1,721,065 research outputs found
The variegated histopathological features of atypical lentiginous melanocytic nevi (ALMNs): a single institution experience
No full textBACKGROUND:
Atypical lentiginous melanocytic nevi (ALMNs) are atypical pigmented lesions with histopathological features similar to those of dysplastic nevi, with a lentiginous pattern. Variable histopathological features of ALMNs were observed in our practice.
METHODS:
We described the histopathological features of ALMNs diagnosed in the period 2009- 2015. Our cases were divided into 2 groups: Group 1: ALMNs showing the same histopathological features as previously described in the literature; Group 2: ALMNs with different features.
RESULTS:
29 ALMNs were diagnosed. 2 groups of ALMNs were identified. Group 1 ALMNs showed a constant, mild epidermal acanthosis; frequently, an inflammatory infiltrate and dermal fibrosis, cytological atypia and mild architectural atypia. Group 2 ALMNs showed a constant psoriasis-like acanthosis with a hypercellularity of the rete ridges; cytological atypia was rare, whereas architectural atypia was constantly observed. Immunohistochemistry (MART-1 staining) revealed that the melanocytes were localized at the dermo-epidermal junction in both groups. ALMNs showed a broad spectrum of histopathological features.
CONCLUSIONS:
Our main finding was a constant architectural atypia in all lesions of Group 2. The identification of a unique type of ALMN seems no longer possible. The correct recognition of such benign, though atypical, melanocytic lesions is important in order to avoid an overdiagnosis of cutaneous melanoma and to prevent their potential evolution to the latter
Pseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype
No full text: Pseudolipoblastic perineurioma is a very uncommon variant of extraneural perineurioma, with only a limited number of cases documented in the medical literature. The most remarkable histopathologic characteristic is the existence of vacuolated cells that closely resemble lipoblasts; besides the presence of small, spindle shaped, or epithelioid perineurial cells. In this study, we present another case of pseudolipoblastic perineurioma, predominantly characterized by the presence of vacuolated "pseudolipoblastic" cells. The immunohistochemical expression of EMA, Glut-1, claudin-1, collagen type IV, and laminin as well as S-100 negativity is essential for the diagnosis to support the perineurial origin. Simple excision is the best treatment option for these benign tumors that do not recur or metastasize. It is crucial to recognize this rare entity to differentiate it from many other tumors characterized by prominent intracytoplasmic vacuoles
An asymptomatic subungual nodule
Full text link.an asymptomaric subungual nodule should always be biopsie
Wounds resulting from intradermal injection of sodium hypochlorite: a case report
No full textBackground: Caustic substances can inflict severe damage on tissues upon contact. Knowledge about skin damage caused by sodium hypochlorite is quite limited, with only a few reports available in the literature. Case report: A 79-year-old female with severe cognitive decline presented with multiple skin ulcerations that were covered by a blackish-greyish eschar and surrounded by a purple erythematous halo. During the medical examination, in a moment of clarity the patient confessed to self-inflicting the wounds through injections of bleach at night. Analysis of the liquid beneath the eschar from the ulcer swab and the histological examination confirmed the compatibility of lesions with the injection of sodium hypochlorite. Conclusion: Intradermal injection of sodium hypochlorite can cause severe damage to the skin tissue, with rapid formation of ulcerations covered by a blackish-greyish eschar. The surrounding skin may have an erythematous, swollen appearance and a purple-colored halo around it. Moreover, for a patient with a neuropsychiatric medical history, negative laboratory findings, or irregular skin lesions, self-induced ulcerations should always be considered in the differential diagnosis
Erythrodermic Leukemia Cutis in Patient with Myelodysplastic Syndrome with Multilineage Dysplasia
Full text linkMohs Surgery for Squamous Cell Carcinoma of the Nail Unit: 10 Years of Experience
No full textSquamous cell carcinoma (SCC) is the most frequent malignant tumor of the nail unit
A Case of Acute Contact Dermatitis Caused by Lidocaine/Prilocaine Cream on a Zoon Balanitis
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