4 research outputs found
Intervenção para cuidados de pacientes hipertensos no Centro de Saúde Bom Jesus em Belo Horizonte/MG
No full textIntroduction: This is a work of the Health Center Bom Jesus in Belo Horizonte / MG,
where the author works as a physician, focusing on an important risk factor for cardivascular disease, hypertension. Problem: It was found that there were 453 hypetensive
registered among the population served, which corresponds to approximately 26% of
the population over 40 years registered. Rationale: The high demand for chronic disease care as high blood pressure and the lack of a register of these patients to better
monitoring. Overall objective: To improve the care of patients with hypertension in the
Health Center Bom Jesus. Methodology: Initially, there was a theoretical foundation
carried out by means of a literature survey based on specialization course modules in
Primary Care in Family Health and Virtual Library registers. The design of the operations started with the implementation of a register of patients and parallel, should promote community awareness about the disease. There will be a weekly schedule for the
group of professionals in the health center can gather and analyze and discuss the
events. The evaluation of the intervention plan will occur by analyzing the records of
hypertensive patients and in professional’ self-report obtained at the end of the project.
Expected results: To reduce the number of uncontrolled hypertensive patients; the
incidence of complications of hypertension, and create a register of hypertensive patients.Introdução: esse é um trabalho desenvolvido no Centro de Saúde Bom Jesus, em
Belo Horizonte/MG, onde a autora trabalha como médica, com enfoque em um
importante fator de risco para doenças cardiovasculares, a hipertensão arterial
sistêmica. Situação problema: foi constatado que haviam 453 hipertensos
cadastrados dentre a população atendida, o que corresponde a aproximadamente 26%
da população com mais de 40 anos cadastrada. Justificativa: a alta demanda por
atendimentos de doenças crônicas como hipertensão arterial e a falta de um cadastro
desses pacientes para melhor acompanhamento. Objetivo geral: aprimorar o
atendimento dos pacientes com hipertensão arterial sistêmica no Centro de Saúde Bom
Jesus. Metodologia: Inicialmente realizou-se uma fundamentação teórica por meio de
um levantamento de literatura baseado nos módulos do Curso de Especialização em
Atenção Básica em Saúde da Família e em trabalhos de Biblioteca Virtual. O desenho
das operações deve começar com a implementação de um cadastro dos pacientes e
paralelamente deve-se promover a conscientização da comunidade acerca da doença.
Haverá um horário semanal para que o grupo de profissionais do Posto de Saúde
possa reunir e analisar e discutir os acontecimentos. A avaliação do plano de
intervenção ocorrerá por meio da análise dos cadastros dos pacientes hipertensos e de
discussões baseadas na impressão que cada profissional obteve ao final do projeto.
Resultados esperados: reduzir o número de pacientes hipertensos não controlados;
reduzir o número de complicações da hipertensão arterial; criar um cadastro dos
pacientes hipertensos
Atypical hepatitis B virus serology profile—hepatitis B surface antigen-positive/hepatitis B core antibody-negative—in hepatitis B virus/HIV coinfected individuals in Botswana
No full textDATA AVAILABILITY : The data presented in this study are available upon request from the corresponding author. The data are not publicly available as the sequences are currently being analyzed for other objectives of the bigger project.BACKGROUND : Hepatitis B core antibodies (anti-HBc) are a marker of hepatitis B virus (HBV) exposure; hence, a normal HBV serology profile is characterized by HBV surface antigen (HBsAg) and anti-HBc positivity. However, atypical HBV serologies occur, and we aimed to determine the prevalence of an atypical profile (HBsAg+/anti-HBc-) in a cohort of people with HIV-1 (PWH) in Botswana. METHODS : Plasma samples from an HIV-1 cohort in Botswana (2013–2018) were used. The samples were screened for HBsAg and anti-HBc. Next-generation sequencing was performed using the GridION platform. The Wilcoxon rank-sum test and Chi-squared tests were used for the comparison of continuous and categorical variables, respectively. RESULTS : HBsAg+/anti-HBc- prevalence was 13.7% (95% CI 10.1–18.4) (36/263). HBsAg+/anti-HBc- participants were significantly younger (p < 0.001), female (p = 0.02) and ART-naïve (p = 0.04) and had a detectable HIV viral load (p = 0.02). There was no statistically significant difference in the number of mutations observed in participants with HBsAg+/anti-HBc- vs. those with HBsAg+/anti-HBc+ serology. CONCLUSIONS : We report a high HBsAg+/anti-HBc- atypical serology profile prevalence among PWH in Botswana. We caution against HBV-testing algorithms that consider only anti-HBc+ samples for HBsAg testing, as they are likely to underestimate HBV prevalence. Studies to elucidate the mechanisms and implications of this profile are warranted.Wellcome Trust and the National Institutes of Health (NIH) Common Fund.https://www.mdpi.com/journal/virusesSchool of Public Management and Administration (SPMA
Molecular characterization of hepatitis B virus in people living with HIV in rural and peri-urban communities in Botswana
No full textThis article belongs to the Special Issue titled "Pathogenesis, Diagnosis, and Therapeutics of Infectious Diseases (2nd Edition))".DATA AVAILABITY STATEMENT: The data generated in this study are available upon request from the corresponding author. The sequences are not publicly available, as they are currently being analyzed for other objectives.BACKGROUND : Hepatitis B virus (HBV) sequencing data are important for monitoring HBV evolution. We aimed to molecularly characterize HBV sequences from participants with HBV surface antigen-positive (HBsAg+) serology and occult hepatitis B infection (OBI+). METHODS : We utilized archived plasma samples from people living with human immunodeficiency virus (PLWH) in Botswana. HBV DNA was sequenced, genotyped and analyzed for mutations. We compared mutations from study sequences to those from previously generated HBV sequences in Botswana. The impact of OBI-associated mutations on protein function was assessed using the Protein Variation Effect Analyzer. RESULTS : Sequencing success was higher in HBsAg+ than in OBI+ samples [86/128 (67.2%) vs. 21/71 (29.2%)]. Overall, 93.5% (100/107) of sequences were genotype A1, 2.8% (3/107) were D3 and 3.7% (4/107) were E. We identified 13 escape mutations in 18/90 (20%) sequences with HBsAg coverage, with K122R having the highest frequency. The mutational profile of current sequences differed from previous Botswana HBV sequences, suggesting possible mutational changes over time. Mutations deemed to have an impact on protein function were tpQ6H, surfaceV194A and preCW28L. CONCLUSIONS : We characterized HBV sequences from PLWH in Botswana. Escape mutations were prevalent and were not associated with OBI. Longitudinal HBV studies are needed to investigate HBV natural evolution.The Wellcome Trust; the Fogarty International Center at the US National Institutes of Health; Institutes of Health (NIH) Common Fund and the United States President’s Emergency Plan for AIDS Relief (PEPFAR).https://www.mdpi.com/journal/biomedicinesSchool of Health Systems and Public Health (SHSPH)SDG-03:Good heatlh and well-bein
Climate Haikus from the Global Classroom: A Cross-Cultural Collaboration Between Students from the University of Pretoria in South Africa and Le Mans Université in France
No full textClimate Haikus from the Global Classroom is the result of a remarkable cross-cultural collaboration between students from the University of Pretoria in South Africa and Le Mans Université in France. Through haiku poetry, the students were able to express their fears, hopes and struggles around dealing with climate change in their specific situations while learning from each others’ experiences and reflecting on their own to broaden their horizons and expand their view on how to tackle climate change.This book contains poems from a wide range of students and lecturers alike, from a diverse range of backgrounds in a number of languages including English, French, Japanese, isiZulu, Afrikaans, Italian, IsiXhosa, Korean, Spanish, Southern Sotho and Arabic, reflecting the ways in which climate change affects the lives of people all across the globe.
Contributors
Benaoudi, OuiamBiévelot, ClaraBrownlie, SiobhanChatGPTDuval, MarieGleeson, WilliamGuerrouaz, KhouloudJervais, MathildeKeetse, KhanyisileKonlani, DjayomeKuntz, CamilleLegay, MaëlineMalatse, PalesaMendela, LucienMeyer, StéfanMosia, BonoloMpeppo, OkuhleOllivier Pallud, ColineOuattara, SaraPicault, AmandinePinot, MaévaPillay, NehaSephoko, UnathiTessereau, EmelineZine Eddine, Lili
