8,651 research outputs found
Book review : Japan and Africa by Jun Morikawa
No full textReview of: Jun Morikawa. Japan and Africa. London: Hurst & Co.; Johannesburg: Witwatersrand University Press, 199
Whaling in Japan: Power, Politics and Diplomacy
No full textJun Morikawahttp://trove.nla.gov.au/work/3171436
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
Before main banks : a selective historical overview of Japan's prewar financialsystem
No full textThe postwar experience of the Japanese banking system has received considerable attention recently partly because conditions in defeated Japan in 1945 (including high inflation and the need to switch from a military to a civilian economy) are similar to those in transition economies today. Policymakers in transition economies can learn a good deal from the experiences of Japan's postwar financial system but should remember that Japan also experienced extraordinary industrial growth and financial institution building in the late nineteenth and early twentieth centuries. Lessons to be learned from that experience include the following: Business conglomerates that did not continue to depend on government patronage were more successful than others in making the transition to a modern industrial economy. Banks that made a conscious effort to reduce their dependence on central bank credit were more successful than those that did not. The establishment of procedures for punishing defaulting borrowers helped the development of the payments system. Limits on the amount of lending to related parties appear to have contributed to financial stability (and could have contributed more if the newer"zaibatsu"had been as prudent as the older ones). Bank bailouts without accompanying reform (such as those the Bank of Japan undertook in 1920 and 1922) probably increased the likelihood of a more serious crisis, such as that of 1927. Capital standards - the minimum capital requirements established in the 1927 law - were a viable means of encouraging bank consolidation and more prudent lending. The public financial system served as a buffer when the banking sector was downsized.Banks&Banking Reform,Payment Systems&Infrastructure,Financial Intermediation,Financial Crisis Management&Restructuring,Decentralization,Financial Intermediation,Financial Crisis Management&Restructuring,Municipal Financial Management,Banking Law,Banks&Banking Reform
Memories of Professor Morikawa Makio
No full text追悼特集--森川眞規雄先生(In memory of Professor Morikawa Makio)森川眞規雄先生と私 / 秋庭裕 [著]ありがとう、すみません : 森川眞規雄先生を偲んで / 逄軍 [著]追憶 : 森川眞規雄先生との日々 / 河口充勇 [著]森川眞規雄先生を偲んで / 藤本昌代 [著]森川先生からいただいた絵 / 板垣竜太 [著]森川先生のこと / 小林久高 [著]森川さんのことば / 尾嶋史章 [著]森川眞規雄先生を悼む / 立木茂雄 [著]生活史研究会の思い出とその後 / 鵜飼孝造 [著]departmental bulletin pape
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No full textauthorIn other places [Old Joe, the trapper] pointed out otter (or, as he pronounced it, "author") slidesPRINTED ITEM G.M.Story April 1959Not UsedNot UsedWithdrawn[see 'otter']Checked by Jordyn Hughes on Thu 09 Jun 201
Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang
No full textWong, Chai Kwok = 加入聚合物對均勻湍流及均勻湍流對流的影響 / 黃濟國.Thesis M.Phil. Chinese University of Hong Kong 2013.Includes bibliographical references (leaves 89-91).Abstracts also in Chinese.Title from PDF title page (viewed on 01, November, 2016).Wong, Chai Kwok = Jia ru ju he wu dui jun yun tuan liu ji jun yun tuan liu dui liu de ying xiang / Huang Jiguo
Author Correction: Manipulating anion intercalation enables a high-voltage aqueous dual ion battery
No full textThe original version of this Article did not acknowledge Prof. Jun Fan as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.link_to_subscribed_fulltex
Giant liposarcoma of the spermatic cord: a case report
No full textA case of giant liposarcoma of the spermatic cord was reported. A 75-year-old man was admitted with a 25-year history of a slowly growing left scrotal solid mass without trans-illumination. The removed huge mass measuring 26.0 x 16.5 x 20.0 cm and weighing 4, 500 g was confirmed to be a well-differentiated liposarcoma according to WHO classification. The patient died of acute pneumonia 5 months later, although the postoperative course was uneventful and he had no sign of recurrence
Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy
No full textKurita Y, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Tsubouchi K, Sato N, Yoshida M, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Kuwano K. Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy. Respir Res. 2017 Jun 2;18(1):114. doi: 10.1186/s12931-017-0600-3. PMID: 28577568; PMCID: PMC5457546
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