7 research outputs found
Epidemiological Patterns of Skin Disease in Saudi Arabia: A Systematic Review and Meta-Analysis
No full textBackground. Large epidemiological studies on patterns of skin diseases in Saudi Arabia are scarce. Therefore, this systematic review and meta-analysis was conducted to gather available epidemiologic data describing the pattern of skin diseases in different geographical areas in Saudi Arabia. Methods. A comprehensive literature search of articles was conducted in PubMed, SCOPUS, and Web of Science through October 2019. We included all published cross-sectional studies that provided data on relevant incidence or prevalence of skin disease in Saudi Arabia. The risk of bias within the included cross-sectional studies was assessed using the Hoy tool for the prevalence studies. All statistical analysis was performed using the Comprehensive Meta-analysis software. Results. The present meta-analysis included 14 studies that reported the frequency of the skin disease patterns in different regions in Saudi Arabia with a total sample size of 30436 patients with an overall low risk of bias. The diseases of skin appendages and dermatitis were the most commonly reported skin diseases in Saudi Arabia (24.8% (95% CI, 24.3–25.3) and 24% (95% CI, 23.6%–24.6%), respectively). Skin infection represented about 18.5% (95% CI, 18.1%–19%), while the papulosquamous disorders represented 5.3% (95% CI, 5%–5.6%) of the skin diseases in Saudi Arabia. Skin cancers were pooled from only two studies. Basal cell carcinoma and squamous cell carcinoma were the most common malignant neoplasm in Saudi Arabia (51.4% and 22.5% of the malignant neoplasm, respectively), while malignant melanoma represents only 3.8% of the malignant skin cancer. Conclusion. Adnexal disorders and dermatitis are the most common skin disease in Saudi Arabia, followed by skin infection and pigmentary disorders. While skin cancer is more frequent than other countries, awareness campaigns should be initiated to increase knowledge about the harmful effect of long-term sun exposure
Bath Psoralen-ultraviolet A and Narrowband Ultraviolet B Phototherapy as Initial Therapy for Early-stage Mycosis Fungoides: A Retrospective Cohort of 267 Cases at the University of Toronto
No full textManagement of Atopic Dermatitis in Adults in Saudi Arabia: Consensus Recommendations from the Dermatological Expert Group
No full textAbdullah Alakeel,1 Afaf Al Sheikh,2,3 Ali A Alraddadi,4– 6 Khalid Mohammed Alattas,7 Maha Aldayel,8 Mohammed Abdulaziz Alajlan,9 Mohammed Al-Haddab,1 Mohammad Almohideb,3,10 Mohamed Fatani,11 Issam R Hamadah,12 Ruaa Alharithy,13,14 Yousef Binamer,15,16 Kim Papp,17 Ahmed Elaraby18 1Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Division of Dermatology, Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia; 3Department of Dermatology, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 4Department of Dermatology, Ministry of National Guard-Health Affairs, Jeddah, Saudi Arabia; 5King Abdullah International Research Center, Jeddah, Saudi Arabia; 6King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 7King Fahad Central Hospital, Jazan, Saudi Arabia; 8Dammam Medical Complex, Dammam, Saudi Arabia; 9Dermatology Section MSD, King Fahad Medical City, Riyadh, Saudi Arabia; 10King Abdulaziz Medical City, Riyadh, Saudi Arabia; 11Hera General Hospital, Makkah, Saudi Arabia; 12King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; 13Security Forces Hospital, Riyadh, Saudi Arabia; 14Princess Nourah University, Riyadh, Saudi Arabia; 15Department of Dermatology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; 16Department of Dermatology, Alfaisal University, Riyadh, Saudi Arabia; 17Probity Medical Research Inc. and K. Papp Clinical Research Inc., Waterloo, ON, Canada; 18Bachelor of pharmacy, Cairo University, Giza, EgyptCorrespondence: Issam R Hamadah, Email [email protected]; [email protected]: Atopic dermatitis (AD) is a long-term, pruritic, recurrent, systemic, inflammatory skin disorder. In the Middle East region, the burden of AD is understudied, and there is a dearth of AD guideline documents for practitioners.Methods: An expert panel meeting, encompassing 12 dermatologists from the Kingdom of Saudi Arabia (KSA), was congregated to develop evidence- and experience-based consensus recommendations for AD management, especially in adults in KSA. They completed a questionnaire with seven clinical statements, and a consensus was defined when the responses of ≥ 75% of participants coincided.Results: The expert recommendations were as follows: American Association of Dermatology guidelines are to be followed for defining AD; Eczema Area and Severity Index or SCORing atopic dermatitis index may be used to quantify the disease severity; Dermatology Life Quality Index may be used to determine the impact of AD on patients’ quality of life; Atopic Dermatitis Control Tool may be used to assess long-term disease control in AD patients; and the European guidelines are to be followed for the management of AD. In AD patients who are inadequately controlled with topical or systemic therapies, the preferred systemic agent for use either alone or in combination with topical treatments is dupilumab, cyclosporine, methotrexate, phototherapy, or other available systemic treatments that may include mycophenolate mofetil or oral corticosteroids.Conclusion: These expert recommendations assist physicians by providing a reference framework for optimal care of adult AD patients.Keywords: atopic dermatitis, Dermatology Life Quality Index, Eczema Area and Severity Index, SCORing atopic dermatiti
Prevalence and association of renal disorders in Saudi adult patients with psoriasis and psoriatic arthritis: a tertiary-center retrospective cross-sectional study
Get PDFPsoriasis, a chronic inflammatory skin disease, is connected to psoriatic arthritis, a chronic inflammatory arthritis. Recent studies have also linked psoriasis and psoriatic arthritis to various renal disorders. This research aims to determine the prevalence and association of renal disorders in adult patients with psoriasis and compare those findings with adult patients with psoriatic arthritis. This retrospective cross-sectional study included 485 participants with psoriasis. The study evaluated demographics, psoriasis type, the presence of psoriatic arthritis, and related comorbidities, excluding individuals under the age of 18 or those with no verified diagnosis. Medical records were reviewed for renal problems, and a multivariate logistic regression was used to investigate the relationship between psoriasis and psoriatic arthritis. Overall, 10.1% of psoriatic individuals had psoriatic arthritis. The mean age at diagnosis was 41.59±15.58 years, with 54.2% female. Plaque psoriasis was identified in 87.2% of patients, with 46% classified as obese (BMI≥30). Chronic renal failure was seen in 6.2% of psoriasis patients, and 6.1% of psoriatic arthritis patients. In our study, chronic renal failure rates were similar in psoriasis and psoriatic arthritis. Psoriatic arthritis was associated with an increased risk of acute kidney damage, transplantation, and dialysis
Bullous Pemphigoid Patients and Associated Malignancies: Retrospective Study; Riyadh – Saudi Arabia
Get PDFObjectives The purpose of this study is to describe the prevalence of bullous pemphigoid (BP) and to determine the associated malignancies with BP in Saudi Arabia.Methods Data on patients aged more than 18 years old, who were diagnosed with BP, were retrospectively reviewed. Patients’ sociodemographic, clinical symptoms and associated medical conditions were collected. Data were analyzed using the statistical package for social sciences, version 21 (SPSS, Armonk, NY: IBM Corp.).Results Our sample was composed of 83 patients who were diagnosed with bullous pemphigoid; their mean age was 80.3 years. 3.6 per cent of our patients had drug-induced BP. 97.6 per cent of our patients had comorbidities, such diabetes, hypertension, and dementia. The most commonly encountered co-morbidities were hypertension in 79.51 per cent patients (n=66) followed by diabetes in 51.80 per cent patients (n=43), and heart disease in 33.73 per cent patients (n=28). None of the patients had malignancies, except for 2.4 per cent patients (n=2) who had lymphoma. Conclusion No clear association between BP and malignancies, age group, gender, or other comorbidities was identified. We recommend larger prospective studies to investigate the association between BP and malignancies
Correlation between polio immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study
No full textWe conducted the current analysis to determine the potential role of polio vaccination in the context of the spread of COVID-19. Data were extracted from the World Health Organization’s (WHO) Global Health Observatory data repository regarding the polio immunization coverage estimates and correlated to the overall morbidity and mortality for COVID-19 among different countries. Data were analyzed using R software version 4.0.2. Mean and standard deviation were used to represent continuous variables while we used frequencies and percentages to represent categorical variables. The Kruskal-Wallis H test was used for continuous variables since they were not normally distributed. Moreover, the Spearman rank correlation coefficient (rho) was used to determine the relationship between different variables. There was a significantly positive correlation between the vaccine coverage (%) and both of total cases per one million populations (rho = 0.37; p-value < 0.001) and deaths per one million populations (rho = 0.30; p-value < 0.001). Moreover, there was a significant correlation between different income groups and each of vaccine coverage (%) (rho = 0.71; p-value < 0.001), total cases per one million populations (rho = 0.50; p-value < 0.001), and deaths per one million populations (rho = 0.39; p-value < 0.001). All claims regarding the possible protective effect of Polio vaccination do not have any support when analyzing the related data. Polio vaccination efforts should be limited to eradicate the disease from endemic countries; however, there is no evidence to support the immunization with live-attenuated vaccines for the protection against COVID-19
