9,713 research outputs found
Barbara James
No full textDate:1943Barbara was born in Holdredge, Nebraska in the United States of America in 1943. In 1960 she arrived in Darwin working in a variety of occupations such as a journalist, historian, author, activist, advocate and editor. Barbara wrote 13 books including "No Man's Land" which explored the contributions of women in the Northern Territory. She also received a number of awards including 2001 NT Heritage Award, the 2000 NT Literary Essay Awards and the Chief Minister's Women's Achievement Award in 1999.JournalistHistorianAuthorActivistEditorAmerica
Telethon GGP19067-2019 - "Alla ricerca di nuovi bersagli terapeutici per contrastare l’ipomielinizzazione nell’AGC1 deficiency: uno studio multidisciplinare sui precursori delle cellule cerebrali".
No full textLa deficienza di AGC1 è una malattia genetica ultra-rara che porta a una grave encefalopatia infantile, causata da mutazioni del gene SLC25A12 che codifica per l’isoforma 1 del trasportatore mitocondriale di aspartato/glutammato (AGC1). I pazienti mostrano arresto psicomotorio, convulsioni, atrofia cerebrale e una diffusa ipomielinizzazione con marcata riduzione di N-Acetil-Aspartato (NAA), un precursore cruciale per la formazione di mielina nel cervello. Al momento non è disponibile alcuna cura e i meccanismi molecolari della malattia non sono ancora chiari. Abbiamo precedentemente dimostrato il ruolo di AGC1 nella regolazione della proliferazione dei precursori di neuroni e oligodendrociti, le principali cellule cerebrali coinvolte nella mielinizzazione e nella sintesi di NAA, spiegando i sintomi clinici dei pazienti. Il progetto ha lo scopo di chiarire i meccanismi che influenzano la disfunzione della mielinizzazione in nuovi e più appropriati modelli cellulari della malattia derivati da topi transgenici o dal differenziamento di cellule staminali indotte di pazienti. In questi modelli, identificheremo i meccanismi trascrizionali ed epigenetici, e le vie biochimiche cellulari alterate, usando sia approcci di biologia molecolare e computazionale, che bioenergetici e metabolomici. Questo approccio multidisciplinare aiuterà a svelare i meccanismi che portano all’alterato processo di mielinizzazione nella deficienza di AGC1, identificando così potenziali target per contrastare l'ipomielinizzazione e per sviluppare terapie più appropriate e personalizzate per i pazienti. Inoltre, considerando che questa patologia condivide molte caratteristiche cliniche con altre rare malattie neurologiche, inclusa l'ipomielinizzazione, questi target potrebbero essere testati anche in altre patologie simili
Guest editor della special Issue "Microglia in neurodegeneration" nella sezione "Molecular Biology" della rivista Biomolecules
No full textBiomolecules è una rivista open-access peer-reviewed sulle sostanze biogeniche (incluse ma non limitate a proteine, acidi nucleici, polisaccaridi, membrane, lipidi, metaboliti, ecc.). Viene pubblicata mensilmente online da MDPI
Barbara Ras - Sowell Conference 2017
No full textBarbara Ras, San Antonio, Poet, author of "Bite Every Sorrow" and "The Last Skin
I Sacri Monti nella cultura artistica (secc. 16-17)
No full textSono presentati i principali momenti della 'fortuna critica' della civiltà artistica dei Sacri Monti tra Lombardia e Piemonte negli studi del Novecent
Exclusive interview with author Barbara Kingsolver
No full textExclusive interview with author Barbara Kingsolver for her 2018 novel *Unsheltered
Dataset for publication: Post‐war architecture and urban planning as means of reinventing Opole’s past and identity
No full textThe collection includes files related to the publication: Barbara Szczepańska, Post‐War Architecture and Urban Planning as Means of Reinventing Opole’s Past and Identity, „Urban Planning”, Vol 8, No 1 (2023): Bombed Cities: Legacies of Post-War Planning on the Contemporary Urban and Social Fabric, pp. 266-278, https://doi.org/10.17645/up.v8i1.6079. The collection includes figures used in the publication:Opole_plan A plan of Opole, with areas of Ostrówek (left), Market Square (center) and Central Square (right) highlighted in red. Originally published in: "Guidebook to the city of Opole" ("Przewodnik po mieście Opolu", Opole: Księgarnia Opolska, 1948, https://polona.pl/preview/2f383a4a-5e9e-444d-9e94-366b8ac8610d). Author: Z. Streer. Licence: CC0Opole_Monument to the Opole Silesian Fighters for Freedom A photograph depicting Monument to the Opole Silesian Fighters for Freedom (Pomnik Bojownikom o Wolność Śląska Opolskiego) in Opole. Author: Barbara Szczepańska. Licence: CC0Opole_monument of Kazimierz I Opolczyk A photograph depicting the monument of Kazimierz I Opolczyk in the Market Square in Opole. Author: Barbara Szczepańska. Licence: CC0Opole_Market Square_eastern frontage A photograph depicting eastern frontage of the Market Square in Opole. Author: Barbara Szczepańska. Licence: CC0Opole_Market Square_eastern frontage_before 1945 A photograph depicting eastern frontage of the Market Square in Opole before 1945. Originally published on Wikimedia Commons: https://commons.wikimedia.org/wiki/File:Market_Square_in_Opole,_eastern_frontage.jpg. Author: unknown. Licence: CC0Opole_monument of Frederick the Great A photograph depicting monument of Frederick the Great in Opole, before 1945. Originally published on Wikimedia Commons: https://commons.wikimedia.org/wiki/File:Opole_Oppeln_Denkmal_Friedrich_der_Große.jpg. Author: unknown. Licence: CC0</ul
'A date with Barbara': paracosms of the self in biographies of Barbara Newhall Follett
No full textIn 1927, 13-year-old Barbara Newhall Follett published her first book, the critically acclaimed novel, The House Without Windows and Eepersip's Life There.
Twelve years later, on December 7, 1939, 25-year-old Barbara quarrelled with her husband and left her apartment in Boston with $30 in her pocket, and a notebook. She was never seen again.
The House Without Windows is set in a paracosm (Farksolia) she invented, and ends with the metamorphosis of the titular character into a 'fairy-a wood nymph … invisible for ever to all mortals, save those few who have minds to believe, eyes to see'.
In Barbara's (auto)biography, The Unconscious Autobiography of a Child Genius (1966), written by Harold Grier McCurdy 'in collaboration with Helen Follett' (Barbara's mother), the authors wonder: 'Can we be far wrong in substituting Barbara's name for Eepersip's in the closing scenes of [House Without Windows]?
In this paper, I grapple with the formal and ethical challenges of writing about Barbara Newhall Follett, and the ways her family and others have approached the problem of writing her unresolved life story: a child raised and educated in solitude, a celebrated 'natural' child author, a young woman whose disappearance remains unsolved. The paper will explore the ways in which adults write the stories of children's lives, as nostalgia and fable, as fairytale and paracosmic narrative, and the ways in which Barbara's biographers have, consciously and unconsciously, created biographical concordances, or paracosms of the self, in seeking to make meaning of her life's story
Barbara Ehrenreich: Blood Rites: A New Evolutionary Perspective on Violence
No full textBarbara Ehrenreich, author, social critic and political essayist, discusses the emotional and social aspects of warfare and violence.
Barbara Ehrenreich is an American author and political activist who describes herself as a myth buster by trade” and has been called a veteran muckraker by The New Yorker.During the 1980s and early 1990s she was a prominent figure in the Democratic Socialists of America. She is a widely read and award-winning columnist and essayist, and author of 21 books. Ehrenreich is perhaps best known for her 2001 book Nickel and Dimed: On (Not) Getting By in America
Tra latino e volgare: il linguaggio giuridico in età medioevale e moderna
No full textLe lingue del diritto in Europa tra medioevo ed età moderna riflettono il complesso sistema delle fonti del diritto vigente: il latino e' la lingua dotta dei testi romani e dei giuristi di scuola, mentre l'uso delle lingue nazionali si diffonde progressivamente nelle leggi e nella prassi
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