323,266 research outputs found
Skepticism and Justification
No full textThis special issue of Synthese, titled "Skepticism and justification", contains a substantial Introduction (by Coliva, Moruzzi and Volpe), and 9 papers on topics researched by Coliva, Pritchard, Wedgwood, Avnur, Volpe, Dodd, Millar, Gerken, Kallestrup
Post-Enquiry and Disagreement. A Socio-Epistemological Model of the Normative Significance of Disagreement Between Scientists and Denialists
No full textIn this paper we investigate whether and to what extent scientists (e.g. inquirers such as epidemiologists or virologists) can have rational and fruitful disagreement with what we call post-enquirers (e.g. conspiratorial anti-vaxxers) on topics of scientific relevance such as the safety and efficacy of vaccines. In order to accomplish this aim, we will rely and expand on the epistemological framework developed in detail in Ferrari & Moruzzi (2021) to study the underlying normative profile of enquiry and post-enquiry. We take it that our analysis provides an effective explanation of why standard argumentative strategies such as fact-checking and debunking cannot work in the context of disagreement between scientists and denialists unless they are coupled with a discussion of the values that are endorsed by the scientific community
Introduction
No full textThe introduction presents the philosophical problem of vagueness and offers brief introductions to the volume's contributions. The presentations of the volume's contributions is divided by thematic areas so that the reader can have a better understanding of the place of each contribution wirh respect the debate on vagueness
Introduction to Agnosticism on Vagueness
No full textThis paper introduces to the agnostic theories of vagueness
Vagueness and Agnosticism
No full textThe paper presents a novel agnostic theory of vagueness based on a margin error principle for knowledge
Effetto delle poliammine sulla regolazione della proteina cinasi C.
No full textEffetto delle poliamine sulla regolazione della proteina cinasi C. Nel tentativo di contribuire al chiarimento del ruolo delle poliamine sui processi di fosforilazione intracellulari, in questa fase dell’attività di ricerca abbiamo preso in esame gli effetti delle poliamine su diversi aspetti della regolazione della proteina cinasi C (PKC), serina/treonina cinasi che si presenta in diverse forme isoenzimatiche, alcune Ca++/diacilglicerolo (DAG)/fosfolipide dipendenti, ed altre con attività indipendente dal Ca++. Dal momento che l’associazione della PKC alle membrane è il prerequisito essenziale per la risposta fisiologica dell’enzima, particolare interesse è stato rivolto allo studio dell’effetto delle poliamine sul processo di associazione della PKC alle membrane. A questo scopo abbiamo utilizzato un sistema sperimentale costituito da PKC parzialmente purificata da cervello di ratto e da liposomi, costituiti da fosfolipidi acidi, soprattutto acido fosfatidico (PA) e fosfatidilserina (PS). La PKC associata all membrane è stata saggiata quantitativamente come recettore degli esteri del forbolo cioè misurando il legame dell’enzima attivato ad un estere del forbolo radioattivo (3H-PDBu) con cui l’enzima interagisce con una stechiometria di 1:1. Esperimenti eseguiti con liposomi di composizione definita hanno permesso di stabilire che nelle condizioni in cui prevale la formazione del complesso caratterizzato da una stechiometria di legame di 3/4 molecole di PL acido/molecola di SPM si ha un’inibizione nella formazione del complesso attivo. In questo caso infatti sembra che la SPM si disponga parallelamente alla superficie del liposoma impedendo l’ulteriore legame dell’enzima. Al contrario, nelle condizioni in cui prevale la formazione del complesso caratterizzato da una molecola di SPM/molecola di PS, la poliamina sembra legarsi perpendicolarmente alla superficie delle vescicole, e mediante i gruppi amminici non coinvolti nell’interazione con i fosfolipidi legare i siti anionici dell’enzima, favorendo l’interazione della PKC con i liposomi
Guest Editors' Preface
No full textThe preface to Discipline filosofiche special issue on "Knowledge and Justification" provides a background to the eight articles collected therein and a brief summary of each
Basic disagreement, basic contextualism and basic relativism
No full textThe paper shows how basic forms of semantic contextualism and of alethic relativism cannot account for an intuitive and straightforward notion of disagreement, which characterizes those disputes of inclination that have been claimed to be better accounted for by those theories
Introduction: Perspectives on Post-Truth
No full textThis opening piece of the collection 'Perspectives on Post-Truth' aims to accomplish three tasks. First, and foremost, it highlights the issue’s distinctive feature, namely its variegated approach to post-truth. The leading idea in assembling it has been to draw on different methodologies, theoretical approaches, and competences, in order to gain a finegrained understanding of the post-truth condition and to develop an effective toolkit to address the most pressing challenges it poses to our societies. The underlying conviction is that a variegated approach is required by the multifaceted nature of the post-truth condition. The curious reader willing to venture through the issue will thus be exposed to different perspectives on post-truth: some pieces address it from a traditional epistemological perspective, others explore post-truth from the perspective of social epistemology, and still others adopt a semiotic perspective. In light of this multiplicity of perspectives, the second task of this piece has been to provide a brief thematic overview of the key issues and perspectives in order to illustrate the overall narrative of the project. The third and final task has been to give a detailed synopsis of each
contribution so that the reader will know precisely what to expect from it
Truth relativism and Evans' challenge
No full textIn this paper I develop a version of Evans’ challenge for MacFarlane’s assessment-sensitive relativism. The argument is meant to show that, contrary to MacFarlane’s intentions, the correctness of an assertion is a relative matter if the area of discourse has an assessment-sensitive semantics. Thus MacFarlane’s truth-relativism is an inherently unstable doctrine for it is unclear how we should behave in order to achieve the goal of an assertion
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