432 research outputs found
Dialogue between Death and a Sinner
No full textConversation between Death and a sinner; Ladies and Gentlemen, it is true that some trades are flourishing while others are in a state of starvation. The bearers are, and have been out of employment a considerable time, and they offer these few verses for sale, hoping that you will become purchasers.https://egrove.olemiss.edu/kgbsides_scot/1003/thumbnail.jp
Defining the brand SINNER: Proposing a new strategic vision and creating a brand book
No full textSINNER - the primary stakeholder in this thesis - is known as a sports eyewear company that focuses on winter sports. With the ambition to gain more brand awareness throughout the Netherlands and eventually worldwide, multiple aspects of the brand have to be made clearer in order to create a stronger brand. Brands need to innovate in order to maintain their position in the market. When a brand gets tired, it might require revitalization, also known as repositioning (Beverland, 2018). The conducted internal analysis is the basis for defining the brand, the external analysis has created input to understand the segment where SINNER can position itself and realize its competitive advantage. The literature review has been used to define how to strengthened a brand. Based on these analyses the positioning and proposition were set up. Additionally, a purpose, mission and vision were determined and used in the brand DNA of SINNER. To communicate all of these elements, the design principles were set up. These design principles are applied in the brand book, which explains what the brand is about, how the brand communicates and how this communication looks when visualized. The brand book is the ultimate deliverable and shows how the new brand strategy enables internal alignment and consistency. The outcomes for this thesis are: An analysis, providing an understanding of what the brand SINNER is about A new design strategy, describing the new brand identity A brand book that presents the new brand identity Brand touchpoints that visualize the translation from brand book to design In the end several recommendations are done, to apply the results in order to give the SINNER brand a new and reinforced appearance.Strategic Product Desig
Dante’s Davidic journey: from sinner to psalmist
No full textDante’s debt to the Psalms—the biblical book that, to many of its interpreters, contained the wisdom of the whole Bible in its words— is widely acknowledged, as is the influence of the biblical figure whom he believed to be its single author: King David.¹ In Dante’s time, David was considered a sinner, a penitent, a just man, and an exemplary ruler. He was the psalmist, a divinely inspired auctor, a prophet, and a figure of Christ to come
The uses of madness in nineteenth- and twentieth-century fiction : the relation between narrative strategy and disturbed states of consciousness
No full textThe thesis operates upon the premise that there has been, in the
course of the last two centuries, a radical transformation in narrative
presentations of exceptional states of consciousness. It sets out to
identify the main characteristics of the fictional transformation, and to
situate them in the context of wider cultural shifts. I decided to rest
my approach upon the relatively conservative sense that, roughly speaking,
the structural and linguistic analysis of a narrative topos - that is to
say the protagonist's madness - can elicit a clearer understanding of the
changing, underlying dynamics and thematics of fictional works as they
emerge over a given historical period.
The thesis is set out in two parts; Part I explores nineteenth
century uses of madness, and Part II compares and contrasts more recent
treatments. The study of the different presentations of madness in
fiction is organized diachronically for heuristic purposes, although the
typological emphasis of the thesis must eventually take precedence over
the imposition of a rigid historical framework.
In the nineteenth century it is predominantly an intellectually
marginalized kind of fiction (often termed 'gothic') which deals with
exceptional psychic experience. It does so in a way which engages with
the treacherous 'otherness' of mad experience, which is often aligned with
the supernatural. In these texts the position of the narrator in relation
to such phenomenon is of paramount importance. More recent treatments of
'madness' display a tendency to undermine its 'otherness' and to move
towards narrative identification with such states.
The method of investigation functions upon several levels. In order
to provide a constructive counter-perspective upon fictional treatments of
madness and to forge the link with contemporary methodologies, the study
commences with the narratological analysis of a work written by a
(clinically diagnosed) psychotic author which has achieved the status of a
classic within psychiatric, psychoanalytical and even recent cultural
theory. The narrative structure of D. P. Schreber's Memoirs finds its
equivalent in a kind of fiction identified in this thesis as 'paranoid'.
Twentieth century clinical discourse increasingly has recourse to the
very broad term 'schizophrenia' as a synonym for the outmoded term
'madness'. The current emphasis upon linguistic concerns in the definition
and location of psychosis allows the critical grouping of certain kinds of
texts under the heading of 'schizoid', due to the discovery of analogous
characteristics at work within their (anti)narrative strategy. Again, these
terms are heuristically intended and cannot be scientifically precise. The
thesis concludes with a discussion of the current centrality of a
terminology of psychopathology to the ways in which fictionists, critics
and theorists describe, prescribe and understand the 'postmodern' self and
world.
This project offers an overview of attitudes to madness as they are
transformed in fiction in the course of a historical period. The way in
which madness functions in these texts is, first of all, not only as the
instrument of literary exploration but also as a means of transgressing
boundaries between sanity and insanity. The period is crucial, further, in
its radical transitional nature with regard to concepts of fundamental
import for the novel form: most particularly, ideas of the 'self' and ideas
of 'reality', as objectively stable or as sub. iective and illusory. For the
fictional articulation of these, the topos of 'madness' serves as the
ultimate measure
James Hogg's Confessions of a justified sinner and the romantic roots of crime fiction
No full textThe author attempts to situate James Hogg’s The Private Memoirs and Confessions of a Justified Sinner (1824) as a key text in the proto-history of crime fiction. Hogg’s novel is considered alongside the early crime fiction of William Godwin and Charles Brockden Brown, and the cultural milieu of the 1820s, specifically Blackwood’s “tales of terror” and the work of Thomas De Quincey. Reading Hogg’s novel in this way reasserts the somewhat overlooked origins of crime fiction within the broader contexts of romanticism
A Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation
No full textBackground— Congestive heart failure (CHF) causes atrial fibrotic remodeling, a substrate for atrial fibrillation (AF) maintenance. MicroRNA29 (miR29) targets extracellular matrix proteins. In the present study, we examined miR29b changes in patients with AF and/or CHF and in a CHF-related AF animal model and assessed its potential role in controlling atrial fibrous tissue production. Methods and Results— Control dogs were compared with dogs subjected to ventricular tachypacing for 24 hours, 1 week, or 2 weeks to induce CHF. Atrial miR29b expression decreased within 24 hours in both whole atrial tissue and atrial fibroblasts (−87% and −92% versus control, respectively; p <0.001 for both) and remained decreased throughout the time course. Expression of miR29b extracellular matrix target genes collagen-1A1 (COL1A1), collagen-3A1 (COL3A1), and fibrillin increased significantly in CHF fibroblasts. Lentivirus-mediated miR29b knockdown in canine atrial fibroblasts (−68%; p <0.01) enhanced COL1A1, COL3A1, and fibrillin mRNA expression by 28% ( p <0.01), 19% ( p <0.05), and 20% ( p <0.05), respectively, versus empty virus–infected fibroblasts and increased COL1A1 protein expression by 90% ( p <0.05). In contrast, 3-fold overexpression of miR29b decreased COL1A1, COL3A1, and fibrillin mRNA by 65%, 62%, and 61% (all p <0.001), respectively, versus scrambled control and decreased COL1A1 protein by 60% ( p <0.05). MiR29b plasma levels were decreased in patients with CHF or AF (by 53% and 54%, respectively; both p <0.001) and were further decreased in patients with both AF and CHF (by 84%; p <0.001). MiR29b expression was also reduced in the atria of chronic AF patients (by 54% versus sinus rhythm; p <0.05). Adenoassociated viral–mediated knockdown of miR29b in mice significantly increased atrial COL1A1 mRNA expression and cardiac tissue collagen content. Conclusions— MiR29 likely plays a role in atrial fibrotic remodeling and may have value as a biomarker and/or therapeutic target.Background— Congestive heart failure (CHF) causes atrial fibrotic remodeling, a substrate for atrial fibrillation (AF) maintenance. MicroRNA29 (miR29) targets extracellular matrix proteins. In the present study, we examined miR29b changes in patients with AF and/or CHF and in a CHF-related AF animal model and assessed its potential role in controlling atrial fibrous tissue production. Methods and Results— Control dogs were compared with dogs subjected to ventricular tachypacing for 24 hours, 1 week, or 2 weeks to induce CHF. Atrial miR29b expression decreased within 24 hours in both whole atrial tissue and atrial fibroblasts (−87% and −92% versus control, respectively; p <0.001 for both) and remained decreased throughout the time course. Expression of miR29b extracellular matrix target genes collagen-1A1 (COL1A1), collagen-3A1 (COL3A1), and fibrillin increased significantly in CHF fibroblasts. Lentivirus-mediated miR29b knockdown in canine atrial fibroblasts (−68%; p <0.01) enhanced COL1A1, COL3A1, and fibrillin mRNA expression by 28% ( p <0.01), 19% ( p <0.05), and 20% ( p <0.05), respectively, versus empty virus–infected fibroblasts and increased COL1A1 protein expression by 90% ( p <0.05). In contrast, 3-fold overexpression of miR29b decreased COL1A1, COL3A1, and fibrillin mRNA by 65%, 62%, and 61% (all p <0.001), respectively, versus scrambled control and decreased COL1A1 protein by 60% ( p <0.05). MiR29b plasma levels were decreased in patients with CHF or AF (by 53% and 54%, respectively; both p <0.001) and were further decreased in patients with both AF and CHF (by 84%; p <0.001). MiR29b expression was also reduced in the atria of chronic AF patients (by 54% versus sinus rhythm; p <0.05). Adenoassociated viral–mediated knockdown of miR29b in mice significantly increased atrial COL1A1 mRNA expression and cardiac tissue collagen content. Conclusions— MiR29 likely plays a role in atrial fibrotic remodeling and may have value as a biomarker and/or therapeutic target
Dan Tucker
No full textStory of unlucky sinner Dan Tuckerhttps://egrove.olemiss.edu/kgbsides_uk/1362/thumbnail.jp
Analysis of Single Nucleotide Polymorphisms of the NOS1 and NOS3 genes: Association with Atrial Fibrillation
No full textDie Erforschung der genetischen Komponente von häufigen Erkrankungen wie Vorhofflimmern (VHF) wird immer wichtiger. Auf dieser Basis wurden in einer Kandidatengen-basierten, genetischen Assoziationsstudie drei single nucleotide polymorphisms (SNPs) der Gene NOS1 und NOS3 genotypisiert. Es zeigte sich, dass der SNP rs1799983 (E289D) im NOS3-Gen grenzwertig mit VHF assoziiert ist. In einer Subgruppenanalyse konnte für Patienten unter 60 Jahren sowie für Frauen eine signifikante Assoziation des SNP mit der Erkrankung nachgewiesen werden. Eine ausführliche Diskussion der Ergebnisse beleuchtet insbesondere auch die Limitationen des vorliegenden Studientyps.The investigation of the genetic component of common diseases like atrial fibrillation (AF) is becoming more and more important. Three single nucleotide polymorphisms (SNPs) from the NOS1 and NOS3 genes were genotyped in a genetic association study based on a candidate-gene approach. A borderline positive association was shown between AF and the NOS3 SNP rs1799983 (E298D). A subgroup analysis of patients below the age of 60 as well as of women revealed a significant association between SNP and disease. A comprehensive discussion section also highlights the limitations of the used study type
The death of William Golding: authorship and creativity in darkness visible and the paper men
No full textIn the seventies and eighties William Golding was deeply responsive to the critical, anti-authorial ethos that followed the publication of Roland Barthes's "La mort de I'auteur" (1968). In Darkness Visible (1979) and The Paper Men (1984) he investigates means by which to reaffirm authorial presence. Working through paradox, he performs the authorial death in these novels, and establishes language’s inadequacy as a means of conveying absolute meaning, authorial "vision," truth or revelation. Having done so he nonetheless gestures towards the divine, towards the possibility of a vatic communication. In this manner the novels work upon principles of contradiction and collapse. What remains is a discourse of hope, promise, desire, without means of substantiating such optimism. Thus Golding might be said to have practiced a form of negative theology, and to have anticipated in this respect some recent trends in literary theory
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