324 research outputs found
CANADA, NOVA SCOTIA, NEW BRUNSWICK, & THE NORTHERN STATES
No full textSteel engraved. Includes inset map of Newfoundland in the bottom right corner, to the same scale as the map.Scale bar in English miles
Transcriptomic investigation of the adaptation of Streptococcus pneumoniae
No full textStreptococcus pneumoniae colonises the human nasopharynx as a commensal but can translocate to the lungs, meninges, and blood to cause potentially fatal infections. These host niches exhibit diverse physiological environments. Differences in adaptation to these conditions may explain differences between serotypes and genotypes in their ability to colonise the human host, be transmitted, and to cause disease. RNA sequencing (RNA-Seq) was used to investigate adaptation of clinical S. pneumoniae strains to different stress environments. In Chapter 3, to establish the optimal experimental conditions, the effects of carbohydrate source, temperature, and iron concentrations on bacterial growth dynamics were evaluated. S. pneumoniae strains selected on the basis of their ability to be carried and cause disease, showed differential growth phenotypes. In Chapter 4, to facilitate robust transcriptomic analysis, high-quality genome assemblies of S. pneumoniae serotype 1 (highly invasive, rarely found in carriage) and serotype 6B (rarely invasive, highly carried) strains were generated and characterised. A pneumococcal transcriptomic analysis pipeline was developed in Chapter 5 by investigating the transcriptomic response of two single gene knockouts of S. pneumoniae serotype 6B lacking the biosynthesis genes fhs or proABC. These mutants have been shown to be attenuated in vivo and the aim was to identify the transcriptomic basis for this. Adaptation by fhs S. pneumoniae included upregulation of pathways involved in secondary metabolites biosynthesis and quorum sensing while the proABC S. pneumoniae was upregulated for carbohydrate metabolism pathways. In Chapters 6 and 7, the transcriptomic adaptations of S. pneumoniae serotype 1 and serotype 6B strains to altered iron and temperature levels were delineated respectively, indicating strain specific gene expression with the majority of differential regulation occurring in core pneumococcal genes. In Chapter 8, to pave the way for investigating the S. pneumoniae transcriptome in human samples, a challenge in pneumococcal research, an approach to directly isolate high-quality pneumococcal RNA from human carriers was developed. The work in this thesis provides new insights in the gene regulation of clinical S. pneumoniae strains under various environmental exposures
UND to host poet and spoken-word artist Tara Betts on Tuesday, Oct. 6
No full textThe University of North Dakota Writers Conference, in partnership with Multicultural Student Services, the Women’s Center, and the Black Students Association, is pleased to announce a special fall event.
Poet and spoken-word artist Tara Betts will read from her work at 4 p.m., on Tuesday, Oct. 6, in the Memorial Union River Valley Room. The event is free and open to the public.
Betts is the author of “Arc & Hue” and the chapbook/libretto THE GREATEST: An Homage to Muhammad Ali. Betts is a Cave Canem alumna, whose work has appeared in numerous publications, including Poetry magazine, The Break Beat Poets, Essence, Crab Orchard Review, Callaloo, and Ninth Letter, among others. Betts also appeared on HBO’s “Def Poetry Jam” and the Black Family Channel series “Spoken” with Jessica Care Moore. After winning Guild Complex’s Gwendolyn Brooks Open Mic Award, she represented Chicago twice at the National Poetry Slam. She also coached youth who participated in Brave New Voices and Chicago\u27s Louder Than a Bomb.
Betts encourages literacy and works with arts programs. In Chicago, she was an influential educator. Tara co-founded GirlSpeak, a weekly writing/leadership workshop for young women. She has also conducted short-term workshops in schools, community centers, Ms. Foundation, City Girls (a substance abuse rehabilitation center for teen girls), Cook County Jail and Cook County Juvenile Detention Center, Louder Arts Project, Cooper Union, Dodge Foundation’s Poets-In-The-Schools program, London’s Roundhouse, and the Binghamton Poetry Project. She holds a Ph.D. in English from Binghamton University and a Master of Fine Arts in Creative Writing from New England College
Untitled
No full textThe Burnett Archive of Working Class Autobiographies was gathered together by John Burnett, David Vincent and David Mayall whilst compiling their three volumes annotated bibliography, "The Autobiography of the Working Class" (Harvester Press, 1984-1989). This book includes descriptions of unpublished autobiographies and indicates their locations. Excerpts from some of the autobiographies have been published in "Destiny obscure: autobiographies of childhood, education, and family from the1820s to the 1920s", edited by John Burnett (Routledge 1994 and A. Lane, 1982). The authors "sought to identify not only the large numbers of printed works scattered in various local history libraries and record offices, but also extant private memoirs, many of which remain hidden in family attics, known only to the author and a handful of relatives" (Introduction to vol.1, p. xxix). The criteria for inclusion were: the writers were working class for at least part of their lives; they wrote in English; and they lived for some time in England, Scotland or Wales between 1790 and 1945. John Burnett was professor of social history at Brunel University from 1972 to 1990.Memories of Frank Betts, born 1885. Betts comments on leisure and workhouses as well as early motor cars
The people and the population: immigration and social cohesion
No full textWhat should be the criteria for expanding or limiting Australia’s population? Globalisation and relevance? Environmental concerns about the fragility of the natural setting? The market? Jobs? Cultural diversity and cohesion? Or all of the above? Barry Jones, author and former Labor ALP President and Member of Parliament; Meredith Hellicar, CEO of Corrs Chambers Westgarth; Dr Katharine Betts, Associate Professor, Social and Behavioural Sciences, Swinburne; and Kevin Andrew MP, Liberal Member for Menzies took up the issues in a wide ranging discussion at The Sydney Institute on Thursday 31 May 2001
Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7-9 year old rural Gambian children
No full textEarly life exposures are important predictors of adult disease risk. Although the underlying mechanisms are largely unknown, telomere maintenance may be involved. This study investigated the relationship between seasonal differences in parental exposures at time of conception and leukocyte telomere length (LTL) in their offspring. LTL was measured in two cohorts of children aged 2 yrs (N = 487) and 7-9 yrs (N = 218). The association between date of conception and LTL was examined using Fourier regression models, adjusted for age, sex, leukocyte cell composition, and other potential confounders. We observed an effect of season in the older children in all models [likelihood ratio test (LRT) χ²2 = 7.1, p = 0.03; fully adjusted model]. LTL was greatest in children conceived in September (in the rainy season), and smallest in those conceived in March (in the dry season), with an effect size (LTL peak-nadir) of 0.60 z-scores. No effect of season was evident in the younger children (LRT χ²2 = 0.87, p = 0.65). The different results obtained for the two cohorts may reflect a delayed effect of season of conception on postnatal telomere maintenance. Alternatively, they may be explained by unmeasured differences in early life exposures, or the increased telomere attrition rate during infancy.</p
Data from paper - 'Proxies for basement structure and its implications for Mesoproterozoic metallogenic provinces in the Gawler Craton' on Journal of Geophysical Research - Solid Earth. 2018/2019.
No full textThis file contains data related to the publication 'Proxies for basement structure and its implications for Mesoproterozoic metallogenic provinces in the Gawler Craton' on Journal of Geophysical Research - Solid Earth. 2018/2019.Authorship by J.G. Motta, P. G. Betts, C.R. Souza Filho, S. Thiel, S. Curtis, R. J. Armit Data made available by the corresponding author J. G. Motta ([email protected]).Please see text document within the compressed file for clarification.</div
I Remember piece on the author\u27s experience working with Dr. Richard Hornberge
No full textI Remember piece on the author\u27s experience working with Dr. Richard Hornberger of Waterville when the author was the doctor on call for a couple of Maine summer camps. Hornberger wrote short stories of his experiences as a surgeon in Korea, a book that eventually went into print as M.A.S.H
The two-legged stool: the neglected role of educational standards in improving America's public schools
No full textThe author notes that raising the school-leaving age and increasing the amount of spending per pupil have been extremely important public school reforms. However, he says, sizable improvements in school quality will only be evident when these two reforms are complemented by higher standards--and when students' abilities to meet these standards are tested.Education
AESC_LRFT_Blaikie_2016.pdf
No full textPresentation of new geophysical interpretation of the Leichhardt River Fault Trough, Mount Isa Inlier at the Australian Earth Science Convention (June 2016). The presentation was given by Peter Betts. The presentation is related to a paper that was submitted to the Journal Precambrian Research in May 2016. The first author of the paper is Dr Teagan Blaikie
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