653 research outputs found
Effects of Participatory and Physical Life Goals in a Preventive Care Program for Frail Community-Dwelling Older People: A Retrospective Cohort Study
No full textAbstract
Date Presented 3/31/2017
Life goals related to activities and participation had a more positive effect on frail older people’s health and quality of life than did life goals related to physical function and structure. The setting of meaningful goals may help to improve the effectiveness of preventive care programs.
Primary Author and Speaker: Yoshimi Yuri
Additional Authors and Speakers: Shinichi Takabatake, Yoko Tsuji, Yuri Fujii, Toshikatsu Kaneda, Yasuhiro Higashi, Hiroko Hashimoto, Kazuyo Nakaoka, Mari Oka</jats:p
Advanced water purification technology. Examples of water treatment plants, and the integrated experiment plant.
No full text
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression
No full text主査：岡田 斉 教授
学内授与番号：医第1425号This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Yasuhiro Masuta, Kosuke Minaga, Masayuki Kurimoto, Ikue Sekai, Akane Hara, Naoya Omaru, Natsuki Okai, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Sho Masaki, Ken Kamata, Hajime Honjo, Yasuyuki Arai, Kouhei Yamashita, Masatoshi Kudo, Tomohiro Watanabe "Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression" International Immunology, Volume 35, Issue 2, February 2023, Pages 79–94] is available online at: [https://doi.org/10.1093/intimm/dxac045]
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression
No full text近畿大学Kindai University博士（医学）主査：岡田 斉 教授
学内授与番号：医第1425号This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Yasuhiro Masuta, Kosuke Minaga, Masayuki Kurimoto, Ikue Sekai, Akane Hara, Naoya Omaru, Natsuki Okai, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Sho Masaki, Ken Kamata, Hajime Honjo, Yasuyuki Arai, Kouhei Yamashita, Masatoshi Kudo, Tomohiro Watanabe "Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression" International Immunology, Volume 35, Issue 2, February 2023, Pages 79–94] is available online at: [https://doi.org/10.1093/intimm/dxac045].doctoral thesi
Suspense in Philostratus' Apollonius
No full textThis paper aims to show the ways in which suspense works in Philostratus' Apollonius. The author tries to keep his narrative unsurprising by making use of the ‘basic narrative pattern', a template which guarantees Apollonius' victory over any rival character he meets during his worldwide travels. We repeatedly find the protagonist gaining an upper hand over other socially distinguished figures and, through that process, come to be able to keep ourselves calm in the face of whatever happens to the Tyanean sage. The established pattern also allows the author to arrange his episodes in any order he wants because whatever he tells us in a given episode, his goal is always the same --the winner is Apollonius. So basically we have no choice but to acknowledge that Apollonius' conversations, which cover a large part of the work, are predictable and that the whole narrative is quite loosely structured. We, however, have the two important exceptions: the Nero episode and the Domitian episode. In these episodes, we can find Philostratus taking special care of his narrative arrangement to make the episodes exciting to read. More precisely, the author offers us various kinds of suspense, by which he makes the reader uncertain of the future of the protagonist, who is confronted with Nero's and Domitian's threatening antipathy. Even though we can expect Apollonius' victory over the tyrants relying on the ‘basic narrative pattern', still we cannot easily dismiss the possibility of his subordination to them. From these observations, we can conclude that Philostratus is not always an unthinking cataloguer. At least in the two episodes that feature Apollonius' conflict with the ‘anti-philosophy' emperors, the author can be seen as a sophisticated storyteller who struggles to entertain his readers by carefully arranging narrative components
On lunar collision orbits: New methodologies for Moon-to-Moon transfer design
No full textMany interplanetary missions massively leverage the lunar gravitational pull in the so-called low-energy regime to converge to their aim, saving consistent amount of fuel. Among these, two future Japanese spacecraft are expected to repeatedly encounter the Moon along their trajectories to either facilitate the escape from the Earth–Moon system or opportunely target a specific region in its neighbourhood. Although never actively employed for preliminary trajectory design, lunar collision orbits have shown a rich dynamical structure and an applicability for both medium- and low-energy regimes. These characteristics, together with their intrinsic nature of being close to trajectories experiencing lunar fly-by, have encouraged this research. In this work, lunar collision orbits are employed to delineate a method for obtaining ballistic transfers between two successive lunar encounters, briefly addressed as Moon-to-Moon. This study is first carried out with the assumptions of the autonomous Circular Restricted Three-Body Problem, subsequently extended to the nonautonomous Bi-circular Restricted Four-Body Problem, including the solar gravitational influence.Poincaré cuts are extensively used as a dimensionality reductant for lunar collision orbits: this allows to ascertain their similar behaviour with trajectories flybying the Moon, whose characteristics are partly foreseen by determining the associated intersection with the same cut. A patching is performed at the cut to obtain both single and multiple ballistic Moon-to-Moon transfers. The strict bond of lunar collision orbits with the invariant manifolds of simple periodic orbits about Lagrangian points is confirmed and exploited to design ballistic itineraries connecting highly elliptic orbits about the Earth to horizontal Lyapunov orbits of the Earth–Moon system, via a single Moon-to-Moon transfer. With the usage of the lunar collision orbits and the Poincaré cut, a simple optimization technique is implemented to retrieve a properly defined Moon-to-Moon transfer from a trajectory missing a second fly-by with the Moon. Including the presence of the Sun, a similar method for obtaining single and multiple Moon-to-Moon transfers is developed. A classification of lunar double-collision transfers is then performed within the same framework, highlighting their similarity with other studies in past literature, eventually leading to the construction of a database of Moon-to-Moon transfers. The latter, conceived as an improvement with respect to the former version by adding the lunar gravitational influence, shows its applicability in real preliminary trajectory design.Aerospace Engineerin
Co-orbital motion and its application to JAXA's MMX mission
No full textIn the framework of JAXA's MMX mission to explore the Martian moon of Phobos, an analysis of the stability of three-dimensional quasi-satellite orbits in the Mars-Phobos circular restricted three-body problem was conducted. For this analysis, notions of co-orbital motion, interpreted as the slow motion of the guiding center of the trajectory along the disturbing potential of Phobos, were used. After identifying and analyzing different regions of stability for three quasi-satellite orbits at 100, 50 and 30 km from the center of Phobos, several conclusions were drawn regarding the dynamics of the ballistic escape of the spacecraft, interpreted in terms of co-orbital motion. By making use of these insights, a novel methodology to find periodic quasi-satellite orbits able to reach high latitudes over the surface of Phobos was derived. This methodology consists of two steps: a multi-objective minimization using co-orbital parameters as target functions, to isolate regions with potential periodic orbits; followed by a shooting algorithm to arrive at the final periodic orbit. As a result of this new methodology, two periodic orbits were found at 50 and 30 km from the center of Phobos, able to reach latitudes as high as 54 deg and 32 deg respectively. This result represents an important contribution to both the operations and the scientific return of the Phobos proximity phase within MMX.Aerospace Engineerin
Effects of atrial natriuretic Peptide after prolonged hypothermic storage of the isolated rat heart
No full textPrimary graft failure (PGF) caused by ischemia-reperfusion injury (IRI) is the strongest determinant of perioperative mortality after heart transplantation. Atrial natriuretic peptide (ANP) has been found to reduce the IRI of cardiomyocytes and may be beneficial in alleviating PGF after heart transplantation, although there is a lack of evidence to support this issue. The purpose of this study was to investigate the cardioprotective effects of ANP after prolonged hypothermic storage. For this purpose, an isolated working-heart rat model was used. After the preparation, the hearts were arrested with and stored in an extracellular-based cardioplegic solution at 3-4°C for 6 h and followed by 25 min of reperfusion. The hearts were divided into four groups (n = 7 in each group) according to the timing of ANP administration: Group 1 (in perfusate before storage), Group 2 (in cardioplegia), Group 3 (in reperfusate), and control (no administration of ANP). Left ventricular functional recovery and the incidence of ventricular fibrillation (VF) were compared. ANP administration at the time of reperfusion improved the percent recovery of left ventricular developed pressure (control, 45.5 ± 10.2; Group 1, 47.4 ± 8.8; Group 2, 45.3 ± 12 vs. Group 3, 76.3 ± 7; P < 0.05) and maximum first derivative of the left ventricular pressure (control, 47.9 ± 8.7; Group 1, 46.7 ± 8.8; Group 2, 49.6 ± 10.8 vs. Group 3, 76.6 ± 7.5; P < 0.05). The incidence of VF after reperfusion did not differ significantly among these four groups (71.4, 85.7, 57.1, and 85.7% in Groups 1, 2, 3, and control, respectively). This result suggests that the administration of ANP at the time of reperfusion may have the potential to decrease the incidence of PGF after heart transplantation
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