15 research outputs found
Azithromycin as potent inhibitor of cell migration in tumor cell line
No full textContinuous obstacles behind the discovery of novel drugs for cancer therapy have necessitated
the development of alternative strategy of drug repurposing—the development of old drugs for new therapeutic
purposes. With an improved understanding of the hallmarks of cancer, this strategy offers a cost-effective process
for the treatment of human neoplastic disease, thereby facilitating rapid clinical translation. In this regard, macrolide
antibiotics (MAs), which include a wide spectrum of activities against Gram-positive bacteria, have also been
proposed as anticancer drugs for multiple tumor types. Over the past few years, significant progress has been
achieved in anticancer therapy, but development of resistance and unavoidable side effects have weakened these
attainments. Considering this severe condition, a number of drugs with novel antitumor mechanisms are under
investigations including antimicrobials that have been shown to possess anti-inflammatory, immunomodulatory,
and cytotoxic effects. In this regard, both conventional and novel antimicrobials are being studied to explore their
anticancer potential along with underlying mechanisms that may render them as effective anticancer drugs in the
future. Hence, in the latest study, we tested the role of a macrolide antibiotic drug, Azithromycin (AZM) alone, in
combination with standard chemotherapeutic agent Sorafenib (Sorafenib/AZM) and its gold conjugated
nanoparticles (AuAZM) as an anti angiogenic agent in hepatoma cell line hepG2 through wound healing assay. The
migratory potential of HepG2 cells after being exposed to different treatments (AZM, Sorafenib, Sorafenib/AZM,
and Au-AZM at IC50 concentrations) was observed at 0, 6, 24, 48, and 72 hours. The results of our study showed
that AZM exhibited highly significant reduction in wound healing with p-value (< 0.001) up till 72 hours, while
Sorafenib, Sorafenib/AZM, and Au-AZM inhibited wound healing up to 48 hours (p-value < 0.001). The current
study revealed a comparatively higher antiangiogenic potential of AZM in cancer cells, thereby suggesting its
clinical application for cancer treatment
A critical analysis of Persian Poetry of Shah Turab Ali Qalandar
No full text<p>volume = {1}, number = {1}, author = {Zunnoorain Haider Alavi}, title = {A critical analysis of Persian Poetry of Shah Turab Ali Qalandar}, publisher = {Saurabh Chandra}, journal = {SOCRATES}, ISSN 2347-6869 year = {2013}</p
The Poetics of Textual Thresholds in Ahcene El-Kharrat’s Collections of Poetry
No full textAbstract: The aim of this study is to analyze the poetics of textual thresholds in the poetry of Ahcene El-Kharrat (1989-2019), to query their various dimensions, connotations and artistic features, based on the assumption that contemporary poetic text is no longer just a set of poems nicely written and collected in a book, but rather a mosaic of written texts, para (meta) texts, and thresholds related to their hypertext. The thresholds’ role is vital. Its importance cannot be ignored while formulating the general poetic context of the poem. The latter cannot reach completeness without its textual thresholds that opens up new poetic and artistic perspectives. We will shed light, in this analytical and intertextual research, on the thresholds of the poems in the collections of the Algerian poet Ahcene El-Kharrat entitled: Nabdh-al-faji’a (Pulse of Bereavement), Basar Al-Turab (Sight of the earth) and Shatah Al-darawishes (the Dervishes’ imagination).
Keywords: Textual Thresholds; Paratext; Connotation; Author; Poetic
Seismic Site Amplification Characteristics of Makran Subduction Zone Using 1D Non-Linear Ground Response Analysis
No full textThe Makran Subduction Zone (MSZ) is a tectonic plate boundary where the Arabian Plate is subducting beneath the Eurasian Plate. This study investigated the dynamic response in the Gwadar region, located in the eastern part of the MSZ. A suite of seismic records compatible with the Building Code of Pakistan (BCP:2021) rock design spectrum was used as the input ground motions at the bedrock. The amplification characteristics were assessed through a series of one-dimensional (1D) site response analyses utilizing a non-linear (NL) approach. The results revealed significant de-amplification in soft soils at short spectral periods. A general depth-wise decrease in the shear stress ratio and peak ground acceleration values was observed, influenced by shear-strain-induced effects and shear wave velocity reversals within the site profiles. The code spectra, compared to the proposed design spectra, underestimated the site amplification for stiff soils (i.e., Site Class D) for periods of less than 0.32 s and overestimated it for soft soils (i.e., Site Class E) across all periods. These findings underscore the necessity for site-specific ground response analyses, particularly within the framework of the China–Pakistan Economic Corridor (CPEC)
ANTI HYPERTENSIVE EFFICACY OF CARDIOSELECTIVE BETA-BLOCKER ATENOLOL AND AMLODIPINE IN ESSENTIAL HYPERTENSIVE PATIENTS
No full textABSTRACT High blood pressure increases the risk of cardiovascular disease for millions of people worldwide and there is evidence that the problem is only getting worse. In the past decade, age adjusted rates of strokes incidence have risen. The incidence of end stage renal disease and the prevalence of heart failure have also increased. A major contributor to these trends is inadequate control of blood pressure in the population. The variety of treatments has been established with the passage of time from older to newer class. Researchers with passage of time proved on one side beneficiary drugs but also contraindicated in various types of patients. Keeping in view the necessity of treatment of hypertension at its initial stages in essential hypertensive patients to prevent cardiovascular complications in essential hypertensive patients. In present study the objective was to compare blood pressure lowering effects of cardio selective beta blocker Atenolol with calcium channel blocker Amlodipine in essential hypertensive patients
Hematological and Histomorphological Amelioration by Withania Somnifera of Cisplatin-induced Splenotoxicity in Rats
No full textObjective: This study was designed to analyse the toxic effects of the anti-cancer drug cisplatin on rat spleen and blood parameters and its amelioration by the root extract of a naturally occurring antioxidant Withania Somnifera.
Methods: This experimental study was conducted in Baqai Medical University and Jinnah Medical and Dental College, Anatomy department, after the approval of Institutional Animal Ethical Committee. 60 male Albino Wistar rats, 14-16 weeks old and weighing 200-250gm were randomly divided in to 4 groups. Group A received no treatment, group B was given intraperitoneal injection of Cisplatin only for, group C received a combination of IP cisplatin and W. somnifera root extract orally and group D was given W. somnifera root extract only. Initial and final body and splenic weights, blood and histological analysis was carried out and difference between the groups were recorded. Statistical analysis of data was done using SPSS version 25.0.
Results: The rats of Cisplatin only group B showed significant toxic changes in splenic histology: thickened splenic capsule, white pulp reduction with reduced PALS areas, central artery vacuolization. These changes were improved in cisplatin and W. somnifera group C. Blood profiles showed decreased Hb, TLC and platelets in cisplatin only group B but it was improved in the cisplatin and W. somnifera group C.
Conclusion: Our study concluded that the W. Somnifera root extract protects against cisplatin induced damage to splenic tissue and hematological alterations in rat model. This ponders on its potential as an adjuvant therapy with anticancer cisplatin treatment for minimizing its side effects.
Correlation between structural, electrical, dielectric and magnetic properties of semiconducting Co doped and (Co, Li) co-doped ZnO nanoparticles for spintronics applications
No full text5.8 Mirpur, Pakistan, earthquake using near‐surface electrical resistivity tomography and geological data
No full textEarly childhood cognitive development is affected by interactions among illness, diet, enteropathogens and the home environment : Findings from the MAL-ED birth cohort study
No full textFunding Information: Funding The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation (#OPP47075), the Foundation for the NIH and the National Institutes of Health/Fogarty International Center. The Bill & Melinda Gates Foundation did not play any role in the writing of the manuscript nor did the funders of the study have any role in the study design, data collection, data analysis or interpretation of study results. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Publisher Copyright: © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Peer reviewe
Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years : Results from MAL-ED
No full textFunding Information: The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the NIH, and the National Institutes of Health/Fogarty International Center. This work was also supported by the Fogarty International Center, National Institutes of Health (D43-TW009359 to ETR). Author disclosures: BJJM, SAR, LEC, LLP, JCS, BK, RR, RS, ES, LB, ZR, AM, RS, BN, SH, MR, RO, ETR, and LEM-K, no conflicts of interest. Supplemental Tables 1–5 and Supplemental Figures 1–3 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/. Address correspondence to LEM-K (e-mail: [email protected]). Abbreviations used: HOME, Home Observation for Measurement of the Environment inventory; MAL-ED, The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project; TfR, transferrin receptor; WPPSI, Wechsler Preschool Primary Scales of Intelligence.Peer reviewe
