1,721,329 research outputs found
Spontaneous ATM gene reversion in A-T iPSC to produce an isogenic cell line
No full textA spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide SNP analysis confirmed a match to source T-cells and also to a distinct, non-reverted iPSC line from the same subject. Rearranged T-cell receptor sequences predict that the iPSC culture originated as several independently reprogrammed cells that resolved into a single major clone, suggesting that gene correction likely occurred early in the reprogramming process. Gene expression analysis comparing ATM-/- iPSC lines to unrelated ATM+/- cells identifies a large number of differences but comparing only the isogenic pair of A-T iPSC lines reveals that the primary pathway affected by loss of ATM is a diminished expression of p53-related mRNAs. Gene reversion in culture, while likely a rare event, provided a novel, reverted cell line for studying ATM function.Peer reviewe
IASSIST / DCN Data Curation Workshop
Full text linkWorkshop at the 2018 IASSIST Annual Conference.“Launching the Data curation Network: A cross-institutional staffing model for curating research data” funded 2018-2021 by the Alfred P. Sloan Foundation grant G-2018-10072.Moore, Jennifer; Blake, Mara; Sedlins, Mara; Kozlowski, Wendy. (2018). IASSIST / DCN Data Curation Workshop. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/208683
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Human Subjects Data Essentials Data Curation Primer
No full textAlfred P Sloan Foundation and the Institute of Museum and Library Services RE-85-18-0040-18Darragh, Jen; Hofelich Mohr, Alicia; Hunt, Shanda; Woodbrook, Rachel; Fearon, Dave; Moore, Jennifer; Hadley, Hannah. (2020). Human Subjects Data Essentials Data Curation Primer. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/216579
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
GeoDatabase (.gdb) Data Curation Primer
No full textThis work was created as part of the Data Curation Network “Specialized Data Curation” Workshop #1 co-located with the Digital Library Federation (DLF) Forum 2018 in Las Vegas, Nevada on October 17-18, 2018.The geodatabase is a container for geospatial datasets that can also provide relational functionality between the files. Although the term geodatabase can be used more widely, this primer describes the ArcGIS geodatabase designed by Esri.Institute of Museum and Library Services RE-85-18-0040-18.Battista, Andrew; Brittnacher, Tom; Garrett, Zenobie; Moore, Jennifer; Pirmann, Carrie. (2019). GeoDatabase (.gdb) Data Curation Primer. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/202823
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