2,395 research outputs found
Coronary artery disease: clinical presentation, diagnosis and prognosis in women.
No full textRecent advances in the field of cardiovascular medicine have not led to significant declines in case-fatality rates for women as in men. There are gender-specific differences in symptoms profile, diagnosis and treatment of coronary disease in women. For women presenting for coronary heart disease (CHD) evaluation, traditional disease management approaches that focus on detection of a 'critical stenosis' often fail to identify those women critically at-risk. Symptoms do not help physicians in differential diagnosis of chest pain in women; indeed the most common presentation of obstructive CHD in women is atypical symptoms. In 50% of the cases, non-obstructive CHD at coronary angiography, due to 'noncardiac chest pain' or coronary microvascular dysfunction is frequently reported. For these reasons, the evidence reviewed suggests that prognostic risk assessment may work relatively better than diagnostic obstructive coronary disease assessment for women
Hemodynamic modification induced by left bundle branch block
No full textHemodynamic modification induced by left bundle branch bloc
The Rise of A District Lead Firm: The Case of Wam (1968-2003)
No full textIn recent years a major evolution in several industrial districts in Italy has been the emergence of new hierarchical structures that led to the rise of lead firms. These are firms that - contrary to canonical district firms which tend to remain small - pursue size growth, invest in marketing, distribution and R&D, reorganize their subcontracting networks, and become international by establishing commercial subsidiaries and prodcution facilities abroad. However, despite their increasing importance, lead firms' histories remain largely unexplored. This paper contributes to fill this gap by examining the case of one of such lead firms: Wam, a company set up in 1968 in the mechanical engineering district of Modena, which at the beginning of the 21st century had become the world leader in the production of bulk material handling and dust filtration machinery. This paper in particular focuses on the strategy of growth and internationalization that this company has pursued and its effects in both the host nations and in its Italian ID of origin.Italy; Industrial Districts; Lead firms; Internationalization.
Calcificazioni coronariche nei pazienti affetti da diabete mellito
No full textThe use of noninvasive imaging techniques like electron beam and multislice computed tomography, to measure coronary artery calcium, is becoming increasingly accepted for risk stratification in both symptomatic and asymptomatic populations. The National Cholesterol Education Panel guidelines indicate that measurement of coronary calcium is an option for advanced risk assessment in appropriately selected persons. Because of the recognized high risk for cardiovascular events in patients with diabetes, they belong to the same high-risk category previously reserved for patients with known coronary heart disease. Diabetic patients might benefit from risk stratification with these noninvasive techniques. Indeed, absence of coronary calcium might indicate a low risk for events, while the presence of moderate to high calcium scores may help physicians to better gauge the intensity of medical therapy provided to their patients
Dimensioni culturali del benessere del bambino
No full textIl contributo riporta gli esiti di una ricerca di campo svolta in alcuni asili nido di Bologna, Cervia-Ravenna, Modena riguardante gli stili di cura e educativi differenti che abitano contesti sempre più multiculturali. La ricerca si è basata su colloqui con i genitori (sopratutto madri) di famiglie migranti iscritte ai servizi nido mettendone a fuoco le pratiche di cura
A novel mtDNA point mutation in tRNAVal is associated with hypertrophic cardiomyopathy and MELAS
No full textBackground. Pathological mutations of mitochondrial (mt) DNA may cause specific diseases such as cardiomyopathies or hearing loss, or syndromes such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome. We describe a novel mtDNA mutation in a patient with severe hypertrophic cardiomyopathy associated with MELAS. The familial phenotype included 1) hypertrophic cardiomyopathy and MELAS, 2) clinically mild cardiac hypertrophy, and 3) deafness. Methods. The proband and her first degree relatives underwent echo and electrocardiograms, and biochemical tests. Magnetic resonance imaging of the brain was performed in the proband. mtDNA was fully analyzed by sequencing. DNA purification, polymerase chain reaction and direct automated sequencing were performed following standard procedures. Heteroplasmy of the novel mutation was quantified by densitometric analysis. Results. A novel G1644A transition affecting the tRNAVal was identified in the proband and maternal relatives. The mutation has been interpreted as pathological because the G at the 1644 position is a highly conserved base, is heteroplasmic with higher levels of mutant DNA in the proband than in the relatives, is located in the unique tRNAVal, is very close to a mutation described as causative of MELAS, and finally has not been found in 100 healthy controls. Conclusions. Although it is rare for patients with MELAS to be referred to cardiological evaluation because of coexisting cardiomyopathy, cardiologists should be aware of this association as well as of the non cardiac signs that may address the diagnosis to mtDNA defect-related disease in families with a variable phenotype. © 2004 CEPI Srl
Fluoride-containing nanoporous calcium-silicate MTA cements for endodontics and oral surgery: Early fluorapatite formation in a phosphate-containing solution
No full textGandolfi MG, Taddei P, Siboni F, Modena E, Ginebra
MP, Prati C. Fluoride-containing nanoporous calcium-silicate
MTA cements for endodontics and oral surgery: early fluorapatite
formation in a phosphate-containing solution. International
Endodontic Journal, 44, 938–949, 2011.
Aim To test the chemical–physical properties and
apatite-forming ability of experimental fluoride-doped
calcium silicate cements designed to create novel
bioactive materials for use in endodontics and oral
surgery.
Methodology A thermally treated calcium silicate
cement (wTC) containing CaCl2 5%wt was modified by
adding NaF 1%wt (FTC) or 10%wt (F10TC). Cements
were analysed by environmental scanning electron
microscopy with energy-dispersive X-ray analysis, IR
and micro-Raman spectroscopy in wet conditions
immediately after preparation or after ageing in a
phosphate-containing solution (Dulbecco’s phosphatebuffered
saline). Calcium and fluoride release and pH of
the storage solution were measured. The results
obtained were analysed statistically (Tukey’s HSD test
and two-way anova).
Results The formation of calcium phosphate precipitates
(spherulites) was observed on the surface of
24 h-aged cements and the formation of a thick
bone-like B-type carbonated apatite layer (biocoating)
on 28 day-aged cements. The rate of apatite formation
was FTC > F10TC > wTC. Fluorapatite was
detected on FTC and F10TC after 1 day of ageing,
with a higher fluoride content on F10TC. All the
cements released calcium ions. At 5 and 24 h, the
wTC had the significantly highest calcium release
(P < 0.001) that decreased significantly over the
storage time. At 3–28 days, FTC and F10TC had
significantly higher calcium release than wTC
(P < 0.05). The F10TC had the significantly highest
fluoride release at all times (P < 0.01) that decreased
significantly over storage time. No significant differences
were observed between FTC and wTC. All the
cements had a strong alkalinizing activity (OH)
release) that remained after 28 days of storage.
Conclusions The addition of sodium fluoride accelerated
apatite formation on calcium silicate cements.
Fluoride-doped calcium silicate cements had higher
bioactivity and earlier formation of fluorapatite. Sodium
fluoride may be introduced in the formulation of
mineral trioxide aggregate cements to enhance their
biological behaviour. F-doped calcium silicate cements
are promising bone cements for clinical endodontic use.Peer ReviewedPostprint (published version
Left atrium eclassified: application of the American Society of Echocardiography/European Society of Cardiology cutoffs to unselected outpatients referred to the echocardiography laboratory
No full textOBJECTIVES: We sought to determine whether categorization of abnormal left atrial (LA) size based on volumes indexed to body surface area (LAVi) results in reclassification of LA dilatation if the classic antero-posterior diameter (LAd) was measured. The American Society of Echocardiography/European Society of Cardiology recommended LAVi over linear measurements and recently published cutoffs to qualify LA dilatation. However, many laboratories continue to use the LAd because it appears easier to measure. METHODS: Unselected adult outpatients referred to the echocardiography laboratory for any indication in the period March 2005 to January 2006 prospectively underwent standard Doppler echocardiography, including real-time measurement of LAd and LAVi. RESULTS: We enrolled 578 patients (mean age 66 +/- 14 years, 56% women). There was a good positive linear correlation between LAd and LAVi (r = 0.686, P < .0001). When the published cutoffs for LA enlargement were used, 49.0% of patients were classified as having abnormal LA by LAd and 76.3% by LAVi (P < .001). Of the 295 who had normal LA by LAd, 58.6% patients had abnormal LAVi. Conversely, of the 283 with abnormal LAd, almost all patients (94.7%) had abnormal LAVi. The proportion of overall agreement was 67.5% (kappa = 0.357, P < .001). CONCLUSION: Assessment of LA size by LAVi allows identification of patients with enlarged atria that would have been missed if classified by antero-posterior diameters, especially when cutoffs are applie
Detection of localized chronic type A aortic dissection: a multimodality imaging approach.
No full textN
- …
