4,656 research outputs found
Self-Serv: a platform for rapid composition of web services in a peer-to-peer environment
No full textQuan Z. Sheng, Boualem Benatallah, Marlon Dumas and Eileen Oi-Yan Ma
The Postsynaptic Organization of Synapses
No full textThe postsynaptic side of the synapse is specialized to receive the neurotransmitter signal released from the presynaptic terminal and transduce it into electrical and biochemical changes in the postsynaptic cell. The cardinal functional components of the postsynaptic specialization of excitatory and inhibitory synapses are the ionotropic receptors (ligand-gated channels) for glutamate and g-aminobutyric acid (GABA), respectively. These receptor channels are concentrated at the postsynaptic membrane and embedded in a dense and rich protein network comprised of anchoring and scaffolding molecules, signaling enzymes, cytoskeletal components, as well as other membrane proteins. Excitatory and inhibitory postsynaptic specializations are quite different in molecular organization. The postsynaptic density of excitatory synapses is especially complex and dynamic in composition and regulation; it contains hundreds of different proteins, many of which are required for cognitive function and implicated in psychiatric illness
Tropilaelaps mercedesae Anderson & Morgan 2007
No full text63. Tropilaelaps mercedesae Anderson & Morgan, 2007 Host/Habitat. Apis mellifera (Western honey bee). Distribution. Yuncheng (as Yunchen [sic]), Changzhi, Yangquan (Luo et al. 2011). Remarks. The Tropilaelaps mite in China had long been incorrectly called Tropilaelaps clareae. Its identity was recently clarified by Luo et al. (2011). There is only one species, T. mercedesae present in China. Macrochelidae Vitzthum, 1930 (8 species in 2 genera)Published as part of Ma, Min, Li, Sheng-Cai & Fan, Qing-Hai, 2015, Mites and ticks (Acari) in Shanxi Province, China: an annotated checklist, pp. 1-39 in Zootaxa 4006 (1) on page 12, DOI: 10.11646/zootaxa.4006.1.1, http://zenodo.org/record/28926
Characterization of the Shank family of synaptic proteins - Multiple genes, alternative splicing, and differential expression in brain and development
No full textShank1, Shank2, and Shank3 constitute a family of proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank directly interacts with GKAP and Homer, thus potentially bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex in synapses (Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, S., Valtschanoff, J., Weinberg, R J., morley, P. F., and Sheng, M. (1999) Neuron 23, 569-582; Tu, J. C., Xiao, B., Naisbitt, S., Yuan, J. P., Petralia, R. S., Brakeman, P., Dean, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., and Worley, P. F. (1999) Neuron 23, 583-592). Shank contains multiple domains for protein-protein interaction including ankyrin repeats, an SH3 domain, a PSD-95/DIg/ZO-1 domain, a sterile a motif domain, and a proline-rich region. By characterizing Shank cDNA clones and RT-PCR products, we found that there are four sites far alternative splicing in Shank1 and another four sites in Shank2, some of which result in deletion of specific domains of the Shank protein. In addition, the expression of the splice variants is differentially regulated in different regions of rat brain during development. Immunoblot analysis of Shank proteins in rat brain using five different Shank antibodies reveals marked heterogeneity in size (120-240 kDa) and differential. spatiotemporal expression. Shank1 immunoreactivity is concentrated at excitatory synaptic sites in adult brain, and the punctate staining of Shank1 is seen in developing rat brains as early as postnatal day 7. These results suggest that alternative splicing in the Shank family may be a mechanism that regulates the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain
An efficient predistorter design for compensating nonlinear memory high power amplifier
No full textThis contribution applies digital predistorter to compensate distortions caused by memory high power amplifiers (HPAs) which exhibit true output saturation characteristics. Particle swarm optimization is first implemented to identify the Wiener HPA’s parameters. The estimated Wiener HPA model is then directly used to design the predistorter. The proposed digital predistorter solution is attractive owing to its low on-line computational complexity, small memory units required and simple VLSI hardware structure implementation. Moreover, the designed predistorter is capable of successfully compensating serious nonlinear distortions and memory effects caused by the memory HPA operating in the output saturation region. Simulation results obtained are presented to demonstrate the effectiveness of this novel digital predistorter design
Author Correction: IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
No full textSheng X, Nenseth HZ, Qu S, et al. Author Correction: IRE1alpha-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nature Communications . 2024;15(1): 6190
Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses
No full textSynaptic adhesion molecules regulate multiple steps of synapse formation and maturation. The great diversity of neuronal synapses predicts the presence of a large number of adhesion molecules that control synapse formation through trans-synaptic and heterophilic adhesion. We identified a previously unknown trans-synaptic interaction between netrin-G ligand-3 (NGL-3), a postsynaptic density (PSD) 95-interacting postsynaptic adhesion molecule, and leukocyte common antigen-related (LAR), a receptor protein tyrosine phosphatase. NGL-3 and LAR expressed in heterologous cells induced pre-and postsynaptic differentiation in contacting axons and dendrites of cocultured rat hippocampal neurons, respectively. Neuronal overexpression of NGL-3 increased presynaptic contacts on dendrites of transfected neurons. Direct aggregation of NGL-3 on dendrites induced coclustering of excitatory postsynaptic proteins. Knockdown of NGL-3 reduced the number and function of excitatory synapses. Competitive inhibition by soluble LAR reduced NGL-3-induced presynaptic differentiation. These results suggest that the trans-synaptic adhesion between NGL-3 and LAR regulates excitatory synapse formation in a bidirectional manner.This work was supported by the National Creative Research Initiative Program of the Korean Ministry of Science and Technology (E.K.)
"Yi zhuan" "sheng sheng" si xiang yan jiu =: On the Idea of shengsheng in the commentaries of Yi
No full textPh.D.The thesis aims to investigate the idea of Shengsheng (continuous creation) in the Commentaries of Yi and its development in the history of Confucian philosophy. The investigation consists of four parts. The first part starts by discussing the literal meaning of the character Sheng in the oracle bone script and the Chinese bronze inscriptions. It then examines the idea of Shengsheng in the ancient Chinese classics, especially its textual context in the Commentaries of Yi . Accordingly, we will answer the following questions one by one: What is Shengsheng ? How can it actualize? How is the idea adopted by other Pre Qin thoughts? The second part focuses on the understanding of the idea in Han Confucianism. It takes Zhouyi Qianzhaodu and the Zheng Xuan interpretation as illustrative examples. Here we see how another idea Qi has been introduced to interpret Sheng sheng as the origin and process of actualization in both the natural world and human community. The third part moves to the development of the idea in Northern Song Confucianism and explores how the Confucian scholars at that time further elaborated the idea as an essential of moral metaphysics. The final part studies the thought of Xiong Shili to show how Xiong draws from Buddhism and Confucian philosophy to develop a critical inquiry into the idea and hence argues its modern relevance.本文以《易傳》「生生」觀念為研究對象。全文分為四部分，第一部分由考察甲骨、金文中「生」字之原義開始，依次分析並討論了早期文獻中所見之「生生」觀念及《易傳》所論「生生」之本義，包括何為《易傳》所論之「生生」，據《易傳》之說 ，「 生生」將何以實現，以及《易傳》「生生」觀念與先秦諸子思想之關係。第二部分通過以《周易乾鑿度》為切入點，考察了經學時代下學者們對《易傳》「生生」觀念的最有代表性的若干理解，包括據《乾鑿度》之理解 ，「 生生」當如何實現於天地萬物及人類社會之中，以及鄭康成所作之《乾鑿度注》之中包含的對「生生」 所以實現之根本與歷程的另一種思考。第三部分通過將北宋五子的詮釋作為典範，考察了理學思維下《易傳》「生生」觀念之詮釋理論的一般理論框架，包括理學思維下的「生生」之本質及「生生」之道德義之豁顯。第四部分則通過將熊十力《新唯識論（語體文本）》中關於《易傳》「生生」觀之詮釋作為代表，考察了現代哲學視域下的《易傳》「生生」觀念。竇晨光."2019年8月".Parallel title from added title page.Thesis Ph.D. Chinese University of Hong Kong 2019.Includes bibliographical references (leaves 334-340).Abstracts in Chinese and English.Title from PDF title page (viewed on February 23, 2022).Dou Chenguang
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