982 research outputs found
Erratum: Allen, G.R., Erdmann, M.V. & Purtiwi, P.D. (2017): Author Purtiwi, P.D. is spelled Pertiwi, P.D.
No full textAllen, G.R., Erdmann, M.V. & Purtiwi, P.D. (2017) Descriptions of four new species of damselfishes (Pomacentridae) in the Pomacentrus philippinus complex from the tropical western Pacific Ocean. Journal of the Ocean Science Foundation, 25, 47–76.
corrected spelling of third author’s name to:
Allen, G.R., Erdmann, M.V. & Pertiwi, P.D. (2017) Descriptions of four new species of damselfishes
(Pomacentridae) in the Pomacentrus philippinus complex from the tropical western Pacific Ocean. Journal of the Ocean Science Foundation, 25, 47–76
The philosophy poetry of G.R. Derzhavin: the contrast of life and death
No full textThis article is devoted to the eshatological philosophical concept of the G.R. Derzhavins’ poetry. The author describes the presentation of the theme of death and its artistic transformation in the works of the poet as the reception of the Orthodox tradition, a kind of the cultural memory
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Spectral properties of Andreev reflection from quantum turbulence in 3He-B: What do they tell about turbulent fluctuations?
No full textOne of the experimental techniques developed to measure quantum turbulence at low temperatures in 3He-B utilizes the Andreev reflection of thermal quasiparticle excitations from quantized vortices and vortex structures. We present the results of theoretical, numerical, and experimental study of Andreev scattering from quantum turbulence in 3He-B. We analyze the spectral properties of the Andreev reflection and compare these with the spectral properties of superfluid turbulence, and discuss the physical mechanisms responsible for the scaling of spectral densities. Finally, we discuss the relation between our findings and related observables in ordinary turbulence
Discovering the genetic cause of Mendelian disorders in the age of genomics: the evolving capability of next-generation DNA sequencing
No full textThe research presented in this thesis identifies the genetic cause of a diverse range of Mendelian disorders using next generation sequencing. This work reflects the extremely rapid development of NGS, beginning with target gene panel sequencing in a research setting (Chapters 2 and 3) and only 4 years later progressing to our evaluation of diagnostic yield if whole-exome sequencing is implemented in the clinic and when using whole-genome sequencing for our research (Chapters 7 and 8). These discoveries show the evolving capability of NGS to uncover the genetic cause of Mendelian disorders and the revolution upon healthcare occurring as a result of its application. In Part I we utilize NGS to discover genetic variants in patients with rare phenotypes for which no genetic cause is known. In Chapter 2 and Chapter 3 we use a targeted gene panel sequencing approach to identify causal variants by including known genes involved in disease etiology and candidate genes that could play a role in development of disease. In Chapter 4 we move to a more comprehensive approach by utilizing WES to analyze the coding regions of all known protein coding genes and eventually establish a genetic diagnose for two brothers with Mohr syndrome. In Part II we focus on rare metabolic diseases patients born of consanguineous parents and use regions of homozygosity to narrow our genetic search space for causal genes. We use targeted gene panel sequencing to evaluate all genes within the regions of homozygosity (Chapter 5) or identify candidate genes in those regions to Sanger sequence (Chapter 6). Finally, in Part III we progress to the clinical utility of NGS by performing a study analyzing the diagnostic yield of trio-WES and concurrently evaluate cost savings if this technology was implemented early (Chapter 7). In Chapter 8 we discuss the state-of-art of NGS and its implications for the patient, the clinic, and society. The expanding scope and use of NGS will enable more patients to obtain faster diagnoses and remodel the healthcare system, though there are still challenges to address. Finally, the ability to sequence our own genomes will impact individuals with the possibility of “personal genomes”, including my own, and what this may mean for society
Corrigendum: EEG beta suppression and low gamma modulation are different elements of human upright walking
No full textA corrigendum on EEG beta suppression and low gamma modulationare different elements of human upright walking by Seeber,M.,Scherer,R.,Wagner,J.,Solis-Escalante,T.,andMüller-Putz,G.R.(2014)Front.Hum. Neurosci.8:485.doi:10.3389/fnhum.2014.00485Biomechanical EngineeringMechanical, Maritime and Materials Engineerin
Refinement of solutions to the linear complimentarity problem
No full textNash equilibrium;game theaory;matrices
High-performance, Cost-effective 3D Stacked Wide-Operand Adders
No full textThrough-Silicon Vias (TSV) based 3D Stacked IC (3D-SIC) technology introduces new design opportunities for wide operand width addition units. Different from state of the art direct folding proposals we introduce two cost-effective 3D Stacked Hybrid Adders with identical tier structure, which potentially makes the manufacturing of hardware wide-operand fast adders a reality. An N-bitadder implemented on a K identical tier stacked IC performs in parallel two N=K-bit additions on each tier according to the anticipated computation principle. Inter-tier carry signals performing the appropriate sum selection are propagated by TSVs. The practical implications of direct folding and of our hybrid carry-select/prefix approaches are evaluated by a thorough case study on 65nm CMOS 3D adder implementations, for operand sizes up to 4096 bits and 16 tiers. Our simulations indicate that in almost all configurations at least one of the two proposed 3D stacked hybrid approaches is faster than the fastest 3D folding approach. When considering an appropriate metric for 3D designs, i.e., the delay-footprint-heterogeneity product, the hybrid adders substantially outperform the folding counterparts by a factor in-between 1:67 and 23:95.Accepted Author ManuscriptComputer Engineerin
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