2,147 research outputs found
Replication Data for: "Pharmacogenomics of opioid response in European advanced cancer patients"
No full textThis dataset contains the bioinformatic and statistical scripts developed and used to perform the genetic analyses described in my PhD thesis entitled “Pharmacogenomics of opioid response in European advanced cancer patients”, with the aim of ensuring transparency and reproducibility of this analytical workflow.
The scripts were applied to investigate inter-individual genetic variability in European advanced cancer patients to opioid treatment response, both in terms of efficacy, measured as Pain Intensity (PI) and treatment-related side effects, particularly nausea and vomiting, measured through a numerical Nausea-Vomiting Score (NVS).
Particularly, the scripts were used to perform genotype quality control, genome-wide association studies (GWAS), multivariable linear regression models, heritability estimation using LD Score Regression (LDSC), stratified LD Score Regression (sLDSC), colocalization analyses with eQTL data, and bidirectional Mendelian Randomization analyses.
The files provided are organized according to the analytical workflow described in the thesis and they are mainly written in Bash, R and Python language.
The file naming conventions reflect the order of the analysis and the phenotype investigated, to facilitate understanding by other researchers.
In compliance with the General Data Protection Regulation (GDPR), only analysis scripts are provided; no individual-level genetic or phenotypic data are included in this dataset
COVID-19 mortality in Italy varies by patient age, sex and pandemic wave
No full textSARS-CoV-2 has caused a worldwide epidemic of enormous proportions, which resulted in different mortality rates in different countries for unknown reasons. We analyzed factors associated with mortality using data from the Italian national database of more than 4 million SARS-CoV-2-positive cases diagnosed between January 2020 and July 2021, including > 415 thousand hospitalized for coronavirus disease-19 (COVID-19) and > 127 thousand deceased. For patients for whom age, sex and date of infection detection were available, we determined the impact of these variables on mortality 30 days after the date of diagnosis or hospitalization. Multivariable weighted Cox analysis showed that each of the analyzed variables independently affected COVID-19 mortality. Specifically, in the overall series, age was the main risk factor for mortality, with HR > 100 in the age groups older than 65 years compared with a reference group of 15-44 years. Male sex presented a two-fold higher risk of death than female sex. Patients infected after the first pandemic wave (i.e. after 30 June 2020) had an approximately threefold lower risk of death than those infected during the first wave. Thus, in a series of all confirmed SARS-CoV-2-infected cases in an entire European nation, elderly age was by far the most significant risk factor for COVID-19 mortality, confirming that protecting the elderly should be a priority in pandemic management. Male sex and being infected during the first wave were additional risk factors associated with COVID-19 mortality
"The love that made hell, paradise." Ouida re-writing the Paolo and Francesca theme in Held in Bondage
No full textThe bestselling Victorian author Ouida reveals in her novels, and, in particular, Held in Bondage, an extraordinary knowledge od Dante, by using characters and themes from the Commedia. The Paolo and Francesca theme actually constitutes part of the plot of the novel and is to be found in many of her other works, short stories and non-fiction writing
HERStory Makers 2023: Francesca Fotheringham
No full textFrancesca Fotheringham is a postdoctoral research associate at the University of Edinburgh studying educational psychology with a focus on neurodiversity. She took part in HERStory Makers 2023.What is HERStory Makers?HERStory Makers is a social media competition for female-identifying early career researchers to share their research, their career journeys, and to inspire the next generation. Winners are selected by public vote. HERStory Makers is also part of EXPLORATHON, Scotland's contribution to European Researchers' Night.In 2022-23, EXPLORATHON Francescasupported by the Engineering & Physical Sciences Research Council [grant number EP/X020762/1].Author contributions to contentFrancesca conceived, planned, and recorded the video content. Kirsty Ross edited the video content to insert HERStory Maker credits, added subtitles, and reduce video length to below Twitter/X limit of 2 mins and 20 secs.</p
Medicina illuminata. La Biblioteca Lancisiana di Roma
No full textL'articolo presenta i codici miniati della Biblioteca Lancisiana di Roma. La prima parte, del coautore, è dedicata alla Biblioteca. La seconda parte, di F. Manzari, tratta dei manoscritti miniati, costituiti da due codici con le opere di Avicenna e dal Liber fraternitatis della Confraternita dell'Ospedale di Santo Spirito in Sassia a Roma.The article introduces the illuminated manuscripts of the Biblioteca Lancisiana in Rome. The first part of the article, by the co-author, is dedicated to the Library. The second part, by Francesca Manzari, illustrates the manuscipts; these are two manuscripts with the works of Avicenna and the Liber fraternitatis of the Confraternity of the Hospital of Santo Spirito in Sassia in Rome
A DH-Leavened Musicological Toolbox
No full textGraduate-level training in music research methodologies tends to ignore digital humanities work and overlook the use of digital tools created in support of new forms of reading. Training instead focuses on source material in the student’s area of interest. This material includes secondary and primary (archival) resources, as well as information resources, such as: monuments of music and critical editions; indexes; bibliographies and thematic catalogs; dictionaries and encyclopedias; digital libraries of scores or editions; and databases of period-specific newspapers or journals. Graduate students taking research methods courses already have a toolbox built from their experiences as musicians and students of music, including the ability to read and interpret music notation, to understand theoretical and analytical concepts in music, as well as a command of music history, including the canon of musical works.
Digital humanities has become a major area of academic endeavor at the “interface of technological development, epistemological change and methodological concerns." An important characteristic of digital humanities research has been its interdisciplinarity. We argue that graduate training in musicology needs to include coverage of methodologies applied by digital humanists in support of new forms of reading, not only to broaden the canon of research topics in musicology, but also to build common ground with researchers of other disciplines. We propose that librarians are well positioned to provide this expertise and training
A Twitter Case Study for Assessing Digital Sound
No full textAcademic and cultural heritage institutions around the world have made measurable strides in the development of digital sound archives oriented towards research and access, but their impact on scholarship and society has been little studied. Traditionally, impact has been measured by citations; yet these are problematic metrics for non-traditional outputs like sound recordings. Social media data provide a promising avenue of investigation for measuring scholarly as well as societal impact. Twitter in particular has been shown to provide a high number of references for cultural and research outputs in all disciplines. This study analyzes Twitter references pertaining to the collections of five digital sound archives: British Library Sounds, Europeana Sounds, the Internet Archive Audio Archive, PennSound and UbuWeb. Using text analysis methods to identify high frequency events and trends, and labeling them with a rubric designed for measuring the impact of digital heritage resources, this study provides preliminary insights on user values as they relate to digital sound collections. Despite the limitations of using social media data, the evidence gathered in this case study characterizes aspects of the use of digital sound collections, and may point to future priorities for the digital preservation of sound.Peer reviewe
Against the Grain: Reading for the Challenges of Collaborative DH Pedagogy
No full textThis article provides a critical review of the past five years of literature in digital humanities pedagogy and faculty-librarian collaboration, commingled with reflections on personal practice, which extend findings from the literature. Faculty-librarian partnerships in DH pedagogy reflect a rapidly evolving area of engagement calling for expertise in teaching, subject knowledge, scholarly communication, digital technologies, and DH research methodologies. Although there is a rapidly expanding body of literature on these partnerships, the challenges of the work tend to be minimized. This article expands upon commonly encountered difficulties, and it points to potential solutions and best practices.Peer reviewe
SoundCloud
No full textCan't get a clear policy on OA from Notes. Hoping an AM is okay. I can email Notes staff, if helpful
Le differenti gioventù del '68, in: Uguaglianze/differenze. Riflessioni per Anna Rossi-Doria
No full textIn questo articolo l’A. riassume i punti essenziali della sua ipotesi interpretativa a proposito della “generazione del 68”.
Convinta della necessità di decostruire questa categoria, Francesca Socrate si propone di analizzare il profilo sociale e culturale delle studentesse e degli studenti universitari che fecero parte del movimento focalizzando l’attenzione in primo luogo sulla loro età, per arrivare alla definizione di almeno due “generazioni sociali” che, per quanto separate da una ridotta distanza anagrafica, portano i segni di due culture tra loro distanti: la prima è quella dei nati durante gli anni della guerra; la seconda, quella dei nati tra il ‘46 e il ’51. Alla prima coorte generazionale appartengono la maggior parte dei leader del movimento studentesco, alla seconda ragazzi e ragazze più giovani che sono presenti nel movimento, spesso con un’alta intensità di partecipazione, ma in una posizione gregaria. L’A. mette in rilievo come questo rapporto sia nella sostanza solo apparente, dal momento che nell’intreccio fra le due componenti generazionali saranno i più giovani a imporre la loro cultura generazionale, non tanto nelle sue teorizzazioni ma nelle pratiche, mentre le parole, le parole chiave e le parole d’ordine, saranno trovate dalla prima generazione, quella dei nati durante gli anni della guerra.The Diverse Youth Groups of '68
In this paper, the author summarises the main points of her interpretative hypothesis regarding the "'68 generation".
A conviction of the need to deconstruct this category prompted Francesca Socrates to attempt an analysis of the social and cultural profiles of the male and female university students who were part of the movement, focusing principally upon their age in order to define at least two "social generations" which, though separated by only a few years, bear the marks of two widely divergent cultures: the first is that of those born during the Second World War, and the second that of those born between 1946 and 1951. The first generational group contained most of the leaders of the student movement, while the second contained younger people whose role in the movement, though often highly active, was principally that of adherents. The author highlights how this apparent relationship is essentially superficial, since in the interweaving of the two components it was the younger generation who would impose their generational culture, less in theoretical than in practical terms, while the words, the catchphrases and slogans would derive from the first generation, those born during the war years.
Keywords: generations; 19698; youth culture
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