52 research outputs found
Protective efficacy of Murraya koenigii aqueous extract against monosodium glutamate-induced hepatotoxicity in Wistar rats
No full text188-196The present work was designed to study the potential effect of antioxidant rich aqueous extract of Murraya koenigii (AE-MK) on monosodium glutamate-induced hepatotoxicity in Wistar rats. The study was conducted on thirty adult Wistar rats, classified into six groups. MSG (1000 mg/kg, p.o) was administered to induce hepatotoxicity. The MSG treated group showed significant (P ˂0.05) increase in % change in body weight, relative organ weight, SOD, MDA, cholesterol, bilirubin, triglycerides, LDL levels; and AST, ALT activity while significant (P <0.05) decrease in glutathione peroxidase, albumin, HDL level and ALP activity in liver tissue as compared to control group. AE-MK (200, 400 mg/kg) significantly (P <0.05) reversed all the above parameters as compared to MSG treated rats. Histopathological changes observed in MSG treated rat liver tissue were cytoplasmic vacuolation, sinusoidal congestion, and cellular aggregates around the portal area. These changes were reversed with AE-MK (200, 400 mg/kg). The total phenol content was found to be 62 μg of gallic acid equivalent /mg of extract and free radical scavenging activity by DPPH method was found to be 74.16%. The study suggests that antioxidant rich aqueous extract of M. koenigii has protective effect against MSG-induced hepatotoxicity
Involvement of central noradrenaline, serotonin and dopamine system in the antidepressant activity of fruits of<i>Solanum torvum</i>(Solanaceae)
No full textEffect of A-HRS on blood pressure and metabolic alterations in fructose-induced hypertensive rats
No full textProtective effect of <em>Solanum torvum</em> on monosodium glutamate-induced neurotoxicity in mice
No full text351-359Solanum torvum is a well known traditional herbal medicinal plant used in many neurological disorders. The objective of the study was to evaluate the effects of S. torvum on monosodium glutamate (MSG) induced neurotoxicity. Swiss albino mice received MSG (1000 mg/kg, p.o) followed by a methanolic and hydroalcoholic extract of S. torvum (100 and 300 mg/kg, p.o) for 14 days. MSG-treated mice showed significant (ppS. torvum (100 and 300 mg/kg) showed normal behavior, significant (pppS. torvum extracts reversed the histopathological changes induced by MSG. The study suggests that S. torvum seed extracts have the potential to ameliorate neuronal damage induced by MSG. Total flavonoid content of methanolic and hydroalcoholic extract of S. torvum was found to be 44±1.2 and 32±0.8 µg of rutin equivalent/mg of extracts and total phenolic content was found to be 70±0.28 and 52±0.62 µg of gallic acid equivalent/mg of extracts respectively
Protective effect of ethanolic extract of <i>Psidium</i> <i>guajava </i>L. leaves in tacrine-induced orofacial dyskinesia by assessing its neurobehavioral and biochemical alterations in rats
No full text277-281The present study investigated the protective effect of the ethanolic extract of Psidium guajava L. against tacrine-induced orofacial dyskinesia in rats. Behavioral assessments such as vacuous chewing movements, tongue protrusions, orofacial bursts, locomotion, and cognition were recorded. Forebrain of tacrine treated animals was assessed for its antioxidant levels. P. guajava (100 and 200 mg/kg, p.o.) significantly (P P P. guajava (100 and 200 mg/kg, p.o.) exhibited significant elevation in the levels of superoxide dismutase, catalase, glutathione reductase and inhibition of lipid peroxidation in the forebrain region as compared to the tacrine treated group of animals. Results suggest that P. guajava extract (100 and 200 mg/kg) has good potential to ameliorate tacrine induced orofacial dyskinesia
Protective effect of <i style="mso-bidi-font-style: normal">Psidium guajava </i>L. leaves ethanolic extract on doxorubicin-induced nephrotoxicity in rats
No full text129-133The objective of the present study was to
investigate the protective effect of ethanolic extract of <i style="mso-bidi-font-style:
normal">Psidium guajava L. leaves against doxorubicin-induced
nephrotoxicity in rats. Animals treated with doxorubicin (8mg/kg, i.p) once
daily for
2 days significantly (P<0.05) increased Serum Urea, BUN, creatinine, total protein,
LPO and significantly (P<0.05)
decreased CAT, SOD, GSH levels as compared to vehicle treated rats. Treatment
with P. guajava (100 & 300 mg/kg,
p.o) showed significant (P<0.05)
decrease in Serum Urea, BUN, creatinine, total protein, LPO and significant (P<0.05) increase in CAT, SOD, GSH
levels as compared to doxorubicin treated group. Histopathological examinations
of kidney tissue showed that doxorubicin changed the renal architecture
significantly which was less evident in P.
guajava
(100 mg/kg & 300 mg/kg) pre-treated rats. Results suggest that P. guajava extract has the potential to
ameliorate doxorubicin induced nephrotoxicity and might serve as a novel
combination agent with doxorubicin to limit renal damage
Intravenous human umbilical cord blood improves elctrophysiological and metabolic properties in ISO induced myocardial necrosis in rats
No full text228-234Rats
treated with isoproterenol (ISO, 85 mg/kg, sc, twice at an interval of 24 h)
showed a significant increase in heart rate, mean arterial blood pressure,
pressure rate index, ST elevation on ECG, and a significant increase in the
levels of cardiac marker enzymes- lactate dehydrogenase, and creatine kinase in
serum and a significant reduction in superoxide dismutase, and catalase and
increase in thiobarbituric acid reactive substance activity in heart tissue.
Treatment with <span style="font-size:9.0pt;mso-bidi-font-size:
11.0pt" lang="EN-GB">Human umbilical cord blood
(hUCBC; 500 and 1000 µL,
iv, via the tail vein; 2 h after the second dose of ISO<span style="mso-bidi-font-weight:
bold">) significantly restored back to normal levels and showed a lesser
degree of cellular infiltration and infarct size in histopathological and
planimetry studies respectively. Thus, hUCBC ameliorates cardiotoxic
effects of isoproterenol and may be of
value in the treatment of myocardial infarction.
</span
Effect of pomegranate juice on Angiotensin II‐induced hypertension in diabetic wistar rats
No full textEffect of ethanolic extract of <i style="mso-bidi-font-style:normal">Coriandrum sativum</i> L. on tacrine induced orofacial dyskinesia
No full text292-296The effect of ethanolic extract of <i style="mso-bidi-font-style:
normal">Coriandrum sativum L. seeds (100, 200 mg/kg) was studied on tacrine
induced orofacial dyskinesia. Tacrine (2.5 mg/kg, i.p.) treated animals were
observed for vacuous chewing movements (VCM), tongue protrusions (TP) and
orofacial bursts (OB) for 1 h followed by observations for locomotor changes
and cognitive dysfunction. Sub-chronic administration of <i style="mso-bidi-font-style:
normal">Coriandrum sativum L. seed extract (E-CS) (100, 200 mg/kg, p.o., for
15 days significantly (P <0.05)
decreased the tacrine induced VCM, TP and OB;
and also significantly (P <0.05),
increased locomotion and cognition compared to the tacrine treated group. Biochemical
analysis revealed that tacrine administration significantly (P <0.05) decreased the levels of
superoxide dismutase (SOD), Catalase (CAT), glutathione reductase (GSH) levels
and also significantly (P <0.05)
increased lipid peroxidation (LPO) as an index of oxidative stress, whereas
sub-chronic administration of E-CS significantly (<i style="mso-bidi-font-style:
normal">P <0.05) improved the antioxidant enzyme (i.e. SOD, CAT, and
GSH) levels and also significantly (P
<0.05) decreased lipid peroxidation (LPO). The results have demonstrated the
protective role of ethanolic extract of Coriandrum
sativum. L against tacrine induced orofacial dyskinesia
Protective effect of Solanum torvum on monosodium glutamate-induced hepatotoxicity and nephrotoxicity in rats
No full text31-42The objective of the study was to determine the protective effect of Solanum torvum on Monosodium glutamate (MSG) induced hepatotoxicity and nephrotoxicity in rats. Wistar rats received MSG (1000 mg/kilogram, per oral) followed by methanolic and hydroalcoholic extracts of S.torvum (100 & 300 mg/kg, p.o.) respectively for 14 days. Percentage change in body weight, relative organ weight of liver and kidney, liver function tests, kidney function tests and histopathological studies of liver and kidney tissues were observed in rats. In vitro antioxidant activity of S.torvum extracts was also performed. The results were analysed by One-way ANOVA followed by Dunnett’s test. The msg-treated group showed significant (p S. torvum extracts ameliorated the effects induced by MSG group. Total flavonoid content of methanolic & hydroalcoholic extract of S. torvum was found to be 44±1.2&32±0.8µg of rutin equivalent/mg of extract and total phenolic content was found to be 70±0.28 & 52±0.62 µg of gallic acid equivalent/mg of extract respectively. In vivo and In vitro antioxidant studies of both extracts showed that methanolic extract has more hepatoprotective, nephroprotective and anti-oxidant property than the hydroalcoholic extract of S.torvum fruits. It is concluded that S.torvum extract has a protective effect against MSG-induced hepatic and renal toxicity
- …
