9 research outputs found
On the Use of Supervised Learning Method for Authorship Attribution
Get PDFIn this paper we investigate the use of a supervised learning method for the authorship attribution that is for the identification of the author of a text. We suggest a new, simple and efficient method, which is merely based on counting the number of repetitions of each alphabetic letter in the text, instead of using the traditional classification properties; such as the contents of the text and style of the author; which falls into four feature categories: lexical, syntactic, structural, and content-specific. Furthermore, we apply a spherical classification method. We apply the proposed technique to the work of two Italian writers, Dante Alighieri and Brunetto Latini. With almost high reliability, the spherical classifier proved its ability to discriminate between the selected authors. Finally the results are compared with those obtained by means of a standard Support Vector Machine classifier
Influence of nanoparticles addition on the fatigue failure behavior of metal matrix composites : Comprehensive review
Get PDFAbstractLight-weight, high-strength metal matrix composites (MMCs) have been gaining prominence in various industrial applications in which the materials are exposed to static and dynamic loading conditions. Unfortunately, micron-sized MMCs frequently encounter challenges such as particle breakage and debonding at the reinforcement-matrix interface, resulting in premature failure due to the decline in their mechanical properties, making them impractical to be utilized in some crucial applications. On the other hand, metal matrix nanocomposites (MMNCs) have been proven to improve strength, ductility, and fracture toughness characteristics, which are greatly beneficial in various industrial applications such as automotive, aerospace structures, and biomaterials. This review provides a comprehensive insight into the effect of nanoparticle addition on the fatigue performance of metals and alloys. Firstly, special attention has been given to the factors influencing the fatigue life of MMNCs. Secondly, the effect of nanoparticle incorporation on the fatigue performance of common metal matrixes, including aluminum, magnesium, titanium, and steel alloys, is reviewed in detail. Finally, a summary of this review and the future aspects related to the behavior of metals with nanoparticles at cyclic loading is provided.Abstract
Light-weight, high-strength metal matrix composites (MMCs) have been gaining prominence in various industrial applications in which the materials are exposed to static and dynamic loading conditions. Unfortunately, micron-sized MMCs frequently encounter challenges such as particle breakage and debonding at the reinforcement-matrix interface, resulting in premature failure due to the decline in their mechanical properties, making them impractical to be utilized in some crucial applications. On the other hand, metal matrix nanocomposites (MMNCs) have been proven to improve strength, ductility, and fracture toughness characteristics, which are greatly beneficial in various industrial applications such as automotive, aerospace structures, and biomaterials. This review provides a comprehensive insight into the effect of nanoparticle addition on the fatigue performance of metals and alloys. Firstly, special attention has been given to the factors influencing the fatigue life of MMNCs. Secondly, the effect of nanoparticle incorporation on the fatigue performance of common metal matrixes, including aluminum, magnesium, titanium, and steel alloys, is reviewed in detail. Finally, a summary of this review and the future aspects related to the behavior of metals with nanoparticles at cyclic loading is provided
Surface nanocratering by localized plasma expansion induced by slow highly charged ions
No full textIon beam technology provides a powerful means for surface modification and nanostructuring of materials. In this work, slow highly charged xenon ions were used to fabricate well-defined nanopits in thin polymethyl methacrylate (PMMA) films. The pit surface density scales linearly with the applied ion fluence, demonstrating that each structure originates from a single ion impact. The formation of these nanopits is interpreted within a plasma expansion framework, in which the potential energy of an individual highly charged ion creates a transient, localized plasma within a nanometric surface region. The subsequent plasma expansion ejects material and produces a shallow surface depression. Numerical solutions of the hydrodynamic equations for the plasma components yield expansion parameters that agree with the experimentally observed pit dimensions and aspect ratios, confirming the plausibility of the proposed mechanism
Phenolic metabolites, biological activities, and isolated compounds of Terminalia muelleri extract
No full text© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.[Context]: Terminalia muelleri Benth. (Combretaceae), is rich with phenolics that have antioxidant and cytotoxic activities. No screening studies were published before on T. muelleri.[Objective]: The study focused on isolation and identification of secondary metabolites from aqueous methanol leaf extract of T. muelleri and evaluation of its biological activities.[Materials and methods]: The n-butanol extract was chromatographed on polyamide 6, and eluted with H2O/MeOH mixtures of decreasing polarity, then separated by different chromatographic tools that yielded 10 phenolic compounds. The antioxidant activity of the extract was evaluated by investigating its total phenolic and flavonoid content and DPPH scavenging effectiveness. The extract and the two acylated flavones were evaluated for their anticancer activity towards MCF-7 and PC3 cancer cell lines. Molecular docking study of the acylated flavones was performed against topoisomerase enzyme.[Results and discussion]: Two acylated flavonoids, apigenin-8-C-(2″-O-galloyl) glucoside 1 and luteolin-8-C-(2″-O-galloyl) glucoside 2, were isolated and identified for the second time in nature, with eight tannins (3–10), from the leaves of T. muelleri. The extract and compound 10 showed the most significant antioxidant activity (IC50 = 3.55 and 6.34 μg/mL), respectively. The total extract and compound 2 demonstrated cytotoxic effect against MCF-7 with IC50 = 29.7 and 45.2 μg/mL respectively, while compound 1 showed cytotoxic effect against PC3 (IC50 = 40.8 μg/mL). The docking study of compounds 1 and 2 confirmed unique binding mode in the active site of human DNA topoisomerase enzyme.[Conclusions]: Terminalia muelleri is a promising medicinal plant as it possesses high antioxidant activity and moderate cytotoxic activity against MCF-7.Peer Reviewe
Development and evaluation of a societal core robotic surgery accreditation curriculum for the UK.
No full textOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Standardised proficiency-based progression is the cornerstone of safe robotic skills acquisition, however, is currently lacking within surgical training curricula. Expert consensuses have defined a modular pathway to accredit surgeons. This study aimed to address the lack of a formal, pre-clinical core robotic skills, proficiency-based accreditation curriculum in the UK. Novice robotic participants underwent a four-day pre-clinical core robotic skills curriculum incorporating multimodal assessment. Modifiable-Global Evaluative Assessment of Robotic Skills (M-GEARS), VR-automated performance metrics (APMs) and Objective Clinical Human Reliability Analysis (OCHRA) error methodology assessed performance at the beginning and end of training. Messick's validity concept and a curriculum evaluation model were utilised. Feedback was collated. Proficiency-based progression, benchmarking, tool validity and reliability was assessed through comparative and correlational statistical methods. Forty-seven participants were recruited. Objective assessment of VR and dry models across M-GEARS, APMs and OCHRA demonstrated significant improvements in technical skill (p < 0.001). Concurrent validity between assessment tools demonstrated strong correlation in dry and VR tasks (r = 0.64-0.92, p < 0.001). OCHRA Inter-rater reliability was excellent (r = 0.93, p < 0.001 and 81% matched error events). A benchmark was established with M-GEARS and for the curriculum at 80%. Thirty (63.82%) participants passed. Feedback was 5/5 stars on average, with 100% recommendation. Curriculum evaluation fulfilled all five domains of Messick's validity. Core robotic surgical skills training can be objectively evaluated and benchmarked to provide accreditation in basic robotic skills. A strategy is necessary to enrol standardised curricula into national surgical training at an early stage to ensure patient safety
Mapping breast cancer journal publications in conflict settings in the MENA region:a scoping review
Get PDFBackground: Breast cancer is a major cause of cancer-related morbidity and mortality among women in the the Middle East and North Africa (MENA) region. Conflict and political instability in the region may affect medical research output, including that on breast cancer. This scoping review aims to systematically identify and map breast cancer publications across different stages of the cancer care pathway and across conflict-affected countries within the MENA region. The findings of this work will highlight the impact of conflict on cancer research that could be mitigated with the proper contextualised capacity strengthening intervention. Methods: We followed the PRISMA-Scr methodology. We searched for peer-reviewed publications on topics related to breast cancer in 11 databases: Medline, PubMed, EMBASE, Web of Science, PROQUEST, CINAHL, Global Index Medicus, Arab World Searches Complete, Popline, Scopus and Google Scholar using both controlled vocabulary and keywords. Publication abstracts and full-text versions were screened for duplicates and included in our study based on pre-specified eligibility criteria: focused on breast cancer, related to the specific country of analysis and human or health system studies. We used a structured data extraction form to extract information related to the article, its methodology and the cancer care pathway being studied. Results: A total of 19,215 citations were retrieved from our search. After removing duplicates, a total of 8,622 articles remained. Title and abstract screening retained 1,613 articles. Publications with first author affiliations to Turkey were consistently the highest across all categories of the cancer care pathway. Trends show an increase in articles from Lebanon, Jordan and Palestine after 2015. Early exploratory and epidemiological studies represented the majority of breast cancer research, followed by policy and implementation research and lastly experimental research. Most research conducted followed an observational study design. Important gaps were identified in the research output related to advanced breast cancer and palliative care (Libya, Syria and Yemen), mental health (Libya), and knowledge and education of breast cancer (Libya and Syria). Conclusion: This scoping review has identified key areas in breast cancer research that lack significant research activity in conflict MENA settings. These areas, including but are not limited to palliative care, mental health, and education, can be prioritised and developed through regional collaboration and contextualised capacity strengthening initiatives.</p
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
Get PDFVariability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types. © 2021 The Author(s
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No full textDAILY PALO ALTO TIMES, FRIDAY. NtiVKMBKH
■ifr 'P*
Palo Alto Garage
and Machine Shop
' W Hl«h Mr-e*.
Fhmmo SM Polo Alio,
All kinds ol machine shop work
solicited ->ecoDd-hsnd automobllee
boagbt and solo Floot space IS
•od up p*r month tlaaollo**, Oil*
•Jtd ssachlne sapplli-s of all kind*
for sol*.
I CEO. BL BENTLEY
4 All old and oew work, to-
t side or otttaM*. _*t1—1*>
♦ ■*•"***
Keatdeara 196 Iloesr ***-
X an*. 1'h ons MIX.
♦ AlabastlB* tor sal., W*I
♦ kalsomln* Is as*, sll cetera
Elite Market
ii. Fl_rur
Phonr 7
Selected Meats Always on hand.
Fish and Poultry
Regular Deliveries to the
Campos snd Menlo
Psrk
..«i..»«,
Phone ISO
City Market
V.
B. SANDERS
tukra
_ rr«h and Salt Meal. j.
sf all kind..
Poultry. Etc
Eterrtlaat First .Uss nl »
lf-l.0»i. jj
trier, a- < (.,* rreaetl. fi
3 SOI tinlrenlty Arena* §
PALO ALTO
Nt-Ure.
Polo Alto, fai Nor I. 1MI
.lids will b* rr-relrerl hy th* un-
derolgoed up to aod Including No
v*nb*r 20. 1*01. for quart era suit-
•hle for po*lo-r_e porpoea* to this
auy. It a-tll be airssory to farnUb
appro itmotely 3.000 squsrr f***t of
ftor space, with * frontag* of not
1*** tb*n thlrtr-two feet. The Isssor
*tll be required lo -aaal* th* qusr-
.«rs with flrst-t-lass hardwood ts-
t»res of quarter-a-aed oak. provide
A* th* osn—ary .omltar* aod for-
akh beet, light and water it is es
ttsaated tbst tbe eqolpwent for the
oaVe will coat In the vidntty of IS.
09* A leaar wilt be entered Into
for a term of Ave or tea y«oi- and
the location offered and the rental
demanded will be dnly eonsld*r*d In
making the selection
Blank proposals aad anr loither
iaforowtloa desired amy be -M-r-sr*d
from Ibe postmaster
II il HAt.L.
Assistant Huperlnteadent, rest-
*M_» D*p*Jt*_*«t.
Southern Pacific
Time Table.
(Chang* ta Ua*. XWort ftaoday.
hs|N*s*h*i M. IMS.)
"Oo* of our tartr lawyem hot
•order caa* I* defsod.*" ssid s Una- !
Una ..flUsl "sad be had * bsnt caa* j
When It re u.r tliae. to so*r_ up be«-4e_
[--riuls**** tu take s re-s-r-sa far ten
-ilu-nea. sail dtirtug that Ico it.t--.ii-
t>* .ml trier tw tbe hotel ta get as
In-ptrstt,*! TVhrii he -aitie b*t-i be
walked oot la front of lb* Jury aad
aald: 'Aa regat-s to this .-sse. tbla 1-
the greelesi i-ouutry on wbk-h the su*
*ver * Ik-ti*- We are the graatvet pew
pie We Im* tbe greatest dewtlay.
Why. geotletnen. every time hob of the*
■hip* of nor glorious aavj sella taio
th* potts or tb* world wllb th* sun
and al-rtpea Sylog ererf ablp of Ibat
power ood every ship of *v*ry other
power fires s satut* froia great caa-
bob la ber honor, and. genUenseu of
the Jvy. if yoo llstee to what the
sa-aodrellj i^-f-OBltkNi of tbt* otaa has
lo say you sn- sIkhh to turstveral* In
prlaoB or baag X,y th* urrk mj poor
aafortaaate .Ileal simply —sc*o*e be
on on* oermtdtm ftrad oo** small revolver
shot at a win wbo unfortonaielj died
on thai (usitos --Itstup-sj Kteatng
San Jose High
Enter. Protest
III . I 111■.■-■ I VHiv TIKI- v»> a
iiiin ur rH.HriuvKiiii- iv.
IH II i i.Vslui |; \ | |ii\
m _
S Pato Alto Package Co.
Th* tsjitee aa Crslss**—a
"Tea." -ji i i the ertttor *s b* put tits
t*m I., u-ii Into tb* ink l-.ttl. sml trical
lo paMe on a ("tin-lag "'tb bis p*>..
"y**. tb* greal fa oil ot o*w*p*p*r ron
trlbotors I* i-sreleea-ees
"ladeed." he cmitlnaad a* he drufi
p*d the <-ooy be had t***o writing Int.
th* w**teb_sh*f aad raarked "Killto-
rlal" orrme lh* eonMT *f a pw*sn eotl
tied -An tide 1" .liestti." -<tn.lrll.iii..r-
«re irrrlMt can-team,
"To*- weald b* ■aiprts*-." aaM b*
as he clipped oot a column of fashion
aet** aad Isbeled tbem •'Foroo." *Sm
see tbe sltpebod writing tbat eeeee*
Into tb* edit.-rial sanctum
"MlMpelted. uapoaet-Sted. wrtttaa
ea both side* of th* ahoot, tlleglbi*. Bb
grammatical stuff. ('ootrlbutors are
terribly t-srel««s Tbey are"
Jaat tbeo tb* -Ac* boy came ta wltb
thai dictatorial aad autocratic manner
be ba* and tlssnaadad taor* copy, and
the editor i.anded htm th* tar* letter
be had Just wrttiea lo hla sweetheart
t'.lebe.
A prulwl has been receltad by the
Kugby union rrom tb* _*n Jo**
High -chool relative to Ihe championship of ihe Saata Clara Coaatr
I>**gu* being awarded lo Palo Alto,
■aa Joae claims that th* Palo Alio
High ricboot was to play lb* winner
of th* Ban -oe*--aata Clara same,
whirl- was won by Saa Joa*. and thl*
final game haa never been played
At the nseetlag of the Kugby
union thl* week tbe matter of th*
eham->loo*fatp was discussed, aad a*
It was stated that tbe game had been
canceled Ibe championship was
awarded to Palo Alto. It aow appears that Saa Joae n*v*r author
iaed the cancellation of the gam*,
aad aa tbetr claim I* a fair ooe th*
Rugby union will hold a *pa_lal
meeting lo consider the protest.
Palo Alto has been notified that
the cbsmplonsblp has been held la
sbeysne-e pending the decision of
th* m f-clal meeting aad
alao been notified to attend the
t-*etlag aad abow <_*_e why a game
wtth San Joee- should aot
played
Thla statement Is quoted from today's Call, under the authorship of
Mr. I'amark Aa Palo Alto ha* de-
f*-*ied Son Jose on two occasion* by
■he respective score* of I to r>
a lo o this would indicat* (hat ther*
Is scari-el* any grounds for another
game between tb* two schools, yet
anr action of tbe union will be accepted as final -**
Owes* Car-line'* Psetim*.
Queen la ml tnr wife of Klag O*orge
IV. of Kagf*ad. with whom saw tea* -
o* Ihe worst rt-_dtd* term*, ta df :
•c*ib*d ta Th* Diary of a Lady la
Waiting" wrtttaa by lady Chariot**
Bury. Th* i-ueen sseass to bar* irt*d j
witi-bcref. aa tfa* king lady Chat- '
lotie unit** o* oa* oc*-*-riea: "Aftsr,
dlaa*r ber rora! blgbnea* modr o onto
figure, a* usual, aad gav* H aa agitable addlttoe ef larg* bora*, then tn-4;
thf** plna "Ul of ber gsrtnents sud
-it-rk tbem Ihrougb and through aad
pat ths -guru to roast aad asett at th* I
fire If It wa* not loo inrlsnchol) tn '
have te do with thl*. I could bsv* j
died of langhlBg Sh* tadalgs* I* this '
•museoent whenever tbere are ao'
strangers st lb* tabl*. aad some tblak
ber ror al brsghniss really ba* a *aprf
Stltioas leltef that dtmtmyltip Ibis ef
Sgy of ber hue band will -flag to pas*
tbe desiroeltoa of bt* rnysl |-*r*oo
Wbat a sltl-r piece of spite* T*t It la
ImpmaBiMa nm to laugh wben ob* b***s
II dOOB "
I.AIMKH Of viMiiil.n
TO NUK-T I'l -i.-i-l.l-:
A very iBlerwtlng meeting of th*
MsySeld Woman's Improtetaent
Club look plare laat Wedheaday afternoon at the borne of Mrs. D. M
To-gui- The fact that Mayfl«ld ha*
beea without a Sagpole aiace the re-
cent retnotal of the old oae.
brought before the ladles, aad after
some dtscusatoo It wa* agreed that
the ri** should i-od-navor to par
chase another to lake lU'plae*. A
t-OBSssllXee coaststlag of Meed*as**
n Mayer, A M. Qrasg and U Hlght
was appointed to make Inquiries snd
take ibe aeceaaary step* lo secure
th* aam* and report tbelr success at
the next meeting
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Juat L.ks a Lsir Mar.
An etderlt g*-ut**>-a*n. who would
rstlir-r sltep Isle than **t tbe mo*l st
tractive breakfast. *as leisurely wand-
iBf hi* War "'"snl tfa* stl Ita at wfaad
be was *tv-at«d by • tit—attilr-s wo-
ia*n
*Ofa SklstfT. s lot of tensg-s sre best
tog a hnr.ir pi nit msa tottsath. Can'l
yeo help"-'
-WnereV-
Itlgbi iiMiiiiMi the corner Ob.
pieaar eotae with nter
Tbe Uie s"***.-*- |ie«red through his
gi'i-1 rlniiiri-il gt***** st lb* c-rROplalB'
sat aad asked
"Is fae a trer-r i-ig hardy gurdy ombT"
"Ob. ne. sir! He's a 'rery small
a***."
Tbeo surely, m. good woman, tb*.
caa't iieest any faelp froai ssa."—X*w
fork Pi***
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Th* *aaa who oaajkot talh Hsrsa
time* » day every day (or aU «*•*_*
to crowds of from one to twenty
thousand la th* open air wlll 1a tke
fntare fa* coa*td*r*d lo.llglb-* for
(ft* pr*s4d*a_y —D*l«th H*-r*-Trlh-
11* gsaerally cb*aper to *tay mor-
rxa* thsa K to ta pay alliaay.
i'i Mini -.i tru -i is
t.niM. (IX THR HTAOR
San Jo**, Nov. IS.- William Hal-
fleta. wbo yeeterday wa* dlacbargad
from ruaiody here after being detained several weeks la 1*11 ta Twaaa
aBd In tht* rlt- as a Dunham suspect, has been engaged by a local
theater to S»*he hla *pp*araai-e oa
the siai' neat Suad%v evening. He
wlll t**ll th* stery of his capture aod
deteailap from th* rear of tb* foot-
light* for * week or Iwo her., and
then will go oa the clrtralt for several weeks. e
The Doomsday Book to s H-itm.
taatUeUea It I* a boo* ef the gaa
•ral aorv** of *■*»■_•?-**f toaiaa.as*d
to the rslgn of William I (tfae 'en
aj»is_n, aboat Iflb. oomo say sbout
HSS If wsa Intended t* b* g r*_tB
ler to determine tb* light I* th* t*a-
ore of aatste*. ta dtoewver tbe esteet
nf any man * land, to Si bla bomag*
*Sd to settle (fa* quest toe ef ibe military aid fae was bauad le famish "
Wsei Attmry Tlm*.
flat* -rea ever totr** sad bsir
tbe «w*ta
-Nope.'' reepowded tbe ■aldea
proeapOy "I've woa every brsarfa af
proestoe suit I ever t.r-ught " Cle»e
land
M*. *w*.*w's |**i Urr4mrr.
The laat tacture of Mr Snows
course on Problems of Rsllgton" Id
th* rnltarlan Chun-b will be give*
next Sunday eienlng at 7:30 o'clock.
H* faaa aaaoaoced for his aafaject
"Forglveneea and the Katur* Ute."
In thla lector* h* will ooaclude hi*
' discussion of tfa* subject of *!*. c*r-
j rled oa for the put two tacture*. by
treating tfae prObWni of It* forgir.*
oass H* will sketrb brlefij th* v*-
: rlnus theories of atonessenl. sud
, brio* th* matter to aa and by a
: coa*1 deration of the rjueatlon from
, tb* vlawpolnl of human esp*rt«oce.
; TW subject of immortal it i will fa*
: iah*b nf la ■ t.Hiii-t nun with • --
, vtaw of the re*ulta of th* coara*
After nest Sunday tfa*re wlll h*
| no further evealag service*, unless
S-pertall-r announced, thl* semester
UUmm Oah-h-S -Wfaat did year ale
ter *aj a _en yoa totd bor I waa goteg
to make » speech in Ji* tagro ball to
nlgbtl Win!*-*-- .ildn'f sar aotbln'
Sfaa Juat tougawS tut sb* bad hv*ter
M.s S«*eet Vs.se.
lie I-M jtm ttror oa* atugta* under
r-or wi»1<.w last nightl f hope pour
father dlda'i bear ttf She Yes fa*
did. _tat yet* needn't worry. II*
t-a-agbt It wa* tb* cat*—Stray Storl**
N*w Th** 0**t't Sa**a.
Mary-D* >oo think It woald Is* coa
ealtad fur at i« wi my Mead* taa
1 mad* tfato dr*** myself> ■dftfe-
Not coacetted, my >1*-*r eeperSuoas
(Uvea Money to Cliarrh.
The will of Haary Brace of Santa
Clara ba* beea Sled for probate by
the esacutora. Attorney J A Perrv
of Saa Franc lore, and Rev P A.
Reeat Tfa* eet alt*- the riact ral a*
• ot whir- to sot known Is U> 11* AC
i tided aa .sHows Oae-lhlrd t* Mrs
j Pmd*m-e Brae*, tb* wlf* of tfa* de*
: ceased; r.n»-thlrd to tfae Mstbodtot
;church, and one ibird to It- t-rtd lo
i trust for Ih* son. a«org* W, Brace.
The decedent had larg* aoldla-m
Panu Clsra sad also In Mendocino
rowntv Tfa* petition wlll be heard
la tfa* probata court va November
doing a* _MM*b good as hi* aitaattoa
allow* him *■■ 4*. 1 ..■ -d
lt to aaM tfaat th* dak* will demand a million dollar dot' If a*
marries MIsb Klklas Thi* offer* a
a«w eaplaoatloo of tfa* maa* tag of
the term foreign eettlemeat worker Phlla-elpfals N'orth Aa_«rloaa.
GROCERS
. The Store that Quotes Prices all the time. The other
fellow lays: _»
"Why sst ttss talkiag Prices,
sai IslK quality ."
Quality is always first with us, but most people want
Both Price and Quality. We have them.
And we are doing More Business than we have ever
done before, so Quality must be in our goods.
WHY HOT TIT -ST
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Biallelic MED27 variants lead to variable ponto-cerebello-lental degeneration with movement disorders
Get PDFMED27 is a subunit of the Mediator multiprotein complex, which is involved in transcriptional regulation. Biallelic MED27 variants have recently been suggested to be responsible for an autosomal recessive neurodevelopmental disorder with spasticity, cataracts, and cerebellar hypoplasia. We further delineate the clinical phenotype of MED27-related disease by characterizing the clinical and radiological features of 57 affected individuals from 30 unrelated families with biallelic MED27 variants. Utilizing exome sequencing and extensive international genetic data sharing, 39 unpublished affected individuals from 18 independent families with biallelic missense variants in MED27 have been identified (29 females, mean age at last follow-up 17±12.4 years, range 0.1-45). Follow-up and hitherto unreported clinical features were obtained from the published 12 families. Brain MRI scans from 34 cases were reviewed. MED27-related disease manifests as a broad phenotypic continuum ranging from developmental and epileptic-dyskinestic encephalopathy to variable neurodevelopmental disorder with movement abnormalities. It is characterised by mild to profound global developmental delay/intellectual disability (100%), bilateral cataracts (89%), infantile hypotonia (74%), microcephaly (62%), gait ataxia (63%), dystonia (61%), variably combined with epilepsy (50%), limb spasticity (51%), facial dysmorphism (38%), and death before reaching adulthood (16%). Brain MRI revealed cerebellar atrophy (100%), white matter volume loss (76.4%), pontine hypoplasia (47.2%), and basal ganglia atrophy with signal alterations (44.4%). Previously unreported 39 affected individuals had seven homozygous pathogenic missense MED27 variants, five of which were recurrent. An emerging genotype-phenotype correlation was observed. This study provides a comprehensive clinical-radiological description of MED27-related disease, establishes genotype-phenotype and clinical-radiological correlations, and suggests a differential diagnosis with syndromes of cerebello-lental neurodegeneration and other subtypes of "neuro-MEDopathies".</p
