650 research outputs found
Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study
No full textWe report on the early clinical outcomes of a prospective series of early breast cancer (EBC) patients treated with ultra-hypofractionated post-operative whole-breast irradiation (WBI) after breast-conserving surgery (BCS) and axillary management. Primary endpoints were patient’s compliance and acute toxicity. Secondary endpoints included physician-rated cosmesis and ipsilateral breast tumour recurrence (IBTR). Acute toxicity was evaluated at the end of WBI, 3 weeks and 6 months thereafter, according to the Common Terminology Criteria for Adverse Events (v. 5.0). Patients were treated between September 2021 and May 2022. The treatment schedule for WBI consisted of either 26 Gy in 5 fractions over one week (standard approach) or 28.5 Gy in 5 fractions over 5 weeks (reserved to elders). Inverse planned intensity-modulated radiation therapy (IMRT) was used employing a static technique. A total of 70 patients were treated. Fifty-nine were treated with the 26 Gy/5 fr/1 w and 11 with the 28.5 Gy/5 fr/5 ws schedule. Median age was 67 and 70 in the two groups. Most of the patients had left-sided tumours (53.2%) in the 26 Gy/5 fr/1 w or right-sided lesions (63.6%) in the 28.5 Gy/5 fr/5 ws group. Most of the patients had a clinical T1N0 disease and a pathological pT1pN0(sn) after surgery. Ductal invasive carcinoma was the most frequent histology. Luminal A intrinsic subtyping was most frequent. Most of the patients underwent BCS and sentinel lymph node biopsy and adjuvant endocrine therapy. All patients completed the treatment program as planned. Maximum detected acute skin toxicities were grade 2 erythema (6.7%), grade 2 induration (4.4%), and grade 2 skin colour changes. No early IBTR was observed. Ultra-hypofractionated WBI provides favourable compliance and early clinical outcomes in EBC after BCS in a real-world setting
“but I am also influenced by no such thing”-The Radical Pietist and Theological Author Johanna Eleonora Petersen
No full textJohanna Eleonora von und zu Merlau, verheiratete Petersen, von jeher tief gläubig, veränderte die religiöse Welt des 17. Jahrhunderts. Sie bekannte sich zur Bewegung des Pietismus und vertrat radikale Ansichten, nicht nur im privaten Kreis, sondern als anerkannte und heftig kritisierte theologische Autorin. Ihrem Werk ist eine Studie gewidmet, in der neue Forschungsergebnisse vorgestellt und Leben und Werk dieser bedeutenden Autorin in zeitgenössische Diskurse eingebunden werden.The deeply devout Johanna Eleonora Petersen, whose maiden name was „von und zu Merlau,” changed the religious world of the seventeenth century. She avowed herself to Pietism and held radical views, not only in private but also as an acknowledged and sharply criticized theological author. This study attends to her work. It presents new research results and weaves the life and work of this important author into contemporary discourses
La notion de défectuosité du produit dans les jurisprudences des pays européens
No full textThis work analyses the notion of defective product originally developed by US Courts, then ambiguously defined by the European directive n. 374 of 1985 and differently interpreted and applied by the respective domestic Courts. In particular, some European jurisdictions apply the risk / utility test introduced by the US Courts for design defects cases, although this test is not mentioned by the European Directive. The author, having highlighted the inconsistences of the risk / utility test, proposes an alternative model of classification of defective products according to the elements actually used by judges in order to allocate the liability, as emerging from the text of their decisions. This classification leads to held the manufacturer strictly liable not only for manufacturing defects, but also for those design defects which he was aware of (as in some cases of defective vaccine).Cette étude examine la notion de défectuosité du produit initialement élaborée par les Cours américaines, définie de manière ambigüe par le législateur européen avec la directive n° 374 de 1985, puis différemment interprétée et appliquée par les Cours respectives des pays membres. Notamment certains systèmes juridiques européens appliquent le risk/ utility test élaboré par les Cours américaines pour les cas de défaut de conception du produit, bien que ce test ne soit pas mentionné par la directive européenne. L’auteur, après avoir mis en évidence les incongruences du risk/ utility test, propose un modèle alternatif de classification des cas de produits défectueux sur la base des critères d’imputation de la responsabilité qui sont concrètement utilisés par les juges et tels qu’imagés dans les textes de leurs décisions. Cette reconstruction amène à imputer au fabricant une responsabilité objective non seulement pour les cas de défaut de production, mais aussi pour les cas de défaut de conception dont il était averti (tel que certain cas de vaccin défectueux).Rajneri Karageorgevitch Eleonora. La notion de défectuosité du produit dans les jurisprudences des pays européens. In: Revue internationale de droit comparé. Vol. 67 N°1,2015. pp. 185-205
TO THE JUBILEE OF PROFESSOR STEPANOVA ELEONORA FEDOROVNA
No full textThe article is devoted to the anniversary of Professor Eleonora Fedorovna Stepanova – a bright representative of the Russian intelligentsia: a talented lecturer, an inventor, an author of numerous books, an internationally recognized scholar
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No full textHebb's idea of a cell assembly as the fundamental unit of neural information processing has dominated neuroscience like no other theoretical concept within the past 60 years. A range of different physiological phenomena, from precisely synchronized spiking to broadly simultaneous rate increases, has been subsumed under this term. Yet progress in this area is hampered by the lack of statistical tools that would enable to extract assemblies with arbitrary constellations of time lags, and at multiple temporal scales, partly due to the severe computational burden. Here we present such a unifying methodological and conceptual framework which detects assembly structure at many different time scales, levels of precision, and with arbitrary internal organization. Applying this methodology to multiple single unit recordings from various cortical areas, we find that there is no universal cortical coding scheme, but that assembly structure and precision significantly depends on the brain area recorded and ongoing task demands
Rescate y conservación del Acervo Histórico del Palacio de Minería: Informe de las labores de conservación preventiva e intervenciones menores en material Bibliohemerográfico y actividades en apoyo al Acervo Histórico : octubre 2011 - febrero 2012
No full textEl presente informe tiene como finalidad dar constancia de los trabajos realizados en el Acervo Histórico del Palacio de Minería, por los restauradores Roderick Palacios, Isabel Ritter y Eleonora Cruz, pasantes de la Licenciatura en Restauración de Bienes Culturales como prestación de su servicio social.</p
Tra quadro e cornice
No full textThe author presents a reconstruction of the experience she had in Pontedera when she saw some performances of the Workcenter of Jerzy Grotowski and Thomas Richards and took part to some works of the group. The text is composed by two parts: a descriptive and a theoretical one. In the first part, that she called “paintings”, the author tries to present his memory of what she saw and of what happened. Two plays are described, namely L’heure fugitive and The Underground, from the Focused Research Team in Art as a Vehicle, directed by Thomas Richards. After that, there is a description of open rehearsal of Thomas Richards’ group, in which the actors did singing exercises. The last activity was instead a singing session with Mario Biagini and his team, where the author and her colleagues participated actively. In the theoretical part, the author exposes her reflections concerning performances and other experiences, by focusing in particular on their meaning as well as on their major points of interest
Tra quadro e cornice. Resoconto di un viaggio a Vallicelle
No full textThe author presents a reconstruction of the experience she had in Pontedera when she saw some performances of the Workcenter of Jerzy Grotowski and Thomas Richards and took part to some works of the group. The text is composed by two parts: a descriptive and a theoretical one. In the first part, that she called “paintings”, the author tries to present his memory of what she saw and of what happened. Two plays are described, namely L’heure fugitive and The Underground, from the Focused Research Team in Art as a Vehicle, directed by Thomas Richards. After that, there is a description of open rehearsal of Thomas Richards’ group, in which the actors did singing exercises. The last activity was instead a singing session with Mario Biagini and his team, where the author and her colleagues participated actively. In the theoretical part, the author exposes her reflections concerning performances and other experiences, by focusing in particular on their meaning as well as on their major points of interest
Ius soli: qualche precisazione di metodo in materia di diritti di cittadinanza e diritti della cittadinanza
No full textThe Author analyses, among many possible meanings of citizenship, two types which had a part in the process of modern State building: citizenship is sometimes a relationship between the individual and the sovereign, sometimes consciousness of a collective membership. Both meanings have a link with the sovereignty and the process of modern State building. After the “great Neutralisation” of the Nineteenth Century, some reflections are developed about the relationship between citizenship and sovereignty in the Twentieth Century. Finally, the Author emphasizes the necessity of a statute that sets the requirements needed to become a citizen in order to pacify the conflicts of multicultural societies
Characterization of phenolic solid state pellets for ESR dosimetry with radio-therapeutic photon and electron beams
No full textIntroduction Among the various dosimetric techniques used for characterizing the radiation beams used in radiation therapy, the electron spin resonance (ESR) arouses increasing interest for applications in various therapy procedures. In this work we report the ESR investigation of particular phenol compound (IRGANOX 1076) exposed to clinical photon and electron beams (Gallo et al., 2017). Methods Phenol (IRGANOX 1076 - Sigma Aldrich) pellets were produced also with paraffin (10% by weight). Phenol pellets were exposed to clinical photon and electron beams at various energies produced by a linear accelerator (LINAC) Siemens Primus (Siemens Medical Systems, CA, USA) installed at the Radiotherapy Department of A.R.N.A.S. – Hospital Civico-Di Cristina-Benfratelli (Palermo) with absorbed doses ranging between 0 and 13 Gy. ESR measurements were performed through a X band Spectrometer. Readout parameters were optimized to maximise the signal without excessive spectrum distortions. Results Basic dosimetric properties of phenolic dosimeters, such as reproducibility, dose-response, sensitivity,linearity and dose rate dependence were investigated. A satisfactory intra-batch reproducibility of the ESR signal of the manufactured dosimeters was obtained. The analysis of the ESR signal as function of absorbed dose highlights that the response of this material is linear in the dose range investigated (1-13 Gy) and is independent of the beam energy. The presence of an intrinsic background signal limits the minimum detectable dose to a value of approximately 0.6 Gy. Reliable and accurate assessment of the dose was achieved, independently of the dose rate. The dosimeters were tested by measuring the depth dose profile of a 6 MV photon beam. Conclusion Such characteristics, together with the fact that IRGANOX 1076® is almost tissue-equivalent, and the stability of the ESR signal, make these dosimeters promising materials for ESR dosimetric applications in radiotherapy
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