149 research outputs found
From Islamic Fundamentalism to a New Life in the West: Ali Eteraz and the Muslim Comedy Memoir
No full textThis chapter analyses the Muslim memoir as a hybrid text that both authenticates and satirises the subjectivity of the narrator. Given the social capital of the memoir form, I argue that its trustworthiness is inverted by the author Ali Eteraz to question the premise of social trust. The memoir delineates social trust through the expression of piety and Muslim modernity articulated by the narrator in his different avatars. Eteraz’s satirical representations of himself invite the reader to read against the grain of the by now familiar Muslim fundamentalist-turned-Sufi story. He reverses the contexts of Islamist violence with the performativity of humour and it is in that humour that we can see traces of a multicultural coexistence and a rebuilding of social trust
Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development
No full textAniruddha Agarwal, William R Rhoades, Mostafa Hanout, Mohamed Kamel Soliman, Salman Sarwar, Mohammad Ali Sadiq, Yasir Jamal Sepah, Diana V Do, Quan Dong Nguyen Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA Abstract: Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described. Keywords: AMD, neovascular AMD, choroidal neovascular membrane, pharmacogenomics, VEGF, low-vision rehabilitation, gene therap
Studies on the method of orthogonal collocation 11: an efficient numerical method for the solution of the transient heat conduction problem
No full textAn efficient numerical method for the solution of the transient heat conduction problem is developed using the orthogonal collocation method. The method is based on dividing the domain of temperature change into two zones; a zone for which the temperature profile is steep and a zone with no temperature change. As time increases the inactive zone disappears and a modifIed collocation method is used
Studies on the Method of Orthogonal Collocation III. The Use of Jacobi Orthogonal Polynomials for the Solution of Boundary Value Problems
No full textPrevious work identified the kind of Jocobi polynomials suitable to solve boundary value problems of the diffusion type in a slab, cylinder or sphere. In this paper we identify the general form of boundary value problems for which Jacobi orthogonal polynomials are optimal when they are used within the framework of the method of orthogonal collocation
Studies on the method of orthogonal collocation ll:the use of jacobi orthogonal polynomials for the solution of boundary value problems
No full textPrevious work identified the kind of Jocobi polynomials suitable to solve boundary value problems of the diffusion type in a slab, cylinder or sphere. In this paper we identify the general form of boundary value problems for which Jacobi orthogonal polynomials are optimal when they are used within the framework ofthe method of orthogonal collocation
Abstract 175: Combination of plasmonic photothermal therapy with surgery applied to naturally occurring mammary tumors in canines and felines: clinical outcomes and molecular studies
No full textAbstract
Plasmonic Photothermal Therapy (PPTT) is a cancer therapy where gold nanorods (AuNRs) are injected at the tumor site and near-infrared light (safe to bio-system) is applied to generate localized heat causing cancer cell death. PPTT is a potentially good alternative to replace traditional surgery for localized tumors. However, for large tumors (volume ≥10 cm3), PPTT could be ineffective due to an uneven distribution of injected AuNRs causing possible inhomogeneity of heat. Surgery is frequently recommended in those cases. However, it carries a high risk of cancer recurrence. For effective treatment of large tumors, we combined both PPTT and surgical resection and applied it to naturally occurring tumors in mammary glands of dogs and cats, which could realistically represent their human equivalents at the molecular level. For the experimental design, we divided the animals into three different groups. 20 cases (7 cats and 13 dogs) were all diagnosed with adenocarcinoma; the animals were monitored for 1-2 years after treatments. Group (I): three cases were solely treated by mastectomy (control group); all of them died within a few weeks. Group (II): five cases were treated with mastectomy first. Then, each tumor wound was divided into two halves, and only one half was exposed to PPTT. After treatment, two cases in this group rendered complete remission. In the other three cases, the half wound that was not exposed to PPTT had tumor recurrence causing animal death within one year. Group (III): 12 cases were treated with surgery followed by PPTT treatment. This regime showed complete remission without any recurrence for eight cases. However, four cases died 4-12 months after therapy for reasons such as pneumonia (no tumor found, based on X ray). Histopathology results showed a decrease of cancer grades before (variant grades from 1-4) and after two weeks of treatment via PPTT and surgery (grade 0). Blood tests (conducted 1 year after therapy) showed no obvious change in liver and kidney functions in groups II and III. In addition, X-ray diffraction showed no metastasis 1- 2 years after treatment. We have performed quantitative, real time-PCR analysis two weeks before and after treatment to study the expression levels of several important genes. The genes that are responsible for repairing cancer cells such as BRCA1, BRCA2, and CD163-IL-10 were significantly diminished two weeks after treatment (group III). Furthermore, tumor microenvironment cells such as tumor-associated macrophages (TAMs) were greatly altered after treatment. TAM 1, which retards tumor growth, augmented, and TAM 2, which promotes tumorigenesis, was diminished, which explains the animals’ increased survival rate. In conclusion, our study demonstrates the feasibility of applying PPTT after surgery for large tumors in dogs and cats.
Citation Format: Moustafa R. Ali, Haithem A. Farghali, Hala R. Ali, Ahmed H. Osman, Yousef A. Soliman, Yue Wu, Ibrahim M. Ibrahim, Salah A. Selim, Dong M. Shin, Mostafa A. El-Sayed. Combination of plasmonic photothermal therapy with surgery applied to naturally occurring mammary tumors in canines and felines: clinical outcomes and molecular studies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 175. doi:10.1158/1538-7445.AM2017-175</jats:p
Complicated corneal ulceration in cats: diagnosis and treatment outcomes of 80 cases (2014-2018)
No full textΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΛΗΨΗThe study describes the most common clinical and endoscopic findings associated with complicated corneal ulcers in cats and evaluates the short-term outcomes after surgical interventions. Eighty client-owned cats of different breeds with corneal ulcers were included. Cats were clinically evaluated to initially determine corneal abnormalities. Endoscopic examination of the corneas was performed to determine anterior and posterior segments’ abnormalities. Non-healing superficial ulcer was treated by superficial keratectomy and deep stromal ulcers were treated using conjunctival flaps. Corneal sequestrum were treated by partial keratectomies and conjunctival flaps. Anterior synechiae were treated via peripheral iridectomy and separation of the adhesion between the iris and the inner cornea. Symblepharon were treated by removal of the adhered conjunctival membrane from the cornea. Unresponsive endophthalmitis was treated surgically by exenteration. Outcomes after surgical managements of selected corneal abnormalities were assessed clinically and endoscopically. Non-healing superficial ulcer, deep stromal ulcer with descemetocele, endophthalmitis, symblepharon, corneal sequestration and anterior synechiae with secondary glaucoma and corneal scarring were the recorded complications of corneal ulcer. FHV-1 was a common etiologic factor of corneal ulceration. Persistent corneal scars of varying shape and size developed in cats with deep stromal ulcer, anterior synechiae, and corneal sequestration. Domestic shorthaired and Persian cats were the most predisposed breeds to FHV-1 infection and subsequent corneal ulceration. Management of patients with corneal ulcer would prevent serious complications. No age or sex predisposition to complicated corneal ulceration in cats was noticed
OCCUPATIONAL BURNOUT AMONG NURSES WORKING IN MATERNAL AND CHILD HEALTH CENTERS IN EL BEHEIRA GOVERNORATE
No full textAbstract: Nurses who are working in maternal and child health care setting suffer from excessive load that makes them more liable for occupational burnout because their work involves many preventive and curative health services that are provided to both women and under-five children. The study aimed to: assess the level of occupational burnout among nurses working in Maternal and Child Health centers (MCH) in El Beheira Governorate. Design: a descriptive study was utilized to meet the aim of this study. Setting: The study was conducted in 9 MCH centers within 5 directorates out of 16 directorates present in El Beheira Governorate including Damanhour, Kafer El dawar, Abo Elmatamer, Etay Elbarod and Shobarqet directorates. These directorates have the greatest number of nurses within MCH centers. Subjects: composed of 300 nursing staff who are working at previously mentioned setting. Tools: two tools were used for data collection; Nurses’ characteristics self –administrated sheet and The Maslach Burnout Inventory (MBI). Results: around two third of the studied nurses had high level of emotional exhaustion, and the majority of them had high level of high depersonalization and personal accomplishment. Moreover, there was a statistically significant negative correlation between emotional exhaustion and personal accomplishment domain and positive correlation between emotional exhaustion and depersonalization. On the other hand, there was no statistically significant correlation between personal accomplishment and depersonalization. Conclusion: based on the results of the present study it can be concluded that, although the current study subjects had high level of emotional exhaustion and depersonalization, they still had high level of personal accomplishment. Moreover, emotional exhaustion was negatively correlated with personal accomplishment and positively correlated with depersonalization. On the other hand, there was no statistically significant correlation between personal accomplishment and depersonalization.
Recommendation: frequent workshops about effective coping strategies to be used during time of stress need to be implemented for nurses to protect against occurrence of burnout.
Keywords: nursing staff, occupational burnout, maternal and child health center.
Title: OCCUPATIONAL BURNOUT AMONG NURSES WORKING IN MATERNAL AND CHILD HEALTH CENTERS IN EL BEHEIRA GOVERNORATE
Author: Mona Ali. S, Mariam Soliman H., Amal Awad M., Emad Fayek R.
International Journal of Novel Research in Healthcare and Nursing
ISSN 2394-7330
Vol. 9, Issue 2, May 2022 - August 2022
Page No: 167-186
Novelty Journals
Website: www.noveltyjournals.com
Published Date: 02-July-2022
DOI: https://doi.org/10.5281/zenodo.6790438
Paper Download Link (Source)
https://www.noveltyjournals.com/upload/paper/OCCUPATIONAL%20BURNOUT-02072022-6.pdfInternational Journal of Novel Research in Healthcare and Nursing, ISSN 2394-7330, Novelty Journals, Website: www.noveltyjournals.co
Effect of lumbar-pelvic control on functionality in children with spastic cerebral palsy
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Novel sulfonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers
No full textA series of sulfonamide benzoquinazolinones 5–18 was synthesized and evaluated for cytotoxic activity against MDA-MB-231 cell line. The compounds showed IC50 ranging from 0.26 to 161.49 µM. The promising compounds were evaluated for their inhibitory profile against epidermal growth factor (EGFR) and HER2 enzymes. Compound 10 showed more potent activity on both EGFR and HER2 than erlotinib (IC50 3.90 and 5.40 µM versus 6.21 and 9.42 µM). The pro-apoptotic activity of 10 was evaluated against caspase-3, Bax, B-cell lymphoma protein 2 (Bcl-2) expression levels, and cell cycle analysis. Compound 10 increased the level of caspase-3 by 10 folds, Bax level by 9 folds, decreased the level of the Bcl-2 by 0.14 and arrested the cell cycle in the G2/M phase. The radio-sensitizing activity of 10 was measured using a single dose of 8 Gy gamma radiation (IC50 decreased from 0.31 to 0.22 µM). Molecular docking was performed on EGFR and HER2 receptors
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