1,720,997 research outputs found
Regulation of basic fibroblast growth factor and nerve growth factor mRNA by beta-adrenergic receptor activation and adrenal steroids in rat central nervous system
No full textLa regolazione della sintesi del Nerve Growth factor nel Sistema Nervoso Centrale: gli steroidi come potenziali mediatori
No full text2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)-quinoxaline (NBQX) increases fibroblast growth factor mRNA levels after contusive spinal cord injury
No full textDifferential induction of nerve growth factor and basic fibroblast growth factor mRNA in neonatal and aged rat brain
No full textIn rats the reserpine induced increase of brain NGF biosynthesis is mediated by corticosteroids
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CCL5 activates a orphan G-protein coupled receptor 75 in human neuroblastoma SH-SY5Y cell line. 15-19 NOVEMBER, WASHINGTON DC
No full textThe chemokine CCL5 inhibits entry of M-tropic HIV strains into macrophages/microglia by affecting the binding of the envelop protein gp120 to the co-receptor CCR5. Interestingly, CCL5 also prevents neuronal cell death mediated by the T-tropic gp120 and the viral protein Tat, which have no affinity for CCR5. Thus, CCL5 could be used to reduce HIV-associated neurocognitive disorder (HAND). Nevertheless, the mechanism of action of CCL5 remains to be fully characterized. Recent studies have shown that CCL5 activates a G-protein coupled receptor 75 (GPR75) which encodes for a 540 amino-acid orphan receptor of the Gq α family. In the present study, we examined the interaction of CCL5 and GPR75 in neuroblastoma SH-SY5Y cells that do not express other receptors for CCL5, such as CCR5, CCR3, and CCR1. CCL5 then promoted GPR75 internalization within few minutes. In addition, CCL5 elicited a significant dose-dependent increase in pro-survival pathways, such as the phosphatidylinositol 3-kinase (PI3K) and the extracellular signal-regulated kinases (ERK1/2). Akt and ERK1/2 phosphorylation were blocked by the specific pathway inhibitors, Wortmannin and U73 122, respectively, but not by pertuxin toxin, suggesting that CCL5 activate a Gq-coupled receptor. In conclusion, we hypothesize that CCL5-GPR75 signaling could further activate a neuroprotective mechanism that could explain the multiple pro-survival roles of CCL5 in reducing gp120 and Tat cell death
Ontogenetic study of [3H]imipramine binding sites and serotonin uptake system: Indication of possible interdependence
No full textRegional and temporal pattern of expression of nerve growth factor and basic fibroblast growth factor mRNA in rat brain following electroconvulsive shock
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