1,721,587 research outputs found
Potential useful prognostic parameters after transcatheter aortic valve implantation: editorial
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Does non-alcoholic fatty liver disease (NAFLD) increase cardiovascular risk?
No full textNon alcoholic fatty liver disease (NAFLD) is defined as fat accumulation exceeding 5% to 10% by the weight of the liver, in the absence of other causes of steatosis. NAFLD is strongly associated with metabolic diseases, such as metabolic syndrome. At present, insulin resistance, elevated concentrations of free fatty acids and oxidants, and an imbalance between different cytokines have been identified as the common pathophysiological elements underlying both NAFLD and metabolic syndrome. Emerging evidence also considers NAFLD as the hepatic manifestation of metabolic syndrome and supports a possible direct role of fat liver in cardiovascular risk assessment. Further investigations are needed to better understand the role of NAFLD, as an independent active factor in metabolic syndrome and associated cardiovascular disease
Update on the evidence of statin treatment to reduce plaque vulnerability
No full textIschemic stroke represents one of the major causes of mortality and disability in the adult population in both developed and developing nations. Considering these epidemiological issues, the improvement of preventive therapeutic strategies has been recently targeted as a pivotal research field for scientific community. On the basis of the results from several large clinical studies and met analyses, some Task forces of researchers from recognized Scientific Societies have recently produced some consensus Guide lines, recommending the use of statins as a key pharmacologic approach in stroke prevention. In the present narrative review, we will update evidence on safety and efficacy of statins to prevent ischemic cerebral stroke
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