36 research outputs found
Inflatable: Twist
No full textStudents designed and manufactured these large scale inflatable sculptures that will be interactively on display on the Dell during SSS. The process of their creation involved creating smaller models, learning to sew and creating patterns that could be amplified to a larger scale. The inflatables are made with a rip-stop nylon parachute material, and allow students to create large-scale sculptures that interact with viewers
Debating mental health nurses' role in medicines management
No full textThis article delineates concordance and adherence; two fundamental positions pertaining to the role of the nurse in medicine management. Taking the form of a debate, it uses mental health nursing to describe the role and function of concordance and adherence in practice. Each author presents their case and responds briefly to the other in order to show why they see the adoption of one term or another as central to medicines interventions with the patient. The purpose of the paper is to encourage readers to consider their own position in relation to this important debate
Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues.
No full textMigration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues.
No full textDendritic cells (DC) are critical accessory cells for primary immune responses and they may be important stimulators of transplantation reactions, but little is known of their traffic into the tissues. We have studied the migration of purified splenic DC and T lymphocytes, labeled with 111Indium-tropolone, in syngeneic and allogeneic mice. First we demonstrate that DC can migrate from the blood into some lymphoid and nonlymphoid tissues. Immediately after intravenous administration, radio-labeled DC were sequestered in the lungs, but they actively migrated into the liver and spleen and reached equilibrium levels between 3 and 24 h after transfer. At least half of the radiolabel accumulated in the liver, but the spleen was the principal site of DC localization in terms of specific activity (radiolabel per weight of tissue). DC were unable to enter Peyer's patches, or mesenteric and other peripheral lymph nodes from the bloodstream. This was also true in splenectomized recipients, where the otherwise spleen-seeking DC were quantitatively diverted to the liver. In contrast, T cells homed readily to the spleen and lymph nodes of normal mice and increased numbers were present in these tissues in splenectomized mice. Thus, unlike T cells, DC cannot recirculate from blood to lymph via the nodes. We then show that migration of DC from the blood into the spleen is dependent on the presence of T cells: DC did not enter the spleens of nude mice, but when they were reconstituted with T cells the numbers entering the spleen resembled those in euthymic mice. In nude mice, as in splenectomized recipients, the DC that would normally enter the spleen were quantitatively diverted to the liver. These findings suggest that there is a spleen-liver equilibrium for DC, that may be akin to that existing between spleen and lymph node for T cells. Finally, we followed the traffic of radiolabeled DC via the afferent lymphatics after subcutaneous footpad inoculation. DC accumulated in the popliteal nodes but did not migrate further to the inguinal nodes. There was no difference between euthymic and nude mice, showing that unlike traffic to the spleen, this route probably does not require T cells. These migration patterns were not affected by major histocompatibility barriers, and were only seen with viable, but not glutaraldehyde-fixed, DC.(ABSTRACT TRUNCATED AT 400 WORDS
T cell activation by anti‐CD3 antibodies: function of Fc receptors on B cell blasts, but not resting B cells, and CD18 on the responding T cells
No full textBee Venom Therapy for the Treatment of Lyme Disease
No full textLyme Disease is a tick borne illness, caused from a bacterial infection as a result of being bitten by a tick. Traditionally, lyme disease is treated with antibiotics, such as doxycycline and amoxicillin. However, there are so many patients who have long lasting symptoms from lyme disease whether they were treated with antibiotics or not. There is new research that suggests the use of bee venom for therapeutic use can be an effective form of antimicrobial treatment for B. burgdorferi, which is the pathogen responsible for lyme disease. By examining existing research from 2019 to 2024, this review synthesizes findings from various quantitative and qualitative studies, through systematic reviews and meta-analysis. The findings show that bee venom therapy, as opposed to traditional antibiotic therapy, contains Melittin, a strong anti-inflammatory that induces cortisol, Apamin, a mild neurotoxin that increases the production of cortisol within the adrenal gland, and Adolapin, which acts as an additional form of anti-inflammatory and an analgesic. As a result, bee venom therapy uses these pharmacological components to intensify the management of symptoms that come from long-lasting lyme disease pain. Through research the goal is to recommend that the use of bee venom can be an effective form of treatment for lymes disease symptom management, instead of the antibiotics that are typically ordered
Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone.
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Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.
No full textPlasmodium falciparum:Rosettes do not protect merozoites from invasion-inhibitory antibodies
No full textRosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions. Previous work showed that rosetting does not enhance parasite invasion under standard in vitro conditions. We hypothesised that rosetting might promote invasion in the presence of host invasion-inhibitory antibodies, by allowing merozoites direct entry into the erythrocytes in the rosette and so minimising exposure to plasma antibodies. We therefore investigated whether rosetting influences invasion in the presence of invasion-inhibitory antibodies to MSP-1. We found no difference in invasion rates between isogenic rosetting and non-rosetting lines from two parasite strains, R29 and TM284, in the presence of MSP-1 antibodies (P = 0.62 and P = 0.63, Student's t test, TM284 and R29, respectively). These results do not support the hypothesis that rosettes protect merozoites from inhibitory antibodies during invasion. The biological function of rosetting remains unknown
