27 research outputs found
The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease
No full textAlzheimer’s disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues and mortality among older individuals. This condition involves a progressive deterioration in cognitive function and the onset of dementia. Recent advancements suggest that the development of AD is more intricate than its underlying brain abnormalities alone. In addition, Alzheimer’s disease, metabolic syndrome, and oxidative stress are all intricately linked to one another. Increased concentrations of circulating lipids and disturbances in glucose homeostasis contribute to the intensification of lipid oxidation, leading to a gradual depletion of the body’s antioxidant defenses. This heightened oxidative metabolism adversely impacts cell integrity, resulting in neuronal damage. Pathways commonly acknowledged as contributors to AD pathogenesis include alterations in synaptic plasticity, disorganization of neurons, and cell death. Abnormal metabolism of some membrane proteins is thought to cause the creation of amyloid (Aβ) oligomers, which are extremely hazardous to neurotransmission pathways, especially those involving acetylcholine. The interaction between Aβ oligomers and these neurotransmitter systems is thought to induce cellular dysfunction, an imbalance in neurotransmitter signaling, and, ultimately, the manifestation of neurological symptoms. Antioxidants have a significant impact on human health since they may improve the aging process by combating free radicals. Neurodegenerative diseases are currently incurable; however, they may be effectively managed. An appealing alternative is the utilization of natural antioxidants, such as polyphenols, through diet or dietary supplements, which offer numerous advantages. Within this framework, we have extensively examined the importance of oxidative stress in the advancement of Alzheimer’s disease, as well as the potential influence of antioxidants in mitigating its effects
ATTITUDE OF THE PEOPLE REGARDING WILDLIFE CONSERVATION, CAUSES OF HUMAN-WILDLIFE CONFLICT AND ITS MITIGATION MEASURES IN KASHMIR VALLEY
No full textThe present study was initiated to assess the attitude of local people living near the forests in ten (10) districts of Kashmir valley during the year 2016 -2018. The main aim was to assess the perception of people regarding wildlife conservation and general knowledge of local populace in this regard. It was also to know about Human-Wildlife conflict and the mitigation measures from the local point of view. About one thousand (1000) people belonging to the age group 18 to 76 years were questioned with hundred (100) from each district making sure each village of the districts belonging to all the five (5) wildlife divisions of Kashmir valley gets covered. population trend, 71% of the people were of the opinion that the population of the wild animal is increasing while the 19% of the people responded negative and 10% of population were not sure and gave no answer.An interesting find during the study was that Leopards and Wolves kill and consume the livestock, but the Black Bears go on silly rampage killing maximum and consuming minimum. About 47 % of the people from all the 10 districts held an opinion that sheep/goat were the cattle depredated most followed by cattle (cow, ox, buffalo etc.) about 31 % by Leopards and Black Bears and horsed around 14% by Leopards. Only 8% of the people reported others which included poultry, ducks and pets by Porcupines, Jackals and Foxes.Around 23% of the people guarding their fields using Dokas (Machans) said that this was by far the most effective method in keeping wild-animals away, 19% of the people are using watch dogs, 14% of the people are using the scare crows, 10% of the people were using wind chimes, around 11% that of the people were using methods of lighting fire as it is believed that fire has proved to be one of the best deterrent for wild animals
The Neuropharmacological Properties of Malkangni (Celastrus paniculatus Willd.): Insights from Unani Medicine and Pharmacological Research: A Review
No full textMalkangni, also known as Celastrus paniculatus Willd., is a herb widely used in the Unani system of medicine for its neuropharmacological properties. The seeds and oil of Malkangni have therapeutic benefits, including enhancing memory and cognitive functions. Malkangni exhibits a range of pharmacological activities, including neuroprotective, analgesic, anti-inflammatory, and antioxidant effects. It has shown potential to improve learning and memory, sedation, and anti-convulsive properties and treat conditions such as leprosy, rheumatism, diarrhea, and arthritis. The diverse pharmacological activities of Malkangni suggest its potential in treating various health conditions. This review aims to describe the medicinal properties and therapeutic applications of Malkangni through the perspective of Unani medicine and its phytochemical and pharmacological studies.
Keywords: Malkangni, Celastrus paniculatus, Unani medicine, traditional medicine, natural medicin
Alleviation of water and osmotic stress-induced changes in nitrogen metabolizing enzymes in Triticum aestivum L. cultivars by potassium
No full textREADING HABITS OF COLLEGE STUDENTS OF JAMMU & KASHMIR: A CASE STUDY OF DISTRICT ANANTNAG
No full textAbstract: Reading is an innate capacity of a person to relish the moral, cultural, social and political aspects of the life. It is the process where from one develops from being a child to a perfect man. The study sought to assess the reading habits of college students in district Anantnag. A questionnaire was used as a tool for data collection. The data collected was analyzed quantitatively and results are presented in tables and figures. From total copies of questionnaire distributed among the students of Science and Commerce departments, 303 were filled and were returned. The findings showed that majority of the respondents take reading seriously with 56.7% of the respondents reading for personality development. The paper also revealed that homes are the preferred destinations for study among students instead of libraries, advising us to create an attractive atmosphere and collection in libraries. The study revealed that newspapers and web pages are high in demand among college students. The study also revealed that parents are the main promoters of reading habits among college students
Preventive and Therapeutic values of Leech Therapy: A Review
No full textThere are three therapeutic modalities in the Unani medical system: Ilaj bit Tadbeer (Regimenal Therapy), Ilaj bid Dawa (pharmacotherapy), and Ilaj bil Yad (surgery). Ilaj bit Tadbeer includes several regimenal therapies such as Hijāma (Cupping Therapy), Ta\u27līq or Irsal-e-\u27Alaq (Leech Therapy), Fasd (Venesection), Dalk (Massage), Nutūl (Therapeutic Irrigation), Qai (Emesis), Idrār-i-Bawl (Diuresis), Tariq (Diaphoresis), Mundij wa Mu\u27shil therapy (Concoction and purgation), Bukhoor (Medicated Steam), Kaiyy (Cauterization), Huqna (Enema) etc. Since ancient times, these therapies have been widely used for their preventive, therapeutic, and rehabilitative effects. One of the most significant regimenal therapies, Irsal-e-Alaq (Leech therapy), is still in use. Renowned Unani physicians Razi, Majoosi, Zahrawi, and Ibne Sina have discussed and recommended the use of non-poisonous (or medicinal) leeches in the prevention and treatment of a variety of illnesses, including joint disorders, chronic non-healing ulcers, and numerous skin disorders like eczema, psoriasis etc. This review paper aims to explore the preventive and therapeutic role of leech therapy.
Keywords: Unani Medical System, Therapeutic Role, Leech Therap
High resolution inventory and hazard assessment of potentially dangerous glacial lakes in upper Jhelum basin, Kashmir Himalaya, India
No full textIn the Himalayan Mountain region, a large number of glacial lakes have developed in the recent past due to glacier recession under the influence of climate change. In this study, we used high resolution satellite data such as Indian Remote Sensing (IRS) LISS-IV (5.8 m) and Google earth images supplemented with field survey to generate an updated glacial lake inventory of Upper Jhelum Basin (UJB) of Kashmir Himalaya. The Sentinel-2A (10 m), Landsat-OLI (30 m) and MSS (60 m), and Cartosat-DEM (30 m) were additional data sources used for glacial lake mapping and change detection analysis. A total of 393 glacial lakes covering an area of 21.55 ± 3.8 km2 were identified, mapped and inventoried. The lake inventory includes 102 proglacial lakes, 13 supraglacial lakes and 278 unconnected glacial lakes. Using the weighted index-based method, 21 glacial lakes were found as Potentially Dangerous Glacial Lakes (PDGLs). Out of these, 7 lakes were classified as High, 9 as Medium and 5 as Low hazard glacial lakes as per the hazard assessment. Change detection analysis of PDGLs from 1980 to 2020 revealed an increase in area from 5.92 km2 to 8.46 km2 thereby, indicating a growth of 2.51 ±0.9 km2(30%) at a rate of 0.063 km2/year. The formation and growth of glacial lakes in this area is attributed to continuous glacier recession under the warming trend of temperature and declining nature of precipitation. In this study, the findings showed that Tavg and Tmin are rising significantly at a rate of 0.004ºC/year and 0.013ºC/year respectively. This study provides an important database for future GLOF studies in the region
Venesection (Fasd): Historical Insights and Modern Implications: A comprehensive review
No full textIlaj bit Tadbeer, a vital therapeutic approach in the Unani system of medicine, focuses on modifying six essential elements to restore health. This approach encompasses various regimenal therapies such as cupping (Hijāma), leeching (Ta\u27līq or irsal-e- \u27Alaq), venesection (Fasd), massage (Dalk), irrigation (Natūl), emesis (Qay\u27), diuresis (Idrār-i-Bawl), diaphoresis (Tariq), concoction and purgation (Mundij and Mu\u27shil therapy), medicated steam (Bukhoor), cauterization (Kaiyy), and enema (Huqna). Fasd is a crucial regimen in Ilaj Bit Tadbeer, serving as a method to eliminate morbid material from the body to treat diseases or maintain good health. With a history of almost 3000 years, Fasd has been effectively utilized in treating various ailments across different eras. Although venesection, or Fasd, has a historical significance, its modern application has declined due to the lack of scientific validation. This review aims to explore the historical context, therapeutic applications, contraindications, and contemporary scientific evidence of Fasd, emphasizing its potential in modern medicine.
Keywords: Ilaj bit Tadbeer, Unani medicine, Fasd, venesection, therapeutic applications, scientific evidence
Spatio-temporal analysis of glacial lakes from 1990 to 2018 in the Kashmir Himalaya, India using geospatial technology
No full textThe glacial lakes were identified, delineated, and mapped to observe changes in spatial extent using multi-date/multi-sensor remote sensing data and adequately supplemented by field studies. Landsat imageries were used to delineate the spatial extent of glacial lakes for four time points i.e., 1990, 2000, 2010 and 2018. The total count of lakes as well as their spatial extent showed a discernible increase. The number has increased from 253 in 1990 to 322 in 2018 with a growth rate of 21.4 percent. The area has increased from 18.84 Km2 in 1990 to 22.11 Km2 in 2018 with a growth rate of 14.7 percent. The newly formed glacial lakes including supra glacial lakes were greater in number than the lakes that have disappeared over the study period. All glacial lakes are situated at an elevation of 2700 m asl and 4500 m asl. More than 78 percent of lake expansion in the study region consists largely due to growth of existing glacial lakes. Through the area change analysis, our findings reveal that certain lakes show rapid expansion needing immediate monitoring and observation. In addition to climate variability, the presence of increasing quantities of light trapping particles could be possible causes for expanding of lakes in the Himalayas. Consequently, this study could play a significant role in devising a comprehensive risk assessment plan of potential GLOFs and develop a mechanism for continuous monitoring and management of lakes in the study region
