6,144 research outputs found
Delayed-release oral suspension of omeprazole for the treatment of erosive esophagitis and gastroesophageal reflux disease in pediatric patients: a review
No full textAlice Monzani, Giuseppina Oderda1Department of Pediatrics, Università del Piemonte Orientale, Novara, ItalyAbstract: Omeprazole is a proton-pump inhibitor indicated for gastroesophageal reflux disease and erosive esophagitis treatment in children. The aim of this review was to evaluate the efficacy of delayed-release oral suspension of omeprazole in childhood esophagitis, in terms of symptom relief, reduction in reflux index and/or intragastric acidity, and endoscopic and/or histological healing. We systematically searched PubMed, Cochrane and EMBASE (1990 to 2009) and identified 59 potentially relevant articles, but only 12 articles were suitable to be included in our analysis. All the studies evaluated symptom relief and reported a median relief rate of 80.4% (range 35%–100%). Five studies reported a significant reduction of the esophageal reflux index within normal limits (<7%) in all children, and 4 studies a significant reduction of intra-gastric acidity. The endoscopic healing rate, reported by 9 studies, was 84% after 8-week treatment and 95% after 12-week treatment, the latter being significantly higher than the histological healing rate (49%). In conclusion, omeprazole given at a dose ranging from 0.3 to 3.5 mg/kg once daily (median 1 mg/kg once daily) for at least 12 weeks is highly effective in childhood esophagitis.Keywords: proton pump inhibitors, children, ranitidine, H2-blocker
Determinants of renal function in preterm newborns
No full textBackground: Little is known about potential endogenous biomarkers of renal function other than serum creatinine (sCr). Aims: to evaluate cystatine C (CysC) and beta-trace protein (BTP) levels in preterm newborns and to assess the impact of kidney-detrimental factors on kidney function. Methods: newborns with GA28wks (p=0.016). At T0, sCr was negatively correlated with GA (R= -0.315, p=0.009), whereas CysC and BTP were not influenced by GA. At T36, newborns with GA 28 wks had lower sCr, BTP and higher urea levels (p=0.007, p=0.005 and p=0.029, respectively). At T36 eGFR values calculated by the four formulas using only CysC were not different in newborns with GA 28 and >28wks. eGFR values estimated by other formulas were higher in subjects born at a
lower GA. We found a direct correlation between the post-natal score and eGFR estimated according to the sCr-based formulas by Schwartz2009 (R=0.345, p=0.027) and Brion (R=0.312, p=0.044), not persisting after adjustment for urea levels at T36 and GA. No correlations were found between the scores and eGFR according to the other formulas. Conclusions: eGFR formulas using CysC are not influenced by GA. Post-natal score shows a direct correlation with eGFR according to sCr-based formulas, which does not persist after adjustment for GA and urea levels, showing that the underlying confounder may be the nutritional status of preterm newborns, as suggested by the higher urea levels in newborn with GA 28wks at T36
Alice and Cliff Donahue
No full textPhotograph - Friends of Alice B. and William Clifford Donahue, Athabasca, Alberta. Seated, left to right: Cliff Donahue, Joe Mikkelsen, Beryl Mikkelsen, and Marge Logan. Standing, left to right: Don Logan, Alice B. Donahue, Aaron Jones, Lorene Jones, and Beatrice Par
Alice B. Donahue - 09
No full textPhotograph - Alice B. Donahue at flooded campsite on the Athabasca River, Athabasca, Albert
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