162 research outputs found
Letter discussing a contract with Robertson Topp
No full textThis letter is discussing the contract between Robertson Topp and the author, M.I. Harrington
Confirmation of payments made by Robertson Topp
No full textThis note provides confirmation that Robertson Topp has paid in full for work done on the Gayoso House. It is unclear who the author of this note is
Edyta Stein w pamięci Wrocławia
No full textThe article seeks to explore the role of Edith Stein’s memory in creating the contemporary identity of the city of Wrocław. The author distinguishes between two forms of this memory, that is to say remembrance and symbolic places (lieux de mémoire). The places of remembrance of Edith Stein, who was born in Breslau, are connected with her biography and the time she spend in this city. The symbolic places of the memory of Edith Stein represent the values of her life (such as the European Peace Cross, meticulously analysed by the author). Both forms of memory variously transformed the space of the city in significant landscape
Estimate made by Robert Fletcher
No full textThis note provides details on an estimate made by Robert Fletcher and an account of what the author had already paid to W.B. Greenlaw. The author and date of this note are unknown. An educated guess could be that the author is Roberton Topp
Letter regarding claims to recover back taxes on Cotton
No full textScanned and Uploaded by Will Clinton '19.In this letter, the author (name unreadable) is inquiring whether there is interest from Robertson Topp to recover back taxes paid to the government during the trade of Cotton
Clinical Application of Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Prostate Cancer
No full textApproximately a quarter of men with metastatic castrate resistant prostate cancer (mCRPC) have alterations in homologous recombination repair (HRR). These patients exhibit enhanced sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. Leveraging the synthetic lethality between PARP inhibition and HRR deficiency, studies have established marked clinical benefit and a survival advantage from PARP inhibitors (PARPi) in mCRPC, most notably in cancers with BRCA1/2 alterations. The role of PARPi is evolving beyond patients with HRR alterations, with studies increasingly focused on exploiting synergistic effects from combination therapeutics. Strategies combining PARP inhibitors with androgen receptor pathway inhibitors, radiation, radioligand therapy, chemotherapy and immunotherapy demonstrate potential additional benefits in mCRPC and these approaches are rapidly moving into the metastatic hormone sensitive treatment paradigm. In this review we summarise the development and expanding role of PARPi in prostate cancer including biomarkers of response, the relationship between the androgen receptor and PARP, evidence for combination therapeutics and the future directions of PARPi in precision medicine for prostate cancer
Edith Stein in the Memory of the City of Wrocław
No full textThe article seeks to explore the role of Edith Stein’s memory in creating the contemporary identity of the city of Wrocław. The author distinguishes between two forms of this memory, that is to say remembrance and symbolic places (lieux de mémoire). The places of remembrance of Edith Stein, who was born in Breslau, are connected with her biography and the time she spend in this city. The symbolic places of the memory of Edith Stein represent the values of her life (such as the European Peace Cross, meticulously analysed by the author). Both forms of memory variously transformed the space of the city in significant landscape
Vibration analysis of a swept wing
No full textThesis (M.S.)-- University of Wichita, College of Engineering, Dept. of Aeronautical EngineeringThe purpose of solving the problem in this thesis is not only to provide an evaluation of the accuracy of the “elastic axis” approach, but also to review the methods to improve the accuracy of higher mode solutions. It is not the intention of the author to imply that this is the best or only approach in this instance; there are, of course, many others.
The area of the problem is restricted to that portion directly involved in the vibration analysis in order that the paper would not become too voluminous and the methods clouded by insignificant details of structural analysis.Introduction -- The lagranges equations of motion -- Calculation of influence coefficients by matrices -- Analysis -- Conclusions -- Bibliography -- Appendi
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