633 research outputs found
Supplementary_Figure_legends_20180804 – Supplemental material for Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway
No full textSupplemental material, Supplementary_Figure_legends_20180804 for Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway by Masanobu Tsubaki, Tomoya Takeda, Mikihiro Matsumoto, Natsuki Kato, Shota Yasuhara, Yu-ichi Koumoto, Motohiro Imano, Takao Satou and Shozo Nishida in Tumor Biology</p
メディシナルフラワーの機能性成分を指標とした品質評価―茶花, 蝋梅花および蓮花―
No full text学位の種類：薬学 学位授与年月日：平成29年3月21日 主査：村岡, 修 教授 報告番号：乙第690号 学内授与番号：薬第134号
Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase, Tomoya Takeda, Masanobu Tsubaki, Toshiki Kino, Misa Yamagishi, Megumi Iida, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Takao Satou, Shozo Nishida, Chemico-Biological Interactions, Volume 251, 5 May 2016, Pages 26-33, https://doi.org/10.1016/j.cbi.2016.03.018 掲載
Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway, Tomoya Takeda, Masanobu Tsubaki, Toshiki Kino, Ayako Kawamura, Shota Isoyama, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishida, International Journal of Oncology, April 1, 2016 Pages:2704-2712, https://www.spandidos-publications.com/ijo/48/6/2704/abstract, https://doi.org/10.3892/ijo.2016.3470 掲載
Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model, Tomoya Takeda, Masanobu Tsubaki, Kotaro Sakamoto, Eri Ichimura, Aya Enomoto, Yuri Suzuki, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishida, Toxicology and Applied Pharmacology, Volume 306, 1 September 2016, Pages 105-112, https://doi.org/10.1016/j.taap.2016.07.005掲載application/pdfdoctoral thesi
新規NIK阻害剤mangiferinの細胞死誘導効果及びその機序の解明
No full text学位の種類：薬学 学位授与年月日：平成29年9月13日 主査：西田, 升三 教授 報告番号：乙第699号 学内授与番号：薬第139号
Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase, Tomoya Takeda, Masanobu Tsubaki, Toshiki Kino, Misa Yamagishi, Megumi Iida, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Takao Satou, Shozo Nishida, Chemico-Biological Interactions, Volume 251, 5 May 2016, Pages 26-33, https://doi.org/10.1016/j.cbi.2016.03.018 掲載
Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway, Tomoya Takeda, Masanobu Tsubaki, Toshiki Kino, Ayako Kawamura, Shota Isoyama, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishida, International Journal of Oncology, April 1, 2016 Pages:2704-2712, https://www.spandidos-publications.com/ijo/48/6/2704/abstract, https://doi.org/10.3892/ijo.2016.3470 掲載
Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model, Tomoya Takeda, Masanobu Tsubaki, Kotaro Sakamoto, Eri Ichimura, Aya Enomoto, Yuri Suzuki, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishida, Toxicology and Applied Pharmacology, Volume 306, 1 September 2016, Pages 105-112, https://doi.org/10.1016/j.taap.2016.07.005 掲載application/pdfdoctoral thesi
酸化ストレスがもたらす皮膚恒常性機能障害と高安定型アスコルビン酸誘導体の改善作用に関する研究
No full text学位の種類：薬学 学位授与年月日：平成28年12月15日 主査：村岡, 修 教授 報告番号：乙第685号 学内授与番号：薬第132号
Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase, Tomoya Takeda, Masanobu Tsubaki, Toshiki Kino, Misa Yamagishi, Megumi Iida, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Takao Satou, Shozo Nishida, Chemico-Biological Interactions, Volume 251, 5 May 2016, Pages 26-33, https://doi.org/10.1016/j.cbi.2016.03.018 掲載
Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway, Tomoya Takeda, Masanobu Tsubaki, Toshiki Kino, Ayako Kawamura, Shota Isoyama, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishida, International Journal of Oncology, April 1, 2016 Pages:2704-2712, https://www.spandidos-publications.com/ijo/48/6/2704/abstract, https://doi.org/10.3892/ijo.2016.3470 掲載
Mangiferin, a novel nuclear factor kappa B-inducing kinase inhibitor, suppresses metastasis and tumor growth in a mouse metastatic melanoma model, Tomoya Takeda, Masanobu Tsubaki, Kotaro Sakamoto, Eri Ichimura, Aya Enomoto, Yuri Suzuki, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishida, Toxicology and Applied Pharmacology, Volume 306, 1 September 2016, Pages 105-112, https://doi.org/10.1016/j.taap.2016.07.005掲載application/pdfdoctoral thesi
Society and Individual in the Early Nishida Philosophy
No full textThis study aims on clarifying a relational structure of society and individual in the philosophy of Kitaro Nishida, especially focusing on his early work titled “Society and Individual” (first published in 1922). In Taisho era, when Japan was under crisis of human survivability challenged by political and economic disturbances after the World War, natural disasters and prevailing poverty in transitional democratization and capitalisation, ‘society' became one of the focal topic among scholars. On the other hand, the past criticisms stirred against Nishida before and after the World War II have found a main problem of Nishida philosophy in a scarcity of "process" description between individuality and absolute nothingness in his absolute dialectical logic. This exploration investigates the notion of ‘society' in the early Nishida's philosophy, which depicts society and individual as a fractal structure, accepting plurality of subjects and constant confliction among meanings and wills. Through demarcating the sense of ‘society,' the author attempts to spot a light on the misunderstandings in the past criticisms against Nishida and on his unique perspective of society and individual in the modernizing period of Japan
Society and Individual in the Early Nishida Philosophy
No full textThis study aims on clarifying a relational structure of society and individual in the philosophy of Kitaro Nishida, especially focusing on his early work titled “Society and Individual” (first published in 1922). In Taisho era, when Japan was under crisis of human survivability challenged by political and economic disturbances after the World War, natural disasters and prevailing poverty in transitional democratization and capitalisation, ‘society' became one of the focal topic among scholars. On the other hand, the past criticisms stirred against Nishida before and after the World War II have found a main problem of Nishida philosophy in a scarcity of "process" description between individuality and absolute nothingness in his absolute dialectical logic. This exploration investigates the notion of ‘society' in the early Nishida's philosophy, which depicts society and individual as a fractal structure, accepting plurality of subjects and constant confliction among meanings and wills. Through demarcating the sense of ‘society,' the author attempts to spot a light on the misunderstandings in the past criticisms against Nishida and on his unique perspective of society and individual in the modernizing period of Japan.</div
TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes
No full textWhen a cardiac muscle is held in a stretched position, its [Ca2+] transient increases slowly over several minutes in a process known as stress-induced slow increase in intracellular Ca2+ concentration ([Ca2+]i) (SSC). Transient receptor potential canonical (TRPC) 3 forms a non-selective cation channel regulated by the angiotensin II type 1 receptor (AT1R). In this study, we investigated the role of TRPC3 in the SSC. Isolated mouse ventricular myocytes were electrically stimulated and subjected to sustained stretch. An AT1R blocker, a phospholipase C inhibitor, and a TRPC3 inhibitor suppressed the SSC. These inhibitors also abolished the observed SSC-like slow increase in [Ca2+]i induced by angiotensin II, instead of stretch. Furthermore, the SSC was not observed in TRPC3 knockout mice. Simulation and immunohistochemical studies suggest that sarcolemmal TRPC3 is responsible for the SSC. These results indicate that sarcolemmal TRPC3, regulated by AT1R, causes the SSC.Fil: Yamaguchi, Yohei. Okayama University; JapónFil: Iribe, Gentaro. Okayama University; JapónFil: Kaneko, Toshiyuki. Asahikawa Medical University; JapónFil: Takahashi, Ken. Okayama University; JapónFil: Numaga-Tomita, Takuro. National Institutes of Natural Sciences; JapónFil: Nishida, Motohiro. National Institutes of Natural Sciences; JapónFil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Research Triangle Park; Estados UnidosFil: Naruse, Keiji. Okayama University; Japó
Decreased sensitivity to anticancer drugs in colorectal cancer and side effects of cancer chemotherapy
No full text近畿大学Kindai University博士（薬学）主査：小竹武 教授 学内授与番号：薬第174号
Yusuke Morii, Masanobu Tsubaki, Tomoya Takeda, Rie Otubo, Shiori Seki, Yuta Yamatomo, Motohiro Imano, Takao Satou, Kazunori Shimomura, Shozo Nishida "Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation" European Journal of Pharmacology, Volume898, 5 May 2021, 173957
https://doi.org/10.1016/j.ejphar.2021.173957 掲載
Y Morii, S Fujimoto, R Nakahara, K Okawa, H Senaha, K Fujiwara, M Tsubaki, S Matzno, M Takegami, K Shimomura, S Nishida "Effect of proton pump inhibitors on the development of hypomagnesemia induced by panitumumab" Die Pharmazie-An International Journal of Pharmaceutical Sciences, Volume77, Number2, February 2022, pp.81-84(4)
https://www.ingentaconnect.com/contentone/govi/pharmaz/2022/00000077/00000002/art00007 掲載application/pdfdoctoral thesi
Cross-correlation functions used in "Sedimentary structure from multi-mode ambient noise tomography with dense OBS network at the Japan Trench"
No full textThe cross-correlation functions are used in "Sedimentary structure from multi-mode ambient noise tomography with dense OBS network at the Japan Trench", by Lina Yamaya, Kimihiro Mochizuki, Takeshi Akuhara, and Kiwamu Nishida.
For more information, please contact the first author
大腸がんにおける抗がん剤感受性低下の機序解明とがん化学療法における副作用発現に関する臨床的研究
No full text主査：小竹武 教授 学内授与番号：薬第174号
Yusuke Morii, Masanobu Tsubaki, Tomoya Takeda, Rie Otubo, Shiori Seki, Yuta Yamatomo, Motohiro Imano, Takao Satou, Kazunori Shimomura, Shozo Nishida "Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation" European Journal of Pharmacology, Volume898, 5 May 2021, 173957
https://doi.org/10.1016/j.ejphar.2021.173957 掲載
Y Morii, S Fujimoto, R Nakahara, K Okawa, H Senaha, K Fujiwara, M Tsubaki, S Matzno, M Takegami, K Shimomura, S Nishida "Effect of proton pump inhibitors on the development of hypomagnesemia induced by panitumumab" Die Pharmazie-An International Journal of Pharmaceutical Sciences, Volume77, Number2, February 2022, pp.81-84(4)
https://www.ingentaconnect.com/contentone/govi/pharmaz/2022/00000077/00000002/art00007 掲載application/pd
- …
