1,721,218 research outputs found
Dictionary for dementia stratification
No full textAbstracts were categorised into either 'Alzheimer', 'dementia', 'related dementia', 'unrelated dementia', or 'none'
CSV file: Supplementary Table 5
No full textSupplementary Table 5. Evidence breakdown for each pathway for genetic vs model and animal vs human. We excluded pathways with less than 100 papers from our analysis. There are overlaps between these comparisons, for example papers with a human tag could also have a genetics tag
Excel file: Supplementary Tables 1-9
No full textSupplementary Tables 1-9 for the publication "Are most pathways related to Alzheimer’s disease pathogenesis?
CSV file: Supplementary Table 8
No full textSupplementary Table 8. Enrichment for AD genes from Open Targets. Supplementary Table 2 was used as the input gene lists for this enrichment test. Only KEGG was used in this analysis
CSV file: Supplementary Table 7
No full textSupplementary Table 7. The pathways most targeted by symptomatic and disease-modifying treatments. We used Open Targets and Therapeutic Target Database to assign gene targets to drugs. Drugs were only counted once per pathway even if they targeted it via multiple genes. We did not correct for pathway size as larger pathways do not require more genes to be targeted to cause an effect
CSV file: Supplementary Table 6
No full textSupplementary Table 6. Pathway ranks annually since 1990. We ranked pathways based on their yearly publication record in association with dementia. If two+ pathways had the same number of papers, then the ranks were averaged to keep all years on the same scale
CSV file: Supplementary Table 1
No full textSupplementary Table 1. Scoring AD-pathway connections. When assessing a selection of 2-20 papers per pathway for their association to AD, we developed a scoring system to judge the strength of the evidence (Supplementary Table 1). Direct and obvious pathway associations scored 1 while loose, indirect connections scored 5. The type of dementia mentioned was also included in this score. AD papers could score the highest while related dementia, like frontotemporal dementia, could score a maximum of 3 and unrelated dementias could only achieve a 4
Dictionary for evidence types
No full textAbstracts were categorised as 'human', 'animal', 'both' or 'neither' for the first comparison. For the second comparison, 'genetic', 'model', 'both' or 'neither'. Lastly, 'inVivo', 'inVitro', 'both' or 'neither'. Words that overlapped between the same comparison were removed
CSV file: Supplementary Table 4
No full textSupplementary Table 4. Total paper counts and scores for each pathway’s association with dementia and AD via the literature. We investigated KEGG pathways plus three Reactome pathways and three added terms: immune system, cancer and diabetes. There was no significant difference between the pathway ranks from the whole of the dementia literature compared to AD-specific papers. The pathway_score was based on ~10 papers judging how often the paper fully related to the pathway. The AD-pathway_score is the average score for papers where the pathway's association to AD was judged based on 2-10 papers. More papers were assessed for pathways with fewer total papers. The AD_word_score is the average number of AD-specific words used in each paper assigned to each pathway, based on all associated papers
CSV file: Supplementary Table 3
No full textSupplementary Table 3. Genetically-associated AD genes from GWA and familial studies. Curated list of genes published with Alzheimer’s disease improved from previous work (Pita-Juárez et al., 2018)
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