4,079 research outputs found
Glucuronxylomannan, a major capsular component of Cryptococcus neoformans, accumulates in human monocytes and neutrophils
No full textClaudia Rankine: An Evening with Claudia Rankine
No full textAn initiative of the National Endowment for the Arts in partnership with Arts Midwest, the NEA Big Read broadens our understanding of our world, our communities, and ourselves through the joy of sharing a good book. For NEA Big Read: Hampton Roads, that book is Citizen: An American Lyric.
NEA Big Read: Hampton Roads, the President\u27s Lecture Series, and the President\u27s Task Force on Inclusive Excellence invite you to a powerful evening with Claudia Rankine, the book\u27s author, hosted by Tim Seibles, Poet Laureate for the Commonwealth of Virginia, and opening with readings by local youth poets.
Claudia Rankine has written five collections of poetry, including Citizen: An American Lyric, which was selected for the National Endowment for the Arts\u27 Big Read, and two plays. She also has participated in several video collaborations and edited anthologies including The Racial Imaginary: Writers on Race in the Life of the Mind.
Rankine has received fellowships from the MacArthur and Guggenheim foundations. Citizen won several honors, including the National Book Critics Circle Award for Poetry, the PEN Open Book Award and the NAACP Image Award. Citizen also was the only poetry book to be a New York Times nonfiction bestseller. She is the Frederick Iseman Professor of Poetry at Yale University and chancellor of the Academy of American Poets
L-Phe-D-Oxd: A privileged scaffold for the formation of supramolecular materials
No full textSome compounds containing the L-Phe-D-Oxd [L-Phe = L-phenylalanine; D-Oxd = (4R,5S)-4-carboxy-5-methyl oxazolidin-2-one] moiety have been prepared and their properties as supramolecular material have been determined. Some derivatives of the dipeptide L-Phe-L-Phe (which usually forms nanotubes and some long-chain derivatives that behave as low-molecular-weight gelators have been prepared. We have also replaced the D-Oxd moiety with a D-Pro (D-Pro = D-proline moiety to check if the presence of the Oxd moiety was essential for the existence of those materials. In contrast to the D-Oxd-containing compounds, no material was ever formed with any of the D-Pro-containing molecules. This outcome suggests that the L-Phe-D-Oxd moiety may be defined as a "privileged scaffold" for the formation of supramolecular materials and it can be introduced into more complex structures to induce some selected properties in the solid state. Compounds containing the L-Phe-D-Oxd [L-Phe = L-phenylalanine; D-Oxd = (4R,5S)-4-carboxy-5-methyl oxazolidin-2-one] moiety have been prepared and their properties as supramolecular materialshave been determined. Some L-Phe-L-Phe dipeptide derivatives form nanotubes and other long-chain derivatives behave as gels. The effect of the D-Oxd moiety on the properties of the material was investigated. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
The expression and biological activity of CD88 (C5aR)on human neutrophils are limited by capsular material of Cryptococcus neoformans
No full textModulation of C5aR expression on human neutrophils by encapsulated and acapsular Cryptococcus neoformans.
No full textCryptococcus neoformans and cryptococcal surface polysaccharides influenced C5aR expression on human
polymorphonuclear neutrophils (PMN). Encapsulated and acapsular strains produced dramatically different
effects. Treatment of PMN with acapsular cryptococci up-regulated C5aR expression; whereas treatment with
encapsulated cells suppressed C5aR expression. Glucuronoxylomannan (GXM), the principal constituent of
the cryptococcal capsule, was responsible for such inhibition. Increased C5aR expression following treatment
with acapsular cryptococci was accompanied by increased binding of C5a to PMN, increased superoxide
production in response to stimulation with C5a, and an increased chemotactic response to C5a. Conversely,
decreased C5aR expression following treatment with encapsulated cryptococci or acapsular cryptococci that
had been pretreated with GXM was accompanied by decreased binding of C5a to PMN and a decreased
chemotactic response to C5a. Our results raise the possibility that the down-regulation of C5aR expression by
encapsulated cryptococci might alter PMN function at the site of cryptococcal infection
Role of accessory molecules in the regulation of protective immunity against Cryptococcus neoformans
No full textRegulatory role exogenus interleukin 10 in the development of immune response versus Cryptococcus neoformans
No full textPortrait of Claudia Lynn Pittman.
No full textHandwritten inscription: Claudia Lynn Pittman, 20 yrs old, Hattiesburg.https://egrove.olemiss.edu/joephoto_c/1129/thumbnail.jp
Il materiale capsulare del Cryptococcus neoformans limita l'espressione e l'attività biologica del CD-88 (C5aR) sui neutrofili umani
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