1,722,835 research outputs found
New Perspectives in Network Studies: A Multidisciplinary Approach
No full textIn line with the multi-disciplinary nature of network research, this edited volume collects both empirical and conceptual contributions that nurture the debate on network research, specifically dealing with the topics of network performance and agency. The contributions draw on different literatures and epistemic approaches and address different levels of analysis, both from a static and a dynamic point of view. It will be of great interest to academics and students developing research in the field of network studies. It will also be of interest to scholars of operations management, organization studies, strategy, innovation, financial management and business history. © The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023
OP147 SKELETAL MUSCLE FUNCTION DEFICITS AND DYSMOBILITY SYNDROME: ARE THESE TOOLS BETTER CHARACTERIZING PATIENTS WITH FRAGILITY FRACTURES?
No full textIntroduction: Fragility fractures have a huge impact on the healthcare management of elderly patients. These
fractures are associated to impaired bone strength and functioning of skeletal muscle, and to characteristics
and circumstances of falls. It is well known that muscle weakness has a pivotal role in determining falls.
Recently have been proposed two new nosological entities, in order to identify functional limitation at an
early stage: the dysmobility syndrome and the skeletal muscle function deficits (SMFD). These conditions
are associated with an increased risk of fragility fractures. However, to the best of our knowledge, few studies
investigated the association between osteoporotic fractures and dysmobility syndrome or SMFD.
Purpose: The objective of this study was to evaluate the role of previous fragility fractures as risk factor for
dysmobility syndrome and/or SMFD in post-menopausal women.
Method: In this case–control study, we retrospectively examined data from the medical records of postmenopausal
women aged 50 or older. We divided the study population in two groups. The first group includes
women with a previous fragility fracture (cases) and the other group includes women without any previous
osteoporotic fracture (controls). We identified the subjects with dysmobility syndrome, dynapenic SMFD,
sarcopenic SMFD, and mixed SMFD, according to criteria proposed by Studenski et al. and Binkley et
al.respectively, in both groups. Data collected refer to a 6-month period.
Results: We retrieved data of 121 post-menopausal women, 77 (63.64 %) had already sustained a fragility
fracture at any site (cases). The risk for dysmobility syndrome was significantly higher (adjusted OR for age
and serum 25-OH vitamin D3 of 2.46) in the cases compared with the controls.
Discussion and conclusions: Early diagnosis of conditions limiting mobility, including dysmobility syndrome
and SMFD, in patients with a history of osteoporotic fracture could be useful to identify those who
have a higher risk of new fragility fractures
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