97 research outputs found
Optimal channel reuse in cellular radio systems with multiple correlated log-normal interferers
No full textPropensity score-matched analysis of long-term outcomes for living kidney donation in alternative complement pathway diseases: A pilot study
No full textBackground Atypical hemolytic syndrome (aHUS) and C3 glomerulopathy (C3G) are complement-mediated rare diseases with excessive activation of the alternative pathway. Data to guide the evaluation of living-donor candidates for aHUS and C3G are very limited. The outcomes of living donors to recipients with aHUS and C3G (Complement disease-living donor group) were compared with a control group to improve our understanding of the clinical course and outcomes of living donation in this context.Methods Complement disease-living donor group [n = 28; aHUS(53.6%), C3G(46.4%)] and propensity score-matched control-living donor group (n = 28) were retrospectively identified from 4 centers (2003-2021) and followed for major cardiac events (MACE), de novo hypertension, thrombotic microangiopathy (TMA), cancer, death, estimated glomerular filtration rate (eGFR) and proteinuria after donation.Results None of the donors for recipients with complement-related kidney diseases experienced MACE or TMA whereas two donors in the control group developed MACE (7.1%) after 8 (IQR, 2.6-12.8) years (p = 0.15). New-onset hypertension was similar between complement disease and control donor groups (21.4% vs 25%, respectively, p = 0.75). There were no differences between study groups regarding last eGFR and proteinuria levels (p = 0.11 and p = 0.70, respectively). One related donor for a recipient with complement-related kidney disease developed gastric cancer and another related donor developed a brain tumor and died in the 4th year after donation (2, 7.1% vs none, p = 0.15). No recipient had donor-specific human leukocyte antigen antibodies at the time of transplantation. Median follow-up period of transplant recipients was 5 years (IQR, 3-7). Eleven (39.3%) recipients [aHUS (n = 3) and C3G (n = 8)] lost their allografts during the follow-up period. Causes of allograft loss were chronic antibody-mediated rejection in 6 recipients and recurrence of C3G in 5. Last serum creatinine and last eGFR of the remaining patients on follow up were 1.03 +/- 038 mg/dL and 73.2 +/- 19.9 m/min/1.73 m2 for aHUS patients and 1.30 +/- 0.23 mg/dL and 56.4 +/- 5.5 m/min/1.73 m2 for C3G patients.Conclusion The present study highlights the importance and complexity of living related-donor kidney transplant for patients with complement-related kidney disorders and motivates the need for further research to determine the optimal risk -assessment for living donor candidates to recipients with aHUS and C3G
Effects of Correlated Interferers in Multi-User Radio Systems
No full textElectrical Engineering, Mathematics and Computer Scienc
Snca-GFP Knock-In Mice Allows Tracking the Endogenous alpha-Synuclein in Action
No full textNon peer reviewe
Variability of bed drag on cohesive beds under wave action
No full text© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Water 8 (2016): 131, doi:10.3390/w8040131.Drag force at the bed acting on water flow is a major control on water circulation and sediment transport. Bed drag has been thoroughly studied in sandy waters, but less so in muddy coastal waters. The variation of bed drag on a muddy shelf is investigated here using field observations of currents, waves, and sediment concentration collected during moderate wind and wave events. To estimate bottom shear stress and the bed drag coefficient, an indirect empirical method of logarithmic fitting to current velocity profiles (log-law), a bottom boundary layer model for combined wave-current flow, and a direct method that uses turbulent fluctuations of velocity are used. The overestimation by the log-law is significantly reduced by taking turbulence suppression due to sediment-induced stratification into account. The best agreement between the model and the direct estimates is obtained by using a hydraulic roughness of 10 m in the model. Direct estimate of bed drag on the muddy bed is found to have a decreasing trend with increasing current speed, and is estimated to be around 0.0025 in conditions where wave-induced flow is relatively weak. Bed drag shows an increase (up to fourfold) with increasing wave energy. These findings can be used to test the bed drag parameterizations in hydrodynamic and sediment transport models and the skills of these models in predicting flows in muddy environments.This research was supported by the Office of Naval Research funding of contracts N00014-07-1-0448, N00014-07-1-0756
Impact behavior of model porous concretes
No full textIn this work, findings of a numerical study performed to investigate the impact behavior of porous concrete, modeled as a four phase cementitious composite consisting of aggregates, cement paste, interfacial transition zones (ITZ) and air, are presented. The numerical analyses contributed to the process of designing a special type of concrete for safety purposes i.e. as a protective building material to be used in safety walls outside important buildings or munition magazines for storing explosives. In case of an explosion, large concrete fragments that are formed, cause a very important threat. Therefore, in the scope of a research project, designing a special type of concrete having sufficient strength, but fracturing into small fragments under impact loading was aimed. In the numerical analyses, model porous concretes, in which the amounts and properties of pores and aggregates could be varied individually, were used to see the sole effect of each parameter. According to the results, it was found that at constant total porosity, the impact strength increased with decreasing pore size while multiple fragmentation was observed. On the other hand, the impact strengths of porous concretes with different size aggregates (with constant total aggregate content and porosity) were approximately the same when no ITZ was defined. However, when ITZ was present, the impact strength was found to decrease as the aggregates were finer. This trend was also valid for the respective full concretes. Representative experimental results of porous concretes were also presented in order to support the numerical results.Accepted Author ManuscriptApplied MechanicsMaterials and Environmen
GENOTYPING FOR PERSONALIZED MEDICINE IN ADULT PATIENTS WITH PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS
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