1,355,348 research outputs found
Equilibrium transition study for a hybrid MAV
No full textWind tunnel testing was performed on a VTOL aircraft in order to characterize longitudinal flight behavior during an equilibrium transition between vertical and horizontal flight modes. Trim values for airspeed, pitch, motor speed and elevator position were determined. Data was collected by independently varying the trim parameters, and stability and control derivatives were identified as functions of the trim pitch angle. A linear fractional representation model was then proposed, along with several methods to improve longitudinal control of the aircraft
Moschetta e Grullo : due intermezzi per Siroe re di Persia, Napoli, Teatro di San Bartolomeo, 1727
No full textEdizione critica del libretto e della partitura degli intermezzi Moschetta e Grullo, musica di Domenico Sarr
Between uncertainty and vulnerability: The aging of Ukrainian caregivers in Venice|Tra incertezza e vulnerabilità: L’invecchiamento delle caregivers Ucraine a Venezia
No full textThe ageing of migrant populations in Italy is often overlooked by public policies, exposing this group to significant vulnerabilities. This study examines the experiences of elderly Ukrainian caregivers, who face uncertainties that frequently compel them to extend their work activity beyond retirement age. Based on 15 interviews and three months of participant observation in Venice, as part of a broader research project involving 65 interviews across five Italian cities, the analysis highlights how the lack of intersectional and life-course-sensitive public policies exacerbates the precariousness of elderly migrants. The study underscores the urgency of developing targeted interventions to ensure dignified and sustainable ageing conditions
Relevance of interactions between sphingomyelin and cholesterol in biliary and intestinal tract
No full textPhosphatidylcholine and sphingomyelin are the major phospholipids of the hepatocytic canalicular membrane outer leaflet. Sphingomyelin may preferentially reside with cholesterol in liquid-ordered domains. In contrast, phosphatidylcholine is the exclusive phospholipid secreted in rat bile (enriched in hydrophilic species compared to the canalicular membrane), subsequently incorporated into bile salt-cholesterol micelles. We determined the bile lipid composition in 95 vertebrate species (Moschetta era/., J Lipid Res. 2005, 46, 2221-2232). Phospholipid was often virtually absent in bile of cartilaginous fish and reptiles, occurred in low relative amounts (compared to bile salts) in bony fish or birds and in high relative amounts in most mammals. Biles with low relative amounts of phospholipid often contained high proportions of sphingomyelin. Phosphatidylcholine was the predominant phospholipid in biles with high phospholipid contents. We then compared, in CaCo2 cells (without appreciable phospholipase A2 activity), the effects of incorporating sphingomyelin, egg yolk phosphatidylcholine or lyso-phosphatidylcholine in apical bile salt-cholesterol micelles. Egg yolk phosphatidylcholine and (more pronounced) sphingomyelin inhibited cholesterol absorption with decreased ABC-A1 and -G1 expression. Lyso-phosphatidylcholine enhanced cholesterol absorption with increased basolateral HDL-dependent cholesterol efflux and high expression of ABC-A1 and -G1. In conclusion, sphingomyelin plays a pivotal role in protecting hepatocytes against detergent bile salts. Dietary sphingomyelin may inhibit intestinal cholesterol absorption. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA
Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma.
No full textAbstract
Both primary and transformed cells need cholesterol for their growth. Guo and colleagues unraveled the connection between epidermal growth factor receptor mutations in glioblastoma and increased cholesterol influx via sterol regulatory element-binding protein 1 and low-density lipoprotein receptor (LDLR) increase. They propose the activation of the liver X receptor–inducible degrader of LDLR–LDLR axis as a therapeutic approach to reduce intracellular cholesterol, block tumor growth, and induce cell death. Cancer Discovery; 1(5): 381–2. ©2011 AACR.
Commentary on Guo et al., p. 442.</jats:p
Preface: a special issue on nuclear receptors with a special view on the molecular basis of disease.
No full textMetabolic Messengers: fibroblast growth factor 15/19
No full textFibroblast growth factor (FGF) 15 in mice and its human orthologue FGF19 (together denoted FGF15/19) are gut hormones that control homeostasis of bile acids and glucose during the transition from the fed to the fasted state. Apart from its central role in the regulation of bile acid homeostasis, FGF15/19 is now recognized as a transversal metabolic coordinator at the crossroads of the gut, liver, brain and white adipose tissue. Dysregulation of FGF15/19 signalling may contribute to the pathogenesis of several diseases affecting the gut–liver axis and to metabolic diseases. Here, we provide an overview of current knowledge of the physiological roles of the enterokine FGF15/19 and highlight commonalities and differences between the two orthologues. We also discuss the putative therapeutic potential in areas of unmet medical need—such has cholestatic liver diseases and non-alcoholic steatohepatitis, for which FGF19 is being tested in ongoing clinical trials—as well as the possibility of using FGF19 for the treatment of obesity and type II diabetes
Only non-energy benefits from the adoption of energy efficiency measures? A novel framework
No full text© 2018 Elsevier Ltd Industrial energy efficiency has been widely recognized as a major contributor to the reduction of greenhouse gases emissions and improvement of industrial competitiveness. Nevertheless, a broad set of studies have pointed out the existence of barriers limiting the adoption of promising Energy Efficiency Measures (EEMs). Recently, scholars have shown the relevance of the so-called “non-energy benefits” (NEBs) coming from the adoption of EEMs for overcoming those barriers. Still, the existence of such benefits has been pointed out from specific studies and manuals for practitioners, but an overall framework describing them in terms of savings and benefits, as well as technical and management implications, is missing yet. Moreover, a considerable part of the scholars and of the practitioners just focuses on the identification and definition of the positive benefits deriving from these measures after they have been completely adopted, thus neglecting to describe the full set of both positive and negative effects occurring also during the implementation phase. Thus, starting from a literature review of scientific as well as practitioners’ studies, we have proposed a novel framework and characterization of the relevant items to be considered by an industrial decision-maker when deciding whether to adopt an EEM considering both the implementation and service phases. Hence, by taking this perspective, we have tested and validated the framework and the characterization in a two-step process: firstly, considering a set of EEMs well diffused and adopted in industry; secondly, investigating benefits and losses in ad-hoc selected manufacturing companies. Finally, considerations and implications are drawn from the preliminary validation and suggestion for further research are proposed, for both industrial decision-making as well as policy-making purposes
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