25,364 research outputs found

    Diana M. Simmons congratulates UTSA students Morris Webster and David Soto

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    Diana M. Simmons, South Texas Regional Blood Bank donor recruitment consultant, congratulates UTSA student Morris Webster of the Baptist Student Union and David Soto of Kappa Sigma fraternity after presenting them with community service awards from the blood bank

    Alzheimer’s Disease: The Challenge of the Second Century

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    In the first of our State of the Art Review series, David M. Holtzman, John C. Morris, and Alison M. Goate explore the rapid pace of Alzheimer’s disease research and the challenges to translating research breakthroughs into clinical treatments.</jats:p

    Analytic aspects of cyclosporine monitoring, on behalf of the IFCC/IATDMCT joint working group

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    The use of therapeutic drug monitoring strategies for cyclosporin (CsA) has evolved markedly in recent years since previous consensus guidelines were presented. Apart from the introduction of some new methods, the major change has been the shift away from the traditional predose/trough (C0) sample. The most popular alternative has been shown to be a 2-hour postdose (C2) sample. This has presented a challenge to clinical laboratories where typical C2 sample concentrations exceed the upper limit of the calibration range for their chosen CsA method, hence requiring an accurate dilution to be performed. Data from the Australian/New Zealand survey, as well as that in the International CsA Proficiency Testing Program, have demonstrated both a plethora of dilution protocols and resultant widespread failure of many laboratories to obtain accurate results. This paper compares data from several independent sources, pointing to international problems for reliable CsA measurement in clinical laboratories. This includes the CsA method selection criteria adopted by a large percentage of laboratories in various surveys, indicating that the least specific mFPIA methods have been widely adopted.Raymond G. Morris, David W. Holt, Victor W. Armstrong, Andrea Griesmacher, Kimberly L. Napoli, and Leslie M. Sha
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