222 research outputs found
Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid
No full textElisavet Moutzouri, Anastazia Kei, Moses S Elisaf, Haralampos J MilionisDepartment of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, GreeceAbstract: Cardiovascular disease (CVD) represents the leading cause of mortality worldwide. Lifestyle modifications, along with low-density lipoprotein cholesterol (LDL-C) reduction, remain the highest priorities in CVD risk management. Among lipid-lowering agents, statins are most effective in LDL-C reduction and have demonstrated incremental benefits in CVD risk reduction. However, in light of the residual CVD risk, even after LDL-C targets are achieved, there is an unmet clinical need for additional measures. Fibrates are well known for their beneficial effects in triglycerides, high-density lipoprotein cholesterol (HDL-C), and LDL-C subspecies modulation. Fenofibrate is the most commonly used fibric acid derivative, exerts beneficial effects in several lipid and nonlipid parameters, and is considered the most suitable fibrate to combine with a statin. However, in clinical practice this combination raises concerns about safety. ABT-335 (fenofibric acid, Trilipix®) is the newest formulation designed to overcome the drawbacks of older fibrates, particularly in terms of pharmacokinetic properties. It has been extensively evaluated both as monotherapy and in combination with atorvastatin, rosuvastatin, and simvastatin in a large number of patients with mixed dyslipidemia for up to 2 years and appears to be a safe and effective option in the management of dyslipidemia.Keywords: atherogenic dyslipidemia, cardiovascular disease prevention, lipid-lowering treatment, fenofibric acid, statin
Editorial [Hot topic: Current Topics on Hypolipidaemic Therapy and Cardiovascular Risk Assessment (Guest Editors: Evangelos C. Rizos and Moses S. Elisaf)]
No full textHistoires dans le brouillard : la ville de Ioannina, sources historiques et littéraires (XIXe-XXe siècles) : journée d'études (25/11)
No full textJournée d'études organisée par Anne-Laure Brisac (BnF) et Nicolas Pitsos (BULAC, CREE/Inalco) Programme 14h00 : Accueil des participants Allocutions d'ouverture par Clément Froehlicher-Chaix (BnF) et Jean Chrysoulakis (Secrétaire Général du Secrétariat Général des Grecs de l’étranger et de la Diplomatie publique) Présentation de la journée par Anne-Laure Brisac et Nicolas Pitsos 14h30 : Moses Elisaf (maire de la ville de Ioannina, président de la Communauté israélite de Ioann..
Hyponatremia in the elderly: challenges and solutions
No full textTheodosios D Filippatos, Andromachi Makri, Moses S Elisaf, George Liamis Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece Abstract: Decreased serum sodium concentration is a rather frequent electrolyte disorder in the elderly population because of the presence of factors contributing to increased antidiuretic hormone, the frequent prescription of drugs associated with hyponatremia and also because of other mechanisms such as the “tea and toast” syndrome. The aim of this review is to present certain challenges in the evaluation and treatment of hyponatremia in the elderly population and provide practical solutions. Hyponatremia in elderly subjects is mainly caused by drugs (more frequently thiazides and antidepressants), the syndrome of inappropriate antidiuretic hormone secretion (SIAD) or endocrinopathies; however, hyponatremia is multifactorial in a significant proportion of patients. Special attention is needed in the elderly population to exclude endocrinopathies as a cause of hyponatremia before establishing the diagnosis of SIAD, which then requires a stepped diagnostic approach to reveal its underlying cause. The treatment of hyponatremia depends on the type of hyponatremia. Special attention is also needed to correct serum sodium levels at the appropriate rate, especially in chronic hyponatremia, in order to avoid the osmotic demyelination syndrome. In conclusion, both the evaluation and the treatment of hyponatremia pose many challenges in the elderly population. Keywords: sodium, prognosis, hypopituitarism, elderly, pituitar
Native valve endocarditis due to Micrococcus luteus: a case report and review of the literature
No full textAbstract Introduction Micrococcus luteus endocarditis is a rare case of infective endocarditis. A total of 17 cases of infective endocarditis due to M luteus have been reported in the literature to date, all involving prosthetic valves. To the best of our knowledge, we describe the first case of native aortic valve M luteus endocarditis in an immunosuppressed patient in this report. Case report A 74-year-old Greek-Cypriot woman was admitted to our Internal Medicine Clinic due to fever and malaise and the diagnosis of aortic valve M luteus endocarditis was made. She was immunosuppressed due to methotrexate and steroid treatment. Our patient was unsuccessfully treated with vancomycin, gentamicin and rifampicin for four weeks. The aortic valve was replaced and she was discharged in good condition. Conclusions Prosthetic infective endocarditis due to M luteus is rare. To the best of our knowledge, we report the first case in the literature involving a native valve.</p
ΔΙΑΜΕΣΗ ΝΕΦΡΙΤΙΔΑ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΠΡΩΤΟΠΑΘΕΣ ΣΥΝΔΡΟΜΟ SJOGREN: ΚΛΙΝΙΚΗ, ΕΡΓΑΣΤΗΡΙΑΚΗ ΚΑΙ ΟΡΟΛΟΓΙΚΗ ΜΕΛΕΤΗ
No full textRENAL TUBULAR ACIDOSIS (RTA) IS A FREQUENT EXTRAGLANDULAR MANIFESTATION OF SJOGREN'S SYNDROME. HOWEVER NO DISTINCTION, ON THE INCIDENCE OF THIS RENAL TUBULAR DEFECT BETWEEN PRIMARY AND SECONDARY SJOGREN'S SYNDROME HAS BEEN REPORTED. THIS STUDY WAS UNDERTAKEN IN ORDER TO DEFINE THE FREQUENCY OF RTA AND THE POSSIBLE PATHOGENETIC MECHANISMS IN A GROUP OF 21 RANDOMLY SELECTED PRIMARY SJOGREN'S SYNDROME PATIENTS. RTA WAS FOUND IN 7 (33%) PATIENTS. THE INCOMPLETE TYPE OF THE DISORDER WAS THE MOST FREQUENT. HYPOKALEMIA AND NEPHROLITHIASIS WERE THEMAIN CLINICAL-LABORATORY MANIFESTATIONS OF RTA. IT SEEMS THAT THE ETIOLOGY OFRTA IS MULTIFACTORIAL. RENAL EXCRETION OF MONOCLONAL PROTEINS AND THE IMMUNOLOGICALLY INDUCED INTERSTITIAL INFLAMMATION ARE THE MAIN POSSIBLE FACTORS OF THERENAL TUBULAR LESION.ΕΙΝΑΙ ΓΝΩΣΤΟ ΟΤΙ Η ΝΕΦΡΟΣΩΛΗΝΑΡΙΑΚΗ ΟΞΕΩΣΗ (ΝΣΟ) ΤΥΠΟΥ Ι, ΕΙΝΑΙ ΣΥΧΝΟ ΕΥΡΗΜΑ ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ ΜΕ ΣΥΝΔΡΟΜΟ SJOGREN. ΩΣΤΟΣΟ, ΤΑ ΜΕΧΡΙ ΤΩΡΑ ΒΙΒΛΙΟΓΡΑΦΙΚΑ ΔΕΔΟΜΕΝΑ ΔΕΝ ΞΕΧΩΡΙΖΟΥΝ ΤΗ ΣΥΧΝΟΤΗΤΑ ΤΗΣ ΣΩΛΗΝΑΡΙΑΚΗΣ ΑΥΤΗΣ ΔΥΣΛΕΙΤΟΥΡΓΙΑΣ ΑΝΑΜΕΣΑ ΣΤΟ ΠΡΩΤΟΠΑΘΕΣ Η ΔΕΥΤΕΡΟΠΑΘΕΣ ΣΥΝΔΡΟΜΟ SJOGREN. ΜΕ ΣΚΟΠΟ ΤΗΝ ΑΝΕΥΡΕΣΗ ΤΗΣ ΣΥΧΝΟΤΗΤΑΣ ΚΑΙ ΤΟΥΣ ΠΙΘΑΝΟΥΣ ΠΑΘΟΓΕΝΕΤΙΚΟΥΣ ΜΗΧΑΝΙΣΜΟΥΣ, ΜΕΛΕΤΗΣΑΜΕ 21 ΤΥΧΑΙΑ ΕΠΙΛΕΓΜΕΝΟΥΣ ΑΣΘΕΝΕΙΣ, ΠΟΥ ΠΛΗΡΟΥΣΑΝ ΤΑ ΚΡΙΤΗΡΙΑ ΓΙΑ ΤΗ ΔΙΑΓΝΩΣΗ ΤΟΥ ΠΡΩΤΟΠΑΘΟΥΣ ΣΥΝΔΡΟΜΟΥ SJOGREN. ΒΡΗΚΑΜΕ ΟΤΙ ΝΕΦΡΟΣΩΛΗΝΑΡΙΑΚΗ ΟΞΕΩΣΗ ΥΠΗΡΧΕ ΣΤΟΥΣ ΕΠΤΑ ΑΠΟ ΑΥΤΟΥΣ (ΠΟΣΟΣΤΟ 33%) ΚΑΙ ΟΤΙ ΠΙΟ ΣΥΧΝΑ ΠΑΡΟΥΣΙΑΖΕΤΑΙ ΥΠΟ ΤΗΝ ΑΤΕΛΗ ΤΗΣ ΜΟΡΦΗ. ΟΙ ΚΥΡΙΩΤΕΡΕΣ ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΕΣ ΕΚΔΗΛΩΣΕΙΣ ΤΟΥ ΣΥΝΔΡΟΜΟΥ ΤΗΣ ΝΕΦΡΟΣΩΛΗΝΑΡΙΑΚΗΣ ΟΞΕΩΣΗΣ, ΕΙΝΑΙ Η ΥΠΟΚΑΛΙΑΙΜΙΑ ΚΑΙ Η ΝΕΦΡΟΛΙΘΙΑΣΗ. Η ΑΙΤΙΟΛΟΓΙΑ ΤΟΥ ΣΥΝΔΡΟΜΟΥ ΤΗΣ ΝΕΦΡΟΣΩΛΗΝΑΡΙΑΚΗΣ ΟΞΕΩΣΗΣ, ΦΑΙΝΕΤΑΙ ΟΤΙ ΕΙΝΑΙ ΠΟΛΥΠΑΡΑΓΟΝΤΙΚΗ, ΜΕ ΠΙΘΑΝΟΥΣ ΚΥΡΙΟΥΣ ΠΑΡΑΓΟΝΤΕΣ ΤΗ ΒΛΑΒΗ ΤΩΝ ΝΕΦΡΙΚΩΝ ΣΩΛΗΝΑΡΙΩΝ ΑΠΟ ΤΙΣ ΑΠΕΚΚΡΙΝΟΜΕΝΕΣ ΜΟΝΟΚΛΩΝΙΚΕΣ ΠΡΩΤΕΙΝΕΣ ΚΑΙ ΤΗΝ ΜΕΣΩ ΑΝΟΣΟΛΟΓΙΚΟΥ ΜΗΧΑΝΙΣΜΟΥ ΔΙΑΜΕΣΗ ΦΛΕΓΜΟΝΗ
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