharmacokinetics and 643 for treatment response). Models that included CYP2B6 516/983 genotype best predicted pharmacokinetics. Slow-metabolizer genotypes were associated with increased central nervous system events among white participants and decreased virologic failure among black participants.Heather J. Ribaudo, Huan Liu, Matthias Schwab, Elke Schaeffeler, Michel Eichelbaum, Alison A. Motsinger-Reif, Marylyn D. Ritchie, Ulrich M. Zanger, Edward P. Acosta, Gene D. Morse, Roy M. Gulick, Gregory K. Robbins, David Clifford, and David W. Haa
Repositioning the graphic designer as researcher
No full textIn academic terms, the discipline of graphic design is relatively young. Consequently the position of the discipline within academic territory, and the role of the designer, continue to be debated. In part, these debates have been a product of attempts to define and defend the discipline’s borders from within, in order to establish a sense of the role of graphic design and the graphic designer as commensurate with other disciplines both within and beyond art and design. In recent years graphic designers have variously been defined as ‘authors’, ‘producers’ and ‘readers’, yet none of these definitions seem to have provided any kind of productive or lasting impact within the academy. This paper suggests that rather than continue to seek territorial definitions and positions from within, it could be more productive to look beyond the confines of the discipline. Gaining a broader, interdisciplinary perspective on, and understanding of, qualitative research methods from other disciplines may enable the graphic designer to more fully position his or her practice within the wider academy. Such a perspective could help facilitate the repositioning and redefinition of the graphic designer as ‘researcher’ - a move that would be productive in relation to the future development of postgraduate research within the discipline
The effect of alternative permutation testing strategies on the performance of multifactor dimensionality reduction
No full textAbstract Background Multifactor Dimensionality Reduction (MDR) is a novel method developed to detect gene-gene interactions in case-control association analysis by exhaustively searching multi-locus combinations. While the end-goal of analysis is hypothesis generation, significance testing is employed to indicate statistical interest in a resulting model. Because the underlying distribution for the null hypothesis of no association is unknown, non-parametric permutation testing is used. Lately, there has been more emphasis on selecting all statistically significant models at the end of MDR analysis in order to avoid missing a true signal. This approach opens up questions about the permutation testing procedure. Traditionally omnibus permutation testing is used, where one permutation distribution is generated for all models. An alternative is n-locus permutation testing, where a separate distribution is created for each n-level of interaction tested. Findings In this study, we show that the false positive rate for the MDR method is at or below a selected alpha level, and demonstrate the conservative nature of omnibus testing. We compare the power and false positive rates of both permutation approaches and find omnibus permutation testing optimal for preserving power while protecting against false positives. Conclusion Omnibus permutation testing should be used with the MDR method.</p
Faculty Opinions recommendation of XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits.
No full textComputational Approaches for Aggregating, Analyzing, and Visualizing Multi-Modal Feature Data.
No full textDiscussion of a Genome‐Wide Association Approach to Determine HIV‐1 Set Point in African Americans
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Embracing Complexity: Searching for Gene-Gene and Gene Environment Interactions in Genetic Epidemiology
No full textInterview with Alison Frank, September 25, 2009
No full textInterview Themes: How Frank chooses research topics (00:50)
Aspects of her training as a historian Frank found useful (07:00)
Books that have inspired and informed Frank's work (11:11)
On the role of area studies for scholarship on East-Central Europe (14:00)
"Internationalizing" the history of East-Central Europe (19:30)
Advice to young historians/scholars working on the region (22:11)Interview with Alison Frank, John L. Loeb Associate Professor of the Social Sciences at Harvard University. Interview conducted in Ithaca, NY on September 25, 2009. Professor Frank is the author of a number of articles and an excellent book on the oil industry in the Habsburg Monarchy entitled Oil Empire: Visions of Prosperity in Austrian Galicia. She is now working on a project on the coastline of Austria-Hungary.1_9lz5ekh
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