322,957 research outputs found
Non-haemorrhagic adverse reactions of oral anticoagulant therapy
No full textOral anticoagulants are extensively used in everyday medical practice, especially for the prophylaxis of deep vein thrombosis and pulmonary thromboembolism. Bleeding is the major risk of such therapy. Although infrequent, however, non-haemorrhagic complications may also play a considerable role. The purpose of this paper is briefly to review the most important non-haemorrhagic adverse reactions and their clinical signs. Moreover, the pathogenetic hypotheses, the relationships with protein C and S levels, and the possibility of prevention and treatment are also discussed
Erminia Al Campo : Trattenimento Musicale ; Rappresentato Ne' Giorni Carnevaleschi Per Commando Del A. S. Del Duca Di Giuliers Prencipe Ellettorale Palatino. Et alla medesima Altezza consacrato
No full textPosto in Musica dal Sign D. Sebastiano Moratelli. [Text: Giorgio Maria Rapparini
Low Sensitivity to Endogenous Activated Protein C in Protein S Deficient Subjects Reflects a Reduction in the Thrombotic Risk
No full textLow Sensitivity to Endogenous Activated Protein C in Protein S Deficient Subjects Reflects a Reduction in the Thrombotic Risk, and not to an assay problem
Separation of monophyletic groups into distinct genera should consider phenotypic discontinuities: the case of Lasiurini (Chiroptera: Vespertilionidae)
No full textNovaes, Roberto Leonan M., Garbino, Guilherme S. T., Cláudio, Vinícius C., Moratelli, Ricardo (2018): Separation of monophyletic groups into distinct genera should consider phenotypic discontinuities: the case of Lasiurini (Chiroptera: Vespertilionidae). Zootaxa 4379 (3): 439-440, DOI: https://doi.org/10.11646/zootaxa.4379.3.
Resistance to activated protein C and low levels of protein S activity in nine thrombophilic families: a correct diagnosis.
No full textIn order to define the thrombophilic conditions related to activated protein C resistance (APC-R) and protein S (PS) deficiency and to detect the possible combination of these defects, we studied nine unrelated patients selected because of low anticoagulant response to APC and reduced PS activity with at least one first degree relative having the same coagulation feature. The mean APC ratio was 0.64 (normal values > 0.80) and range 0.35-0.80. Three of the patients were heterozygous and two were homozygous for the Leiden mutation (FVR506Q); in the remaining four there was no mutation. The mean PS activity was 41.6% and range 32-54 (normal 65-150%). Five of the patients had low PS activity despite normal total and free antigenic levels, and normal activity when measured at higher plasma dilution; these were carrying at least one gene for the Leiden mutation. In the remaining four patients the crossed-immunoelectrophoresis and the Western-blotting analysis showed a type I PS deficiency confirmed by the familial restriction fragment length polymorphism analysis. Thus, four families were diagnosed with the type I PS defect and five with congenital APC-R. No combined PS/FV Leiden or type II PS defect was found. The only defect found was in the anticoagulant PC pathway. We therefore designed a procedure to diagnose thrombophilic conditions related to this pathway. This study indicates that a specific methodological approach must be used to accurately characterize APC-R and PS deficiency and that care is necessary to avoid the possibility of misdiagnosis
Myotis lavali Moratelli et al. 2011
No full text405. LaVal's Myotis Myotis lavali French: Murin de LaVal / German: LaVal-Mausohr / Spanish: Ratonero de LaVal Taxonomy. Myotis lavali Moratelli et al, 2011, “6.km S of Exu (7°30'S, 30°43'W), Pernambuco State, Brazil, 523 m above sea level.” Subgenus Pizonyx; albescens species group. See M. nigricans. Monotypic. Distribution. From NE Brazil to Paraguay and NW Argentina. Descriptive notes. Head-body c.41 50 mm, tail 31-42 mm, ear 11-14 mm, hindfoot 5-8 mm, forearm 31: 5-37 mm; weight 3-7 g. Fur is long and silky (dorsal fur ¢. 7 mm; ventral fur ¢. 6 mm). Dorsal hairs are strongly bicolored, with medium brown bases (two-thirds the total length) and light-brown tips; ventral hairs are strongly bicolored, with dark brown bases (two-thirds the total length) and cinnamon buff tips. Specimens from Atlantic Forest can have darker dorsal fur and less contrast between bases and tips. Ears are short, extending forward halfway from eye to nostril. Antitragal notch is barely evident. Tragusis pointed, slightly curving outward above and convex below, with small (length 7-9 mm) triangular lobule at outer base. Plagiopatagium is attached to toes by a broad band of membrane. Fringe of hairs along trailing edge of uropatagium is absent, although some hairs can be present in a few specimens. Membranes are mummy brown. Skull is small to moderate in size (greatest length of skull 13-2-15- 2 mm), with long and upwardly oriented rostrum; postorbital constriction is narrow; forehead slopes steeply relative to skull; supraoccipital region is rounded; occipital projects beyond posterior limit of occipital condyles; sagittal and lambdoid crests are generally present and low; and P? is generally in tooth row. Habitat. Brazilian Caatinga and Cerrado and Paraguayan Alto Chaco ecoregions, predominantly with semiarid and savanna formations, with peripheral records in seasonal semideciduous forests in adjacent Atlantic Forest at elevations of 15-900 m (apparently more frequent at ¢. 350-550 m. Food and Feeding. [L.aVal’s Myotis forages in open areas and over water, capturing prey in flight. Diets include various insects, particularly Coleoptera, Hymenoptera, and Lepidoptera. Breeding. L.aVal’s Myotis from Brazilian Caatinga breeds year-round, with no peaks of pregnancy or lactation in rainy seasons. Activity patterns. [.aVal’s Myotis emerges just before sunset. In Brazilian Caatinga,its activity 1s concentrated in the first five hours after sunset, and it roosted in horizontal crevices in sandstone rock, small cave in a sandstone plateau with xeric shrub vegetation, and rooftops of abandoned human dwelling. Wing morphology is typical of aerial insectivore that uses cluttered spaces. Movements, Home range and Social organization. In Brazilian Caatinga, LLaVal’s Myotis formed colonies of 16-20 individuals. Status and Conservation. Classified as Least Concern on The IUCN Red List. L.aVal’s Myotis is widespread and presumably has a large population. Bibliography. Barquez et al. (2017), Moratelli & Wilson (2013), Moratelli, Peracchi, Dias & Oliveira (2011), Solari (2017), Willig (1985a, 1985c).Published as part of Don E. Wilson & Russell A. Mittermeier, 2019, Vespertilionidae, pp. 716-981 in Handbook of the Mammals of the World – Volume 9 Bats, Barcelona :Lynx Edicions on page 942, DOI: 10.5281/zenodo.639775
Bassi livelli di Proteina S e Resistenza alla Proteina C attivata in dieci famiglie italiane.
No full textRicerche metodologiche sul dosaggio del cofattore Ristocetinico per la diagnosi di morbo di von Willebrand.
No full textDifferent anticoagulant response to activated protein C (APC test) and to Agkistrodon Contortix venom (ACV test) in a family with FV-R506Q substitution
No full textTo identify the defect(s) responsible for the thrombotic condition affecting a 55-year-old male and his family, we have utilized a new methodological approach (ProC Global®, Istituto Behring, Milan, Italy) to screen the global anticoagulant activity of the protein C pathway, a defect that accounts for the majority of inherited thrombophilias. The test is based on the activation of endogenous protein C in plasma by Protac®, derived from Agkistrodon contortix snake venom (ACV test). Nineteen members of the family were investigated, 11 showed low responsiveness to ACV (normalized ACV ratios < 0.66; normal > 1. 12); in these individuals specific assays of protein C (PC) and protein S (PS) levels and normalized activated protein C ratios (n-APC-r) were performed. A second test evaluating response to APC, using the classic commercial APC test (n-APC-r 1), detected only 10 subjects with abnormal responses : the propositus and two members of the family with n-APC-r 1 values < 0.54, indicating the homozygous state for the R506Q factor V gene mutation, and seven with values ranging 0.69-0.83, consistent with the heterozygous condition (normal > 0.85). Although only ten subjects presented with low n-APC-r 1 values, DNA analysis, in agreement with the ACV test, detected 11 individual with factor V-R506Q substitution (two homozygotes and nine heterozygotes). Thus the classical APC test failed to identify the APC resistance phenotype in two heterozygous subjects whose values were clearly normal (1.05) in the first case and homozygous (0.53) in the second. The ACV test, however, and the modified APC test with test plasma 1/5 diluted in factor V-deficient plasma (n-APC-r 2) completely matched the DNA analysis. A phenotype/genotype correlation was observed in dilutions higher than 1/3 test plasma factor V-deficient plasma. The presence of unknown mechanisms that influence plasma response to exogenous preformed APC (normal at high factor V-deficient plasma dilutions) but not endogenous ACV activated PC was suspected. The suspected low levels of proteins C and S found in several R506Q members of the family were excluded by reassaying the anticoagulant activities at higher plasma dilution ; this supports the known influence of factor V Leiden on functional PC and PS clotting activity. We conclude that the ACV test is appropriate to evaluate the APC resistance condition, but for a firm diagnosis DNA analysis together with the modified APC test are strongly advised even in the presence of unquestionable APC-r values
Low folate levels and thermolabile MTHFR as primary determinant of mild Hyperhomocysteinemia in normal and thromboembolic subjects.
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