538 research outputs found
Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models
No full textSyzygium aqueum is widely used in folk medicine. A polyphenol-rich extract from its leaves demonstrated a plethora of substantial pharmacological properties. The extract showed solid antioxidant properties in vitro and protected human keratinocytes (HaCaT cells) against UVA damage. The extract also reduced the elevated levels of ALT, AST, total bilirubin (TB), total cholesterol (TC) and triglycerides (TG) in rats with acute CCl4 intoxication. In addition to reducing the high MDA level, the extract noticeably restored GSH and SOD to the normal control levels in liver tissue homogenates and counteracted the deleterious histopathologic changes in liver after CCl4 injection. Additionally, the extract exhibited promising anti-inflammatory activities in vitro where it inhibited LOX, COX-1, and COX-2 with a higher COX-2 selectivity than that of indomethacin and diclofenac and reduced the extent of lysis of erythrocytes upon incubation with hypotonic buffer solution. S. aqueum extract also markedly reduced leukocyte numbers with similar activities to diclofenac in rats challenged with carrageenan. Additionally, administration of the extract abolished writhes induced by acetic acid in mice and prolonged the response latency in hot plate test. Meanwhile, the identified polyphenolics from the extract showed a certain affinity for the active pockets of 5-lipoxygenase (5-LOX), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) explaining the observed anti-inflammatory activities. Finally, 87 secondary metabolites (mostly phenolics) were tentatively identified in the extract based on LC-MS/MS analyses. Syzygium aqueum displays good protection against oxidative stress, free radicals, and could be a good candidate for treating oxidative stress related diseases
Alternative Lime Based Grouts Used in Re-pointing of Deteriorated Ancient Mortars and their Structural Effects on Composite Unreinforced Masonry Walls of Mekaad Radwan, Ottoman Cairo, Egypt (Case Study)
No full textAbstractMortars and plasters of Mekaad Radwan are badly affected by decay hazards, therefore; they were studied by means of XRD and polarized microscope to detect their chemical composition, physical and petrographic properties, in addition to identify their characteristics. The analyses revealed gypsum mixed with lime as dominant component with some aggregates of sand particles, sodium chloride was detected in all the studied samples. Standardized alternative mortars were prepared, exposed to artificial aging and tested in order to select the most suitable type to replace the old mortars and plasters at Mekaad Radwan
Anisotropic Durgapal-Fuloria compact stars in f(R) gravity
No full textThis study presented a new exact solution for anisotropic compact stellar objects within the framework of f(R)=R+αR2 gravity. In this context, the Durgapal-Fuloria metric potential has been employed to solve the field equation derived for f(R) theory. Furthermore, we have derived the generalized Darmois-Israel junction condition necessary for seamlessly connecting the interior region to the Schwarzschild exterior metric across the boundary hypersurface of the star in the context of f(R) gravity, and the interior solution is matched with the Schwarzschild exterior metric over the bounding surface of a compact star. These junction conditions stipulate that the pressure must not be zero at the boundary and should be proportional to the non-linear terms of f(R) gravity, a crucial aspect often overlooked by many researchers when investigating compact stellar models. Additionally, we derived the values of these parameters by using observational data of various compact stars (CSs), namely Her X-1, SAX J1808.4-3658, SMC X-1, LMC X-4, Cen X-3, 4U 1820-30, PSR J1903+327, 4U 1608-52, Vela X-1, and PSR J1416-2230. This approach enables us to investigate the comprehensive analysis of solutions numerically and graphically. We conducted various physical tests, including gradient of energy density and pressures, anisotropy, stability, equilibrium conditions, energy-density constraints, mass function, compactness, redshift, and adiabatic index, to assess the feasibility of our models. Our findings demonstrate the consistent behavior of our models provides a satisfactory physical situation as far as the observational results are confirmed
Geognostic Investigation on Damage and Deterioration Evolution of Soil and Architectural Materials of Mekaad Radwan, Ottoman Cairo, Egypt (Case Study)
No full textAbstractThis study determines which factors play roles of deterioration in Mekaad Radwan. The study also makes it possible to know the real response of the masonry structure to the deformation imposed at the base of the foundation condition. The used methodology included the identification of the seismicity situation and the possible damage effects of the Cairo (1992) earthquake through discussion of situation before and after earthquake as well as the controlling factors, in addition to the analysis and determination of the types, geometry of the types, deformation and other deterioration patterns, using the direct observation and primitive monitoring evaluation
Electrical and optical properties of indium-modified SeSbTe thin films for low power memory devices
No full textThe electrical and optical characteristics of indium doped Se 2Sb2Te6 phase-change alloy are studied. It is found that adding indium to Se2Sb2Te6 alloy (In0.3Se2Sb2Te6) increased the crystallization temperature and reduced the electrical conduction activation energy. The capacitance-temperature measurements showed a drastic change in the capacitance of the modified film when the temperature approaches the crystallization temperature, and eventually the capacitance becomes negative and nonlinear. The negativity and nonlinearity in the capacitancevoltage dependence can be attributed to the growth of conductive crystalline islands by increasing the temperature. © (2011) Trans Tech Publications, Switzerland.Erwin R., 2006, OPTICAL DATA STORAGE; Ghamlouche H, 2008, J PHYS D APPL PHYS, V41, DOI 10.1088-0022-3727-41-21-215303; Lee EB, 2009, MICROELECTRON ENG, V86, P1950, DOI 10.1016-j.mee.2009.03.089; Mahmoud ST, 2008, J NON-CRYST SOLIDS, V354, P1976, DOI 10.1016-j.jnoncrysol.2007.11.014; Mott N. F., 1979, ELECT PROCESSES NONC; Nakayama K, 2007, J PHYS D APPL PHYS, V40, P5061, DOI 10.1088-0022-3727-40-17-009; Penin A. N., 1996, SEMICONDUCTORS, V30, P340; Shin HJ, 2008, APPL PHYS LETT, V93, DOI 10.1063-1.2959730; Xia JL, 2005, CHINESE PHYS LETT, V22, P934, DOI 10.1088-0256-307X-22-4-0430
Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System
No full textVirus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system
UniCouncil_1957_124
No full text•9'
Name Class Remarks
213* Michel Spiridon Sophomore Chem*
2lit, Mireille E* Mordo Senior Econ* in
215* Mohamed Abdel Halim Khodeir Freshman
216. Mohamed Hassan Faki Sophomore P*S,
217» Mohamed Ibrahim SI Disouki Freshman
218, Mohamed Kamel Mohydeen Moh*d Junior B.A*
219* Mohamed Mahmoud Nawar Ali Sophomore P.S .
220* Mohamed Midhat Hussein Senior B.A. — if f
221. Mohamed Sayed Moftah Freshman
222, Mokhlis Zaki Yacoub Freshman
223* Mona El Houte Junior Soc,
22U* Mona Said Megahed Sophomore P.S,
22Morris Alexander Kabashi Freshman
226, Moufid Gamil Khoury Freshman
227, Mounira Yousef Sonbol Sophomore
228, Myrna Daz z i Senior Soc, -— 10 ?
229. Nabil Adib Mohantncd Junior B.A.
230* Nabil Daniel Tadros Junior Chem,
231* Nabil Daoudi Dajani Sophomore B.A.
232* Nabil Naguib Sa*d Sophomore Chem,
233* Nabil Taji Farouki Freshman
23iu Nabil Wahba Barsoum Sophomore Chem*
235* Nabila Fahim El Daif Junior Soc* ,
236, Ndaila Hassan Dajani Freshman j
237* Nadia Dajroish Senior Phil. H
238, Nadia Slsayed Elshazly Senior Journ. ——- 10’
Enhanced Role of Grapefruit Juice on the Anti-schistosomal Activity of Artemether on the Liver of Schistosoma haematobium Infected Hamsters
No full textArtemether (ART) is an efficacious anti-malarial drug that also displays antischistosomal properties. Laboratory studies have found that ART curtails the development of schistosoma worms and thus prevents morbidity. Grapefruit juice was found to interact with various drugs that have been metabolized by a form of Cytochrome P450, CYP3A4, thus increasing the plasma drug concentration. This work aimed to study the effect of grapefruit juice when administered before infection with Schistosoma haematobium and/or treatment with ART on its anti-schistosomal activity. Golden hamsters were infected each with 300 S. haematobium cercariae and divided into 6 groups (A – F), as follows: Infected control (A); infected received grapefruit juice before infection (B); or received grapefruit juice before infection and treated with ART (200 mg/k) at 5,6 and 7 weeks post infection (WPI) (C); or for 3 successive doses at 12 WPI (D); infected treated with ART alone (200 mg/k) at 5,6 and 7 WPI (E); infected received grapefruit juice (0.5 ml) half an hour before treatment with ART (200 mg/k) at 5,6 and 7 WPI (co-administration) (F). All groups were sacrificed 14 WPI. Some parasitological, biochemical and histopathological estimations were done. Results revealed that, the highest percent of worm reduction was observed in-group F (94.2%) compared to group C,E & D (87.3%, 77.6% & 65.9% respectively). The level of ALT, GGT, urea, thiol, albumin and alkaline phosphatase tend to normalize in accordance with the parasitological results. Neither hepatic granuloma nor prominent histopathological changes could be detected in group F. A minimal number of granulomas (1-3/animal) was observed in group E; meanwhile, the least diameter and collagen content of hepatic S. haematobium granulomas were observed in group C (125.6±5.5 & 2.4±0.572 respectively). The results of the present study demonstrated that, co-administration of grapefruit juice just before treatment with ART at 5, 6& 7 WPI enhanced its anti-schistosomal activity and improved the histopathological changes
Very ductile polymer concrete using carbon nanotubes
No full textReda Taha, Mahmoud M./0000-0002-3707-9336; Emiroglu, Mehmet/0000-0002-0214-4986WOS: 000456755400042Polymer concrete (PC) is a type of concrete where a polymer is used to replace cement as the binder. PC is an impermeable and chemical resistant concrete with appreciable mechanical properties. However, for most structural engineers, PC advantages do not outweigh its higher cost when compared with normal cement concrete. We report on the production of very ductile PC (measured by tensile strain at failure) with appreciable tensile strength utilizing a hybrid mixture of pristine and carboxyl (COOH) functionalized multi-walled carbon nanotubes (MWCNTs) at 2.0 wt% of epoxy resin. Experimental investigations reveal that COOH functionalization maximizes PC ductility reaching unprecedented 5.5% failure strains and increasing toughness by 184%. Fourier transformation infrared spectroscopy and dynamic modulus analysis indicate an increase in crosslinking density of the epoxy matrix up to 84% due to the carbonyl band formation induced by the COOH functionalization of MWCNTs. The significant improvement in ductility and energy absorption provides a promising platform for creating very ductile PC with attractive properties. (C) 2018 Elsevier Ltd. All rights reserved.Southern Plains Transportation Center (SPTC), US Department of Transportation; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Egyptian Science and Technology Development FundScience and Technology Development Fund (STDF) [STDF-CSE 5213]This work has been funded by Southern Plains Transportation Center (SPTC), US Department of Transportation, contract to The University of New Mexico. The authors greatly acknowledge this support. The second author acknowledges financial support from the Scientific and Technological Research Council of Turkey (TUBITAK) BIDEB-2219 Postdoctoral Research program. Finally, support to the third author by the Egyptian Science and Technology Development Fund (STDF-CSE 5213) is also appreciated. Donation of polymer concrete materials by Transpo Industries, Inc. is much acknowledged
Effect of vardenafil on diabetic foot ulcer (DFU) in rats
No full textThe present study was designed to investigate the possible effect of vardenafil phosphodiesterase-5 inhibitor on diabetic foot ulcer induced in rats and the underlying mechanism(s).
Streptozotocin -induced diabetic rats were treated with the phosphodiesterase-5 inhibitor, vardenafil, for 8 weeks starting on day 15 after Streptozotocin injection. After 4 weeks of treatment, a wound of fixed size was induced in the dorsal surface of right foot and wound size measured every 3 days. Behavior tests (foot print and hotplate test) were performed every 2 weeks. At the end of the study, animals were euthanized, body weight, serum insulin, glucose, glycated haemoglobin, interlukin-6, adiponectin and hematoxylin and eosin stained sections were investigated.
Diabetes resulted in delayed wound healing, elevated blood glucose, HbA1c, IL-6, reduced serum insulin and adiponectin, treatment with vardenafil lead to improvement in all tested parameters.
In conclusion, the phosphodiesterase 5 inhibitor vardenafil can be used for the treatment of diabetic foot ulcer (DFU) since it is already used for other indications. Further studies are required to confirm its effects either alone or combined with other antidiabetic therapies
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