1,399 research outputs found
Dùn Èistean and the 'Morrisonso' of Ness in the the Lordship of Lewis : The historical background, c. 1493 – c.1700
No full textA review and analysis of the documentary evidence for the 'brieves' or the 'Clan Morrison' and what this can tell us about the population in and around this fortified sea stack in the north of the island of Lewis, c. 1493-1700. This was produced to accompany an archaeological report following ecavation at the Dun Eistean site in the north of Lewis. The documentary record provides evidence which challenges notions, past and present, of the area as being 'remote' and isolated. The people in the vicinity of this sea stack are placed firmly in their Atlantic, Scottish and British contexts
Incorporation of Ophiobolin A into Novel Chemoembolization Particles for Cancer Cell Treatment
No full textPurpose To design and synthesize chemoembolization particles for
the delivery of Ophiobolin A (OphA), a promising fungal-derived
chemotherapeutic, directly at the tumour location. To investigate cell
death mechanism of OphA on a Rhabdomyosarcoma cancer (RD)
cell line. Rhabdomyosarcoma is the most common soft tissue sarcoma
in children; with a 5-year survival rate of between 30 and 65%.
Methods Multimodal chemoembolization particles were prepared
by sintering mesoporous silica nanoparticles, prepared by the sol-gel method, onto the surface of polystyrene microspheres, prepared by suspension copolymerisation. The chemoembolization particles were subsequently loaded with OphA. The effects of OphA in vitro were characterised by flow cytometry and nanoparticle tracking analysis (NanoSight).
Results High loading of OphA onto the chemoembolization
particles was achieved. The subsequent release of OphA onto
RD cells in culture showed a 70%reduction in cell viability. OphA
caused RD cells to round up and their membrane to bleb and
caused cell death via apoptosis. OphA caused both an increase in
the number of microvesicles produced and an increase in DNA
content within these microvesicles.
Conclusions The prepared chemoembolization particles showed good efficacy against RD cells in culture
Supplemental video 1 and video 2 to preprint article: Surface acoustic wave integrated microfluidics for repetitive and reversible temporary immobilization of C. elegans
No full textNo audio.The ZIP file contains two supplemental videos to the preprint article: BIORXIV/2022/496864; Surface Acoustic Wave Integrated Microfluidics for Repetitive and Reversible Temporary Immobilization of C. elegans by Nakul Sridhar, Apresio Kefin Fajrial, Rachel L. Doser, Frederic L. Hoerndli, and Xiaoyun Ding
'Do it Yourself' Girl Revolution: LadyFest, Performance and Fanzine Culture
No full textRiot grrrl began as an independent music and political movement in the early 1990s emerging initially in the USA and few years later in the UK. From the beginning riot grrrl embraced a 'do-it-yourself' ethos operating outside the mainstream music business organising independent music festivals, workshop events and encouraging self-published fanzines (fan magazines which were distributed primarily through word of mouth, music gigs, artists and zine book fairs or by post). These zines became recognisable forms of personal expression and made visible a specific DIY approach alongside the development of a coherent style of graphic language in the producer's use of the photocopier, handwritten and graffiti texts, cut-n-paste and ransom note lettering style, collage and the co-option of mainstream media imagery. These production techniques made fanzine publishing accessible and played a central role in the development of a non-hierarchical community.
The main intent of this talk is to explore the idea of 'event as performance' using as a case study the specific activities of riot grrrl and focussing on a series of international events called 'LadyFests' and the graphic language of self-published riot grrrl fanzines. This will be achieved by examining the origins of today's riot grrrl performances (e.g. theatre, spoken word, music events) in 1970s feminist art, as well as locating the activities within the specific context of their counter-cultural predecesors including punk and punk performance
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A cross species metabolomics analysis on the effect of biological stressors such as depression and sleep loss on the host metabolome
No full textIt would be next to impossible to list the many people who have supported and helped me get to where I am today. My trajectory from birth to graduate school has not been linear. I have always had a natural curiosity about the world around me; starting from my time growing up as an illegal immigrant in the city of Los Angeles, to my time served as rifleman in the United State Marine Corps, and my current position as a scientist. The richness of these experiences has had a profound influence on the way I approach life. Through it all, Patricia, my mother, sacrificed everything and made this possible. Cristina, my younger sister, has been a constant reminder that I have an obligation as an older brother to make her proud. Arpa, my love and joy, has walked this crucible called graduate school next to me, and has been a constant source of love and encouragement. To the three most important people in my life, thank you for everything. My success as a scientist can be attributed to the various scientist I can call mentors and friends. Professor Jamil Momand, my undergraduate advisor and research mentor, introduced me to the field of biochemistry and encourage me to pursue my Ph.D.. Thank you for your guidance and support. Professor Pieter C. Dorrestein, my Ph.D mentor, provided me with a once in a life time experience graduate education in mass spectrometry and its application in life sciences. I cannot express how thankful I am for your mentorship, guidance, and support. The environment that you have cultivated in the Dorrestein lab provided me with the tools and opportunities to grow and succeed as a researcher. I will always appreciate everything that you have done for me. I would also like to thank my committee members for their role in my graduate education, thank you Professor Rob Knight, Professor Rachel Dutton, Professor Susan S. Golden, and Professor Jose Pruneda-Paz.Chapter 2, in full, is a reprint of the material as it appears in Journal of The American Society for Mass Spectrometry 2019. da Silva, R. R; Vargas, F; Ernst, M; Nguyen, N. H; Bolleddu, S; del Rosario, K. K; Tsunoda, S. M; Dorrestein, P. C; Jarmusch, A. K.; Springer US, 2018. The dissertation author was a primary investigator and author of this paper. Chapter 3, in full, has been submitted for publication of the material as it may appear in Rapid Communications in Mass Spectrometry, 2019, Vargas, F; Weldon, K. C; Sikora, N; Wang, M; Zhang, Z; Gentry, E. C; Panitchpakdi, M. W; Caraballo, M; Dorrestein, P. C; Jarmusch, A. K.; John Wiley & Sons, 2019. The dissertation author was the primary investigator and author of this paper. Chapter 4, in full, has been submitted for publication of the material as it may appear in Frontiers in Psychiatry, 2019, Vargas, F; Dethloff, F; Emmanuel, E; Quinn, R; Park, D. I; Herzog, D. P, Müller, M. B; Gentry, E. C; Knight, R; Gonzalez, A; Dorrestein, P. C; Turck, C. W.; Frontiers Media, 2019. The dissertation author was the primary investigator and author of this paper. Chapter 5, in full, has been submitted for publication of the material as it may appear in Scientific Reports, 2019, Thompson, R. S; Vargas, F; Dorrestein, P. C; Chichlowski, M; Berg, B. M; Fleshner, M.; Nature Publishing Group, 2019. The dissertation author was a primary investigator and author of this paper. Chapter 6, in full, has been submitted for publication of the material as it may appear in Sleep, 2019, Bowers, S. J; Vargas, F; Gonzalez, A; He, S; Jiang, P; Dorrestein, P. C; Knight, R; Wright, K. P; Lowry, C. A; Fleshner, M; Vitaerna, M. H; Turek, F. W.; Oxford University Press, 2019. The dissertation author was a primary investigator and author of this paper
Open destinies : modern American women and the short story cycle
No full textThis thesis examines the juncture between the short story cycle form and gender politics. It explores how twentieth-century women from the United States have been using the form to represent and question gender identity. The introduction outlines commentaries on the story cycle and considers definitions of the form. It includes case studies of earlier twentieth-century cycles by American women: cycles such as Mary McCarthy's The Company She Keeps that have been passed over by critics of the form.
Chapter One presents Eudora Welty's The Golden Apples as a cycle paradigm, examining conventions such as the form's metafictional dimension and its preoccupation with communal identity. Chapter Two argues that Grace Paley's scattered Faith narratives set a standard for more dispersed versions of the form. Chapter Three considers how Joyce Carol Oates uses the sequential cycle to represent gender identity as a social construct. Chapters Four and Five examine the macrocosmic cycles of Gloria Naylor and Louise Erdrich and consider changes in their form and gender politics. The final 'composite' chapters explore postmodern versions of the form such as Susan Minot's Monkeys. The prose works of Sandra Cisneros stretch across the story cycle continuum, whilst Toni Morrison's Paradise is universally regarded as a novel. Readings of contemporary cycles by Melissa Bank, Elissa Schappell and Emily Carter demonstrate that American women are re-invigorating the form to facilitate the plural identity of the postmodern heroine
"Shuttles in the rocking loom of history": dislocation in Toni Morrison's fiction
No full textThis thesis examines the trope of 'dislocation' within the later novels of Toni Morrison, identifying it as central to her representation ot African American history and experience. Organising my project around the theme and figure of dislocation allows me to bring together diverse considerations such as those of the geographical, communal, familial, cultural, corporeal and narrative displacements that preoccupy Morrison's fiction. Developing a line of enquiry neglected within the field of scholarship addressing Morrison's work, most importantly my thesis finds this term useful for negotiating the author's engagement with the diaspora engendered by racial slavery. In particular, it explores her evocation of the black diaspora as a configuration encompassing sites of remembering, affirmation and potentiality as well as processes of displacement, disruption, deracination and loss.
My research is informed by a broad range of critical resources but especially Edouard Glissant's and Paul Gilroy's theories of diasporic interaction. Tracing symbolic spatial trajectories and enabling and disabling relationships to the past, I investigate Morrison's imaginary in terms of a black Atlantic of roots and routes, patterns of traversal, connection and exchange. Rejecting a narrowly defined notion of African American Studies, this thesis seeks to extend the ways in which Morrison's novels are approached, locating in them a truly diasporic vision
Te Toi Poto, Te Toi Roa A Critical Evaluation of Māori-State Inclusion in the Ohiwa Harbour Strategy, Aotearoa New Zealand.
No full textIn New Zealand, the State Owned Enterprises Act 1988 [SOE], Local Government Act 2002 [LGA], the Resource Management Act 1991 [RMA] require that government include the voices of Māori, and ensure their contribution to the decision-making processes of local authorities. Accordingly, central and local government have embraced the idea of inclusive partnership as part of policymaking processes informed by shared values both of government and iwi.
Thus, it is not uncommon to see consultations, partnerships and engagement between Māori-state on a range of issues in line with Tikanga and protocols of Māori culture. These transitions reflect contemporary critical policy scholarship that underscores the need to include marginalised voices policymaking, specifically through processes that reflect diverse values. Termed here as ‘procedural inclusion’, these efforts are framed within the wider goal of participatory democracy as part of the efforts to realise an inclusive society. The present research is a critical evaluation of the inclusion of Māori in the processes of policymaking, especially when those processes have been especially designed to be culturally sensitive.
This core objective is developed through the analysis of the case study of iwi/hapū-local government engagement in creating and implementing the Ohiwa Harbour Strategy in New Zealand’s Eastern Bay of Plenty region between 2002- 2008. The strategy engagement, which culminated in a long-term plan to manage and conserve the Ohiwa harbour, is uniquely positioned for this investigation. It is often regarded by its iwi/hapū and local government stakeholders as a success story in iwi/hapū-government engagement. Using a critical qualitative research methodology informed by kaupapa Māori, the study sought to critically evaluate this exemplar of procedural inclusion at multiple levels. At an operational policy level, the research identified the factors that either facilitated or inhibited Māori inclusion in the strategy development process. At another, more substantive level, the study explored the politics of this engagement, and if the goals of procedural inclusion could accommodate the transformative claims of self-determination and kaitiakitanga made by iwi/hapū.
The analysis of interview data with key stakeholders and documents of the strategy process revealed that a range of factors enhance inclusive policymaking for Māori. At a practical level, legislative frameworks, commitment to Tikanga by all parties, and key strategic cultural brokers facilitated the inclusion of Māori, while limited capacity, fear of change and inter-tribal tensions hinder inclusion. The results also show, at another level, that the ability to productively participate in these engagement processes are framed by discursive politics – of the meanings and interpretations emanating from historical contexts, nature of power relationships, and of decisions regarding who represents whom and what is represented. In all, the study points to both advantages and limitations of procedural inclusion. Inclusive policymaking can open possibilities for better management of environmental resources, strengthening Māori political voice, and creating opportunities for livelihoods and with it greater economic and social inclusion. Equally, there are also limits of government-sponsored engagement.
Māori inclusion in policymaking, while positive, does not deliver opportunities for self determination or rangatiratanga in keeping with the Treaty principles of partnership
What to do when you've tried it all: the development and pilot evaluation of a skills group for the parents of anxious youth
No full textResearch has identified a role for parenting behaviors in the maintenance of child and adolescent anxiety disorders (McCleod, Wood, & Weisz, 2007). This paper reviews the experimental and theoretical literature on the relationship between parenting and youth anxiety as well as the empirical support for parent involvement in child cognitive behavioral therapy (CBT). The present study describes the development and pilot evaluation of a brief cognitive-behaviorally oriented parent treatment group (CBT+PG) designed to augment individual child CBT for anxiety and presents a conceptual model on which the group is based, focusing on the relationship between parenting behaviors, parent and child distress, parental experiential avoidance, and youth anxiety. This study reports preliminary findings, including feasibility and acceptability of the program based on participant and expert feedback. It also includes case descriptions of three families who participated in the CBT+PG program and three families who received only individual child CBT. Preliminary results support the feasibility and acceptability of running this program in an outpatient setting. Parents were satisfied with the program (M=29.2, SD=.24, possible range=9-36), expert reviewers received it favorably (M=6.4, SD=.26, possible range=1-7), and it appeared to bestow some clinical benefits. This study was unique in that it assessed parenting behaviors, parental experiential avoidance, and parent psychopathology in addition to child outcomes. Discussion elaborates upon the role of these variables and implications for future research and practice involving parents in child anxiety treatment.Psy. D.Includes bibliographical referencesby Rachel A. Merso
Measuring outcomes for Oregon's children, youth, and families
No full text[Report] -- Appendix of measures for Building results III.Clara C. Pratt, Ph.D., Aphra Katzev, Ph.D., Rachel Ozretich, M.S., Tammy Henderson, M.S., William McGuigan, M.S., Oregon State University, Family Policy Program ; prepared for the Oregon Commission on Children and Farnilies.Title from PDF title page (viewed on July 21, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 267-280) and indexes.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
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