171,207 research outputs found
L'itinerario mitico della poesia di Michalis Pierìs, in C.Miglio, L. Canali (a cura di), Dossier geopoetica. Mappe di un'assenza/1
No full textLa sezione esplora la possibilità di una cartografia di testi poetici (Celan, commentato da C. Miglio; Milosz, commentato da L. Marinelli, Pierìs, commentato da P.M. Minucci; Darwish, commentato da S. Sibilio)
C. Kavafis
No full textSi traccia la storia della poesia di Kavafis dalle prime composizioni alle ultime, accettate e non. Si è data particolare attenzione all'evoluzione stilistica e strutturale della sua opera, dalle poesie evocative alla drammatizzazione del racconto poetico
Per una lettura critica della poesia “Makrià” di C. Kavafis
No full textAttraverso un'analisi e una lettura critica di uno dei testi poetici più evocativi di Kavafis, si cerca di definire la dinamica della memoria nella poetica kavafiana, individuando le costanti tematiche, lessicali e stilistiche che attraversano l'intera sua opera
Quella goccia d’Acqua in Più. Pianificazione e rischio idrogeologico
No full textPubblicazione composta da Libro degli Abstract (formato cartaceo) e Atti di Convegni su C
Giuseppe Poggi a Innocenzo Golfarelli, Felice Francolini, Ubaldino Peruzzi, Tommaso Minucci, Cesare Taruffi, Carlo Gabussi e a Luigi Marzu (9 aprile 1878)
No full textLettera di Giuseppe Poggi a Innocenzo Golfarelli, Felice Francolini, Ubaldino Peruzzi, Tommaso Minucci, Cesare Taruffi, Carlo Gabussi e a Luigi Marzucchi (9 aprile 1878)
Segnatura dell’unità documentale: Archivio storico dell’Accademia dei Georgofili, Carteggio amministrativo, Busta 47, 962.
Natura: manoscritto.
Consistenza: c. 1Digitalizzato come parte della Mostra virtuale: Ubaldino Peruzzi : un percorso in rete : in occasione del bicentenario della nascita https://www.georgofili.it/contenuti/ubaldino-peruzzi-un-percorso-in-rete/1748
Histone deacetylases and epigenetic therapies of hematological malignancies
No full textHistone deacetylase inhibitors (HDACi) represent a novel class of targeted drugs which alter the acetylation status of several cellular proteins. These agents, modulating both chromatin structure through histone acetylation, and the activity of several non-histone substrates, are at the same time able to determine changes in gene transcription and to induce a plethora of biological effects ranging from cell death induction, to differentiation, angiogenesis inhibition or modulation of immune responses. The impressive anticancer activity observed in both in vitro and in vivo cancer models, together with their preferential effect on cancer cells, have led to a huge effort into the identification and development of HDACi with different characteristics.To date, several clinical trials of HDACi conducted in solid tumors and hematological malignancies have shown a preferential clinical efficacy of these drugs in hematological malignancies, and in particular in cutaneous T-cell lymphoma (CTCL), peripheral T-cell lymphoma (PTCL), Hodgkin lymphoma (HL) and myeloid malignancies.Several agents are also beginning to be tested in combination therapies, either as chemo sensitizing agents in association with standard chemotherapy drugs or in combination with DNA methyltransferase inhibitors (DNMTi) in the context of the so-called " epigenetic therapies" , aimed to revert epigenetic alterations found in cancer cells. Herein, we will review HDACi data in hematological malignancies questioning the molecular basis of observed clinical responses, and highlighting some of the concerns raised on the use of these drugs for cancer therapy
Depression, burn out and suicidal ideation among Swedish and Italian Physicians (The HOUPE study)
No full textProgettare percezione e piena fruizione dei siti di interesse culturale da parte di persone con autismo
No full textAlthough there are no reliable data on the total number of people affected by autism spectrum disorders, recent estimates indicate that in Italy 1 child out of 77 is affected by these disorders, with a progressively increasing trend; the problem concerns about 500 thousand families and a total of 60 million people with DSA worldwide. Built environment full fruition for all is a key principle of the human right and international codes and standards about Cultural Heritage and Landscape state that promoting the knowledge of cultural heritage and ensuring the best conditions for its full enjoyment are central activities for the enhancement of cultural sites. Therefore cultural sites are actively called to offer adequate levels of accessibility, in physical and perceptive-cognitive terms, satisfying needs and requirements, expressed, implicit or special, of the widest range of vistors, regardless of temporary or permanent diversity and disability. On the basis of these premises, the paper proposes models of inclusive design for accessibility, use and physical, cognitive and emotional perception of cultural sites by people with autism, and presents two application cases of inclusive projects with “autism in mind” for a park and an archaeological museum, both in the province of Salerno (Campania, South Italy) In accordance with the testimonial value of the assets to be enhanced and based on users analysis, with the involvement of educators, architects and parents’ associations, the methodology was finalized to the redesign of full use conditions of the sites, both by persons with autism and for all visitors, focusing on material aspects (architectural and environmental dimension of access, orientation, seeing, listening, touching, stopping, etc.), as well as intangible aspects (educational and emotional dimensions)
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