55 research outputs found
Catalytic and Selective Conversion of Glycine into Serine by the Reaction with Formaldehyde in a Neutral Aqueous Solution.
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Datasets produced by SCALE-GM in QBO-like oscillation experiments.
No full textData produced by SCALE-GM and used in the manuscript submitted to the AMS journal Monthly Weather Review.
Authors:
Hiroki Kashimura, Hisashi Yashiro, Seiya Nishizawa, Hirofumi Tomita, Kensuke Nakajima, Masaki Ishiwatari, Yoshiyuki O. Takahashi, and Yoshi-Yuki Hayashi
Corresponding Author:
Hiroki Kashimura ([email protected])
Manuscript Title:
Dependence of a QBO-like oscillation on time-step intervals in a non-hydrostatic general circulation model
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An International Comparison of Corporate Investment Behavior: Some Implications for the Governance Structure in Japan
No full textValidation of high-resolution aerosol optical thickness simulated by a global non-hydrostatic model against remote sensing measurements
No full textSupplement to the Studies on the Pathogenic Agent of "Izumi Fever" I: Chronic Infectious Course by the Pathogenic Agent of "Iznmi Fever"
No full textIt is well-known that the virus of "Izumi fever" is well preserved and even its serial passage is feasible by inoculation of the virus into the mouse. It is also inferred, however, that some alteration in virus multiplication or pathological changes will occur during the course of chronic infection. In order to study these points in the chronic infectious course, the author inoculated the virus into mice, killed them on the previously decided days, and studied the infectious aspect and infectious degree in detail by observation of the pathological findings. These observations were compared with those in chronic infectious course of infectious hepatitis, hereby a certain conclusion was obtained. The infection was well established and lasted for a long time by both of Yashiro and Mitsui strains. Two weeks after the inoculation of the virus, degeneration and necrosis of parenchymal cells and cell infiltration were observed in the liver, which suggested that these pathological changes had been occurring repeatedly. In the lung, septal interstitial pneumonitis and cell infiltration appeared. From these findings, Yashiro and Mitsui strains are concluded to be the virus of the same nature.
These pathological findings are quite alike to those reported by Murakami et al. on the hepatitis virus; it appeared to be almost impossible to discriminate between these two sorts of viruses by the findings in chronic infectious course alone
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
No full textMutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to synaptic alterations, we investigated synaptic ultrastructure and function in presymptomatic CTSD knockout (Ctsd) mice. Electron microscopy revealed that there were significantly greater numbers of readily releasable synaptic vesicles present in Ctsd mice than in wild-type control mice as early as postnatal day 16. The size of this synaptic vesicle pool continued to increase with disease progression in the hippocampus and thalamus of the Ctsd mice. Electrophysiology revealed a markedly decreased frequency of miniature excitatory postsynaptic currents (mEPSCs) with no effect on paired-pulse modulation of the evoked excitatory post synaptic potentials in the hippocampus of Ctsd mice. The reduced mEPSCs frequency was observed before the appearance of epilepsy or any morphologic sign of synaptic degeneration. Taken together, these data indicate that CTSD is required for normal synaptic function and that a failure in synaptic trafficking or recycling may bean early and important pathologic mechanism in Ctsd mice; these presynaptic abnormalities may initiate synaptic degeneration in advance of subsequent neuronal loss
泉熱病毒に関する知見補遺 第一編 泉熱病毒による慢性化実験
No full textIt is well-known that the virus of "Izumi fever" is well preserved and even its serial passage is feasible by inoculation of the virus into the mouse. It is also inferred, however, that some alteration in virus multiplication or pathological changes will occur during the course of chronic infection. In order to study these points in the chronic infectious course, the author inoculated the virus into mice, killed them on the previously decided days, and studied the infectious aspect and infectious degree in detail by observation of the pathological findings. These observations were compared with those in chronic infectious course of infectious hepatitis, hereby a certain conclusion was obtained. The infection was well established and lasted for a long time by both of Yashiro and Mitsui strains. Two weeks after the inoculation of the virus, degeneration and necrosis of parenchymal cells and cell infiltration were observed in the liver, which suggested that these pathological changes had been occurring repeatedly. In the lung, septal interstitial pneumonitis and cell infiltration appeared. From these findings, Yashiro and Mitsui strains are concluded to be the virus of the same nature.
These pathological findings are quite alike to those reported by Murakami et al. on the hepatitis virus; it appeared to be almost impossible to discriminate between these two sorts of viruses by the findings in chronic infectious course alone
Highly-sophisticated Utilization of Itaconic Anhydride. I. Syntheses of Unsymmetric Tetracarboxylic Acid Derivatives Having a Quarternary Carbon and Formation of Carbamoyl-substituted Imides by the Reaction with Primary Amines.
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