97 research outputs found
Semantic Web Technologies for Digital Libraries: From Libraries to Social Semantic Digital Libraries (SSDL), Over Semantic Digital Libraries (SDL)
No full textDigital libraries have been an important source of information throughout the history of mankind. It has been present in our societies in different forms. Notably, traditional libraries have found their on the desktops of internet users. They have taken the shape of semantic digital libraries, which are accessible at any time, and accordingly provide a more meaningful search. This paper further discusses social semantic digital libraries that also incorporate the social and collaborative aspect
Mycorrhized wheat and bean plants tolerate bismuth contaminated soil via improved metal detoxification and antioxidant defense systems
No full texthttp://dx.doi.org/10.13039/501100004242 Princess Nourah Bint Abdulrahman Universit
Corrigendum to ‘Long acting anti-infection constructs on titanium [Journal of Controlled Release 326 (2020) 91–105]’ (Journal of Controlled Release (2020) 326 (91–105), (S0168365920303473), (10.1016/j.jconrel.2020.06.013))
No full textThe authors regret that the affiliation for the author Hadil Faris Alotaibi was incorrect in the published paper stating they were associated with both a and c. The correct affiliation is c Department of Pharmaceutical Sciences, Pharmacy college, Princess Nourah bint Abdulrahman University, Saudi Arabia The authors would like to apologise for any inconvenience caused. DOI of original article: https://doi.org/10.1016/j.jconrel.2020.06.01
Treatment planning study of cyberKnife prostate SBRT (stereotactic body radiation therapy) using CT-based vs MRI-based prostate volumes
No full textThis study has been conducted for the purpose of investigating the systematic dose reduction of rectum and neurovascular bundles (NVBs) during treatment planning of the CyberKnifeTM prostate SBRT using CT-Based volumes versus MRI-based volumes. Three prostate cancer patients were Planned for the CyberKnifeTM prostate SBRT and they underwent computed tomography (CT) and magnetic resonance imaging (MRI) preplanning exams. The patients were positioned during both exams using an immobilizing device. A radiation oncologist and a radiologist delineated the prostate gland, intra-prostatic and peri-prostatic structures, and pelvic organs of interest in both CT and MRI images. The CT and MRI images were fused based on fuducial markers to accurately align the prostate. Radiation Therapy Oncology protocol RTOG 0938 was followed to meet the target volume (prostate plus margin) dose coverage requirement, and dose-volume constraints for organs at risk, including rectum, bladder, femoral heads, penile bulb, urethra, skin and NVBs. Radiation dose volume parameters were recorded for both volumes and compared. The preliminary result shows that the CT-based volumes were generally larger than MRI-based volumes of the prostate. Therefore, the CT-based volumes resulted in less accurate treatment planning and dose delivery to radiosensitive structures
Optimizing the planning of building renovation projects
No full textSubmission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01The student, Mansour Alotaibi, accepted the attached license on 2021-11-25 at 23:05.The student, Mansour Alotaibi, submitted this Dissertation for approval on 2021-11-25 at 23:14.This Dissertation was approved for publication on 2021-11-30 at 09:03.DSpace SAF Submission Ingestion Package generated from Vireo submission #17271 on 2022-04-29 at 16:10:01Made available in DSpace on 2022-04-29T21:58:27Z (GMT). No. of bitstreams: 2
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemAuthor requested closed access (OA after 2yrs) in Vireo ETD systemLimitedA large number of the buildings in the United States are aging and in urgent need of renovation to improve their operational, economic, social, and environmental performance. To address this, building renovation projects in the United States have been increasing in recent years. A significant volume of this building renovation work focuses on leased buildings and hotel properties as they represent a substantial percentage of all existing buildings. This type of building renovation projects presents planners with significant challenges because they need to consider and minimize the disruptive impact of renovation activities on building operations and revenues during the planned work.
The main goal of this study is to present the development of novel models for optimizing the planning of building renovation projects that are capable of analyzing and minimizing the disruptive impact of renovation activities on the revenues of leased buildings and hotels. To achieve this goal, the research objectives of this study are to develop: (1) a novel model for optimizing the planning of leased building renovation projects that enables building owners to minimize total renovation cost including rental income losses; (2) an innovative model for optimizing the planning of renovation work in leased buildings that enables contractors working under Integrated Project Delivery method to maximize their reward sharing while minimizing total renovation cost; and (3) a novel model for optimizing the planning of hotel renovation projects that enables hotel owners to maximize their revenues during renovation work while minimizing project cost. The performance of the developed models was analyzed using real-life case studies. The results of this analysis illustrated the novel and unique capabilities of the developed models to (i) generate feasible renovation plans that fully comply with all practical constraints including the availability dates of leased units and hotel floors, (ii) quantify and minimize revenue losses of leased buildings and hotels during renovation work, (iii) reduce total renovation cost, and (iv) maximize net profits of both owners and contractors
RETRACTED: Alotaibi et al. Morpho-Physiological and Proteomic Analyses of Eucalyptus camaldulensis as a Bioremediator in Copper-Polluted Soil in Saudi Arabia. Plants 2019, 8, 43
No full textThe Plants Editorial Office has been made aware that there are partly inadequate materials in the published paper [...
Genetic Variation of Harmal (Peganum Harmala L. and Rhazya Stricta Decne) Based on Polymorphism in Protein Profile, Soil Analysis and Internode Anatomy
No full textThe vernacular name 'harmal' is applied to Peganum harmala L. and another noxious weed Rhazya stricta Decne. The study aimed to clarify the genetic relationships among different populations of harmal by employing ecological, anatomical characters and a pattern of leaf protein analysis. The soil and plant samples were collected from three regions of Saudi Arabia for each species. Soil texture of the harmal populations was characterized by loamy sand and sandy. Soil type had a significant effect on the internode anatomical characters of the soil textures of both hamal populations. The anatomical characters were observed in the cuticle layer on the stem. Similarly, compact epidermis, wide cortex and many water storing tissues were observed. In the present study, it was also observed that plants have numerous cortical cells to store large amount of water, so as to fight against the dry environment. This interaction between the soil type and the plant anatomical characters was found to be well adapted to the environment of different habitats. The sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE) analysis of pattern profiles showed limited variations between the two species of harmal, which indicated the genetic similarity among populations of both species at different habitats. These variations were considered as successful adaptations leading to tolerance
Morpho-Physiological and Proteomic Analyses of <i>Eucalyptus camaldulensis</i> as a Bioremediator in Copper-Polluted Soil in Saudi Arabia
No full textThe present investigation aimed to assess the impact of copper (Cu) stress on the physiological and proteomic behavior of Eucalyptus camaldulensis. E. camaldulensis is likely a potential phytoremediator in areas vulnerable to Cu contamination, such as the industrial areas of Riyadh. To realize this objective, young seedlings of E. camaldulensis were potted in an open area with soil comprised of clay and sand. Different doses of Cu (30, 50, and 100 µM) were applied to the plants as CuSO4·5H2O for 6 weeks. Plant growth was monitored during the Cu exposure period, and morphological and physiological indicators were measured once a week to determine the growth rates. A proteomics study was also conducted to find out the influence of Cu stress on proteins. Our results showed that growth was negatively affected by Cu treatment, particularly at the highest concentrations. Moreover, using a proteomic analysis showed 26 targets involved in protein expression. Elevated levels of Cu increased the expression of 11 proteins and decreased the expression of 15 proteins. Changes were detected in proteins involved in photosynthesis, translation, transcription, metabolism, and antioxidant enzymes. Our findings provided insights into the molecular mechanisms related to Cu stress, in addition to its influence on the morphological and physiological attributes of E. camaldulensis seedlings. This investigation aimed to characterize the mechanism behind the impact of Cu stress on the plant
Generalized multiscale finite element methods for the reduced model of darcy flow in fractured porous media
No full textIn this work, we combine the generalized multiscale finite element method (GMsFEM) with a reduced model based on the discrete fracture model (DFM) to resolve the difficulties of simulating flow in fractured porous media while efficiently and accurately reducing the computational complexity resulting from resolving the fine scale effects of the fractures. The geometrical structure of the fractures is discretely resolved within the model using the DFM. The advantage of using GMsFEM is to represent the fracture effects on a coarse grid via multiscale basis functions constructed using local spectral problems. Solving local problems leads to consideration and usage of small scale information in each coarse grid. Besides, the multiscale basis functions, generated following GMsFEM framework, are parameter independent and constructed once in what we call offline stage. These basis functions can be re-used for solving the problem for any input parameter when it is needed. Combining GMsFEM and DFM has been introduced in other works assuming continuous pressure across the fractures interface. This continuity is obtained when the fractures are much more permeable than that in the matrix domain. In this work, we consider a general case for the permeability in both fracture and matrix domain using the reduced model presented in Martin et al. (2005). The proposed reduction technique has significant impact on enabling engineers and scientist to efficiently, accurately and inexpensively solve the large and complex system resulted from modeling flow in fractured porous mediaThe first author Manal Alotaibi would like to acknowledge the support provided by the Department of Mathematics at King Fahd University of Petroleum & Minerals (KFUPM) under Start-up Research Grant number . The work of Huangxin Chen was supported by the NSF of China (Grant No. 12122115, 11771363)The work of Shuyu Sun was supported by King Abdullah University of Science and Technology (KAUST) through the grants BAS/1/1351-01, URF/1/4074-01, and URF/1/3769-0
Biallelic ELOVL1 Variants Are Linked to Hypomyelinating Leukodystrophy, Movement Disorder, and Ichthyosis
No full textAbstract Background Very long chain fatty acids (VLCFAs) are an integral component of myelin and the epidermal water barrier. Variants in genes encoding enzymes responsible for catalyzing the first and rate limiting step in the production of VLCFAs, elongation of VLCFAs (ELOVLs), underlie a novel group of metabolic disorders. Objectives The goal was to describe the clinical phenotype and disturbance in VLCFA metabolism associated with variants in the ELOV1 gene. Methods The following methods were employed: Exome sequencing, clinical phenotyping, magnetic resonance imaging (MRI), metabolomics, liquid chromatography–tandem mass spectrometry, fatty acid elongation assay. Results We, here, describe seven patients with autosomal recessive variants in ELOVL1 . Common clinical features included ichthyosis (5/7), developmental delay (7/7), progressive spasticity (7/7), nystagmus (5/6), and a complex movement disorder characterized by pronounced head tremor (7/7), myoclonus (6/7), and dysarthria (6/6). Brain MRI revealed non‐progressive hypomyelination (6/6) and hypoplasia of the corpus callosum (5/6). Plasma VLCFA analysis in one patient showed reduced concentrations of C24:0 and C26:0. Biochemical analysis of fibroblasts from this patient revealed elongation defects in VLCFA synthesis and dysregulation of other ELOVL enzymes. Conclusions We show that biallelic variants in ELOVL1 are associated with a unique and recognizable phenotype of hypomyelinating leukodystrophy, ichthyosis, and a complex movement disorder including progressive spasticity, head tremor, and myoclonus. Biochemical analyses confirmed a defect in VLCFA synthesis. Variants in genes encoding enzymes involved in the elongation of VLCFAs are a novel group of metabolic disorders with overlapping symptoms. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
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