196,638 research outputs found
Morella Muñoz, mezzosorano (Venezuela)
No full textConcierto interpretado por Morella Muñoz acompañada en el piano de Nina De Iwanek. Morella nació en Caracas, Venezuela. Realizó sus estudios secundarios en el Liceo Andrés Bello de esa ciudad. Luego de realizar estudios de música en la Escuela José Angel Lamas, fue solista del Orfeón Universitario U.C.V. de Caracas y miembro del Orfeón Lamas en su ciudad natal. Siguió un curso de Historia de la Música y Estética Musical con Juan Bautista Plaza. Igualmente hizo estudios de canto con la profesora Lidya Butturini.
En este concierto interpretaron obras de Claude Debussy, Gabriel Fauré, Vaughan Williams, J. M. Capell, Christoph W. Gluck, Lodovico Rocca, Koscak Yamada, Koscak Yamada, Johannes Brahms, Hugo Wolf, Vicente Emilio Sojo, René Rojas, Inocencio Carreña y Antonio Estévez
Morella (985 m.) Conjunt
No full textBoExcursió del 18 al 21 de juny de 1981. Itinerari: Cim de Penyagolosa (1.813 m.) - Sant Joan de Penyagolosa - Vistabella del Maestrat (1.246 m.) - Vilafranca del Maestrat (1.125 m.) - Morella (985 m.) - Pista de Herbese
Morella (985 m.) Conjunt
No full textBoExcursi del 18 al 21 de juny de 1981. Itinerari: Cim de Penyagolosa (1.813 m.) - Sant Joan de Penyagolosa - Vistabella del Maestrat (1.246 m.) - Vilafranca del Maestrat (1.125 m.) - Morella (985 m.) - Pista de Herbese
Morella. El castell, als 1.070 m.
No full textBoExcursió del 18 al 21 de juny de 1981. Itinerari: Cim de Penyagolosa (1.813 m.) - Sant Joan de Penyagolosa - Vistabella del Maestrat (1.246 m.) - Vilafranca del Maestrat (1.125 m.) - Morella (985 m.) - Pista de Herbese
Su un cratere del Pittore di Meleagro dal Padule di Bientina
No full textThe bell krater, that I have tributed to Meleager Painter(first third of the fourth century B.C.), it served as cinerary in a tomb, according to custom well testified in the Western Greek World and Anhellenic Italy. The shape and the hierogamia of Dionysos and Ariadne depicted on the side A symbolize for the followers of Dionysos cult a life of bliss and a endless symposium after the death
Morella, a 985 m., vista des del sud
No full textBoExcursió del 18 al 21 de juny de 1981. Itinerari: Cim de Penyagolosa (1.813 m.) - Sant Joan de Penyagolosa - Vistabella del Maestrat (1.246 m.) - Vilafranca del Maestrat (1.125 m.) - Morella (985 m.) - Pista de Herbese
Turismo, territorio y medio ambiente en Morella. Del P.G.O.U. (1986) a la Agenda 21 local (2000)
No full textThe present work tries to analyze from the perspective of the geography of the tourism, this is assisting to the territorial and environmental actions, of what Morella forms he/she has gone configuring you as the tourist destination of more visited interior of the Country Valencia. From 1964 until the year 2000, first a group of public and private, cultured but relatively improvised initiatives, and from 1980 three strategic documents of territorial ordination (PGOU, 1986; PIRCT, 1996; PACA, 2000), they have gone sitting down the bases so that the tourism facilitates the active recovery of the cultural patrimony and energize the group of the municipal and regional economy. In that context, the mark Morella, a consolidated cultural tourist product, he/she needs to pass of the quantitative actions of adaptation and setting in tourist value to other qualitative ones presided over by the sostenibilidad. It is hour of assuming the challenge of the sustainable administration of the tourism, what requires to reconcile the natural and cultural conservation with the new economic and social perspectives that he/she opens the tourist function.El presente trabajo intenta analizar desde la perspectiva de la geografía del turismo, esto es atendiendo a las acciones territoriales y ambientales, de qué forma Morella ha ido configurándose como el destino turístico de interior más visitado del País Valenciano. Desde 1964 hasta el año 2000, primero un conjunto de iniciativas públicas y privadas, ilustradas pero relativamente improvisadas, y desde 1980 tres documentos estratégicos de ordenación territorial (PGOU, 1986; PIRCT, 1996; PACA, 2000), han ido sentando las bases para que el turismo posibilite la recuperación activa del patrimonio cultural y dinamice el conjunto de la economía del municipio y de la comarca. En ese contexto, la marca Morella, un producto turístico cultural consolidado, necesita pasar de las acciones cuantitativas de adecuación y puesta en valor turístico a otras cualitativas presididas por la sostenibilidad. Es hora de asumir el reto de la gestión sostenible del turismo, lo que requiere conciliar la conservación natural y cultural con las nuevas perspectivas económicas y sociales que abre la función turística
Morella. Detall
No full textBoExcursió del 18 al 21 de juny de 1981. Itinerari: Cim de Penyagolosa (1.813 m.) - Sant Joan de Penyagolosa - Vistabella del Maestrat (1.246 m.) - Vilafranca del Maestrat (1.125 m.) - Morella (985 m.) - Pista de Herbese
Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders
No full textHere we discuss the role of diverse environmental manipulations affecting cognition with special regard to psychiatric conditions. We present evidence supporting a direct causal correlation between the valence of the environmental stimulation and some psychopathological traits and how the environment influences brain structure and function with special regard to oxidative stress and mitochondrial activity.
Increasing experimental evidence supports a role for mitochondrial dysfunctions in neuropsychiatric disorders. Brain mitochondria are considered crucial mediators of allostasis, that is the capability to adapt to stress via a complex interaction between the autonomic, metabolic, and immune systems to maintain cellular homeostasis. In this process, mitochondria act as highly dynamic integrators by sensing and transducing stressors into adaptation mechanisms via metabolic stress mediators, such as glucocorticoids and catecholamines. Alterations in cellular homeostasis induced by chronic stress are thought to predispose to disease by triggering the so-called “mitochondrial allostatic load”. This process is characterized by functional and structural changes of the mitochondria, ultimately leading to oxidative stress, inflammation, mitochondrial DNA damage and apoptosis.
In this review we discuss the role of diverse environmental manipulations to affect cognition with special regard to psychiatric conditions. How the environment influences brain structure and function, and the interactions between rearing conditions, oxidative stress and mitochondrial activity are fundamental questions that are still poorly understood.
As will be discussed, increasing experimental evidence supports a role for mitochondrial dysfunctions in neuropsychiatric disorders. Brain mitochondria are considered crucial mediators of allostasis, that is the capability to adapt to stress via a complex interaction between the autonomic, metabolic, and immune systems to maintain cellular homeostasis. In this process, mitochondria act as highly dynamic integrators by sensing and transducing stressors into adaptation mechanisms via metabolic stress mediators, such as glucocorticoids and catecholamines. Alterations in cellular homeostasis induced by chronic stress are thought to predispose to disease by triggering the so-called “mitochondrial allostatic load”. This process is characterized by functional and structural changes of the mitochondria, ultimately leading to oxidative stress, inflammation, mitochondrial DNA damage and apoptosis.
The brain requires considerable mitochondrial reserve not only to sustain basal neuronal needs but a also to provide increasing energy demands during stress. Consistently with these high energetic requirements, it is reasonable to hypothesise that the brain is particularly vulnerable to mitochondrial defects. Thus, even subtle metabolic alterations might have a substantial impact on cognitive functions.
Over the last decade, several experimental evidence supported the hypothesis that a suboptimal mitochondrial function, which could be of genetic origin or acquired following adverse life events, is a key vulnerability factor for stress-related psychopathologies. Chronic psychological stress is a major promoter of anxiety as well as of oxidative damage, as shown in several studies. Recent evidence from mouse models harbouring mutations in mitochondrial genes demonstrated the role of mitochondria in modulating the response to acute psychological stress. However, it has yet to be determined whether mitochondrial dysfunctions are the cause or the consequence of anxiety.
In this review, we discuss how adverse psychosocial environments can impact mitochondrial bioenergetics at the molecular level and we gather evidence from several studies linking energy metabolism and stress resilience/vulnerability.
Moreover, we review recent findings supporting that metabolic dysfunction can underlie deficits in complex social behaviours. As will be discussed, aberrations in mitochondrial functionality have been found in the nucleus accumbens of highly anxious mice and mediate low social competitiveness. In addition, alterations in sociability can be reversed by enhancing mitochondrial functions. Recent evidence also demonstrated that a specific mutation in mitochondrial DNA, previously linked to autism spectrum disorder, produces autistic endophenotypes in mice by altering respiration chain and reactive oxygen species (ROS) production.
Finally, we discuss a “Negative Enrichment” model that can explain some of the psychopathological conditions relevant to humans. Evidence of a direct causal correlation of valence of environmental stimulation and psychopathological traits will be presented, and possible molecular mechanisms that focus on oxidative stress.
Collectively, the findings described here have been achieved with a wide set of behavioural and cognitive tasks with translational validity. Thus, they will be useful for future work aimed to elucidate the fine metabolic alterations in psychopathologies and devise novel approaches targeting mitochondria to alleviate these conditions
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