12,690 research outputs found
What kind of surgery for cervical carcinoma?
No full textThe incidence and mortality of cervical cancer have changed over the past 50 years in developed countries, but this kind of tumor still remains a significant clinical problem because it is the second most common cause of morbidity and mortality from cancer among women.
After histological confirmation of invasive cervical cancer, the extent of disease was determined using clinical criteria to assign a stage. This assessment is important because, while for the other gynecologic cancers clinical information obtained by surgery and histopathological examination is implemented and concurs to define the staging of the disease, the cervical cancer tumor stage is given after the primary diagnosis.
In this review we discuss how the surgical approach to cervical cancer has been evolved, in order to modulate the radicality of the intervention itself and thus to preserve the pelvic innervation. This step has been achieved by deepening knowledge of functional pelvic anatomy and modulating the radicality of hysterectomy according to well defined surgical landmarks
MABS validation through repeated execution and data mining analysis
No full textAgent Based Modelling is the most interesting and advanced approach for simulating a complex system: in a social context, the single parts and the whole are often very hard to describe in detail. Besides, there are agent based formalisms which allow to study the emergency of social behaviour with the creation and study of models, known as artificial societies. Thanks to the ever increasing computational power, it's been possible to use such models to create software, based on intelligent agents, which aggregate behaviour is complex and difficult to predict, and can be used in open and distributed systems. Data mining is born in the last decades in order to help users in finding useful knowledge from the otherwise overwhelming amount of data available nowadays from the web and the data collected every day by companies. Data Mining techniques can therefore be the keystone to reveal non-trivial knowledge expressed by the initial assumption used to build the micro-level of the model and the structure of the society of agents that emerged from the simulation
Controlled nitrogen atmosphere for the preservation of functional molecules during silos storage: A case study using old Italian wheat cultivars
No full textIn the last decades, finding new methods to preserve the quality of wheat during post-harvest storage has become of primary importance to guarantee high-quality food products. Attacks by rodents and microorganisms, as well as humidity and high temperatures, are well-known factors affecting the qualitative and quantitative features of stored grains. The use of a controlled atmosphere saturated with different gases (such as carbon dioxide-CO2 and nitrogen-N2) is known to decrease the growth of microorganisms. Furthermore, the use of N2 is free of pollutants, thus being an environmental-friendly method. In this study, the use of a controlled atmosphere saturated with N2 was investigated as a method to preserve the nutraceutical qualities in two old Italian wheat cultivars (i.e. Verna and Cappelli). In particular, vitamin E (α-tocopherol), polyphenols and antiradical activity were quantified to highlight the differences between traditional storage methods and the use of a controlled atmosphere saturated with N2. The data obtained showed that the use of a N2-saturated atmosphere reduced the loss of functional molecules, especially vitamin E, in both cultivars, during long storage periods. Moreover, the present system is suitable for the storage of seeds of old varieties cultivated under organic agriculture. Overall, the results validate the efficacy of the storage method with N2 and suggest its possible use for wheat on an industrial scale
Relationship between plasma concentrations of the l-enantiomer of methadone and response to methadone maintenance treatment
No full textThis study evaluated the relationship between the plasma concentration of l-methadone and response to methadone in real-world patients, in order to identify a minimum plasma concentration above which methadone treatment is effective. Ninety-four patients with opioid dependence under maintenance methadone treatment were consecutively recruited. Response was defined as negative urine analyses in the three weeks prior to the blood sampling. The percentage of participants with a plasma l-methadone concentration between 100 and 250 ng/ml was 54.2% among those with a methadone dosage
Facades of the Libreria di San Marco in Venice, The: An Interpretation of the Design Process
No full text"A new work in which I propose an interpretation of the design process Sansovino used to create the magnificent facades of the Libreria di San Marco in Venice, a masterpiece of Renaissance architecture." Sent to Marquand librarian by author Dec. 202
Art without an Author: Vasari’s Lives and Michelangelo’s Death
No full textMonografia sulla rappresentazione di Michelangelo nelle due edizioni delle Vite, sulla storia del libro e la questione della sua paternitàBook dedicated to the representation of Michelangelo in Vasari's Lives of the Artists, to the history of the book, and to the problem of its authorshi
The 3' untranslated region of human contains regulatory elements affecting transcript stability
No full textBACKGROUND: CDK5R1 plays a central role in neuronal migration and differentiation during central nervous system development. CDK5R1 has been implicated in neurodegenerative disorders and proposed as a candidate gene for mental retardation. The remarkable size of CDK5R1 3'-untranslated region (3'-UTR) suggests a role in post-transcriptional regulation of CDK5R1 expression. RESULTS: The bioinformatic study shows a high conservation degree in mammals and predicts several AU-Rich Elements (AREs). The insertion of CDK5R1 3'-UTR into luciferase 3'-UTR causes a decreased luciferase activity in four transfected cell lines. We identified 3'-UTR subregions which tend to reduce the reporter gene expression, sometimes in a cell line-dependent manner. In most cases the quantitative analysis of luciferase mRNA suggests that CDK5R1 3'-UTR affects mRNA stability. A region, leading to a very strong mRNA destabilization, showed a significantly low half-life, indicating an accelerated mRNA degradation. The 3' end of the transcript, containing a class I ARE, specifically displays a stabilizing effect in neuroblastoma cell lines. We also observed the interaction of the stabilizing neuronal RNA-binding proteins ELAV with the CDK5R1 transcript in SH-SY5Y cells and identified three 3'-UTR sub-regions showing affinity for ELAV proteins. CONCLUSION: Our findings evince the presence of both destabilizing and stabilizing regulatory elements in CDK5R1 3'-UTR and support the hypothesis that CDK5R1 gene expression is post-transcriptionally controlled in neurons by ELAV-mediated mechanisms. This is the first evidence of the involvement of 3'-UTR in the modulation of CDK5R1 expression. The fine tuning of CDK5R1 expression by 3'-UTR may have a role in central nervous system development and functioning, with potential implications in neurodegenerative and cognitive disorders
How to prevent crimes using earthquakes
No full textIn this chapter the author describes how techniques coming from earthquakes prediction has been used to produce successful mathematical models useful in preventing crimes
The Research Agenda: Marco Bassetto on the Quantitative Evaluation of Fiscal Policy Rules
No full textMarco Bassetto is a Senior Economist in the Economic Research Department at the Federal Reserve Bank of Chicago. He is interested in political-economy models of fiscal policy and in applications of game theory to the analysis of macroeconomic policy more in general. This piece reflects the personal views of the author and not necessarily those of the Federal Reserve Bank of Chicago or the Federal Reserve System.
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