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Permanent alopecia after busulfan chemotherapy.
No full textSystemic chemotherapy is a well known cause of reversible hair loss. Busulfan chemotherapy, however, is responsible for a permanent alopecia that usually occurs in bone marrow transplant patients. We report two patients with permanent alopecia due to busulfan chemotherapy. Both patients had a diffuse alopecia characterized by greatly reduced hair density with short, thin hair. The pathology showed reduced follicular density in the absence of fibrosis, suggesting that alopecia may result either from hair follicle stem cell destruction or from acute damage to the keratinocytes of the lower portion of some follicles
Unusual presentation of porokeratotic lichen planus: Histology, dermoscopy and confocal microscopy imaging of a rare condition
Full text linkHistology, dermoscopy and confocal microscopy imaging of POROKERATOTIK LICHEN PLANU
Unusual inflammatory and hyperkeratotic halo naevus in children.
No full textAlthough the classic halo naevus (HN) is a melanocytic naevus with a surrounding
rim of depigmentation, these naevi can present unusual features. We describe an
unusual and previously unreported variety of HN in children. Between March 1999
and September 2002, 14 children (11 boys and three girls, age range 6-14 years)
were referred to us for evaluation of one or more 'inflamed' naevi. All the
affected naevi showed the same clinical development: (i) after an initial
inflammatory stage their surfaces gradually became thickened and rough, then
(ii) verrucous and raised, and finally (iii) scaly crusted. A marked halo of
depigmentation subsequently developed in all lesions, with simultaneous
disappearance of the hyperkeratotic surface appearance. Lesions were multiple in
five cases and single in nine, and were mainly located on the back (nine cases).
Excisional biopsy was performed in eight cases. The biopsies were all taken in
the 'prehalo phase'. In each case, histopathology revealed a compound
melanocytic naevus, with additional features that varied depending on the
clinical stage of the lesion. Immunohistochemical staining of the dense
inflammatory infiltrate showed a predominance of CD3(+)/CD8(+) T lymphocytes, as
usually occurs in HN. On the basis of these observations, we believe that the
described naevi represent an unusual variety of HN in children. Knowledge of
this possible clinical evolution of HN is important to avoid unnecessary
surgical excision in these young patients
Acquired progressive kinking of the hair. Clinical features, pathological study, and follow-up of 7 patients
No full textBackground: Acquired progressive kinking of the hair (APKH) is a relatively rare condition, with fewer than 20 cases reported in the literature. Whether APKH is a separate entity or a variety of androgenetic alopecia is still controversial. This study reviews the clinical and pathological features and long-term follow-up of 7 patients with APKH. Observations: Since January 1989, we have diagnosed APKH in 7 males aged 15 to 22 years. All patients had strong family history for androgenetic alopecia. Hair kinking affected the frontotemporal region and/or the vertex where the hair appeared curly, frizzy, and lusterless. The pathological features of the affected scalp were consistent with the diagnosis of the early stages of androgenetic alopecia. In all patients, APKH evolved into androgenetic alopecia during the follow-up period. Mean follow-up was 4.5 years (range, 2-9 years). Treatment with topical minoxidil did not prevent development of hair-thinning in the scalp areas affected by hair kinking. Conclusions: The term acquired progressive kinking of the hair encompasses a number of conditions characterized by acquired curling of the scalp hair. Acquired hair kinking on the androgen-dependent areas of the scalp represents a modality of onset of androgenetic alopecia associated with poor prognosis
Should idiopathic facial aseptic granuloma be considered granulomatous rosacea? Report of three pediatric cases.
Full text linkIdiopathic facial aseptic granuloma (IFAG), or pyodermite froide du visage, is a skin disease reported only in children and characterized by painless red nodules usually located on the cheeks. Its etiology is still unclear, but some authors considered the possibility that IFAG might be included in the spectrum of granulomatous rosacea (GR). The histopathological features of IFAG and GR are quite similar, showing perifolliculitis, granulomas, folliculitis, and lymphocytes and plasmacells around epithelioid histiocytes. In the present article, we discuss three cases in which an association between a facial nodule, compatible with both IFAG and GR, and recurrent chalazia make us support the hypothesis that IFAG should be considered as GR
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