16,353 research outputs found
Ming-Hui Lin, flute and Ayako Yoda, piano and harpsichord, April 25, 2015
No full textThis is the concert program of the Ming-Hui Lin, flute and Ayako Yoda, piano and harpsichord performance on Saturday, April 25, 2015 at 8:30 p.m., at the Marshall Room, 855 Commonwealth Avenue. Works performed were Sonata in C major for Flute and Basso Continuo, BWV 1033 by Johann Sebastian Bach, Sonata for Flute and Piano, No. 3 by Philippe Gaubert, Sonatina for Flute and Piano by Eldin Burton, Syrinx for Flute solo by Claude Debussy, and Introduction and Variations on "Trockne Blumen" in E minor for Flute and Piano, D802 by Franz Schubert. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
Transformation invariance in hand shape recognition
No full textIn hand shape recognition, transformation invariance is key for successful recognition. We propose a system that is invariant to small scale, translation and shape variations. This is achieved by using a-priori knowledge to create a transformation subspace for each hand shape. Transformation subspaces are created by performing principal component analysis (PCA) on images produced using computer animation. A method to increase the efficiency of the system is outlined. This is achieved using a technique of grouping subspaces based on their origin and then organising them into a hierarchical decision tree. We compare the accuracy of this technique with that of the tangent distance technique and display the result
Shipyard layout
No full textThesis (M.S.)--Massachusetts Institute of Technology, Dept. of Naval Architecture and Marine Engineering, 1946.An exact copy of this thesis, under the same title, was submitted to the Dept. of Naval Architecture and Marine Engineering, MIT, for the B.S. degree under the following authors: Chen-Ming Lin and Kuei Ling.Includes bibliographical references (leaves 232-234).by Lin Chen-Ming, Yeh Yu-Hu.M.S
sj-tif-2-ang-10.1177_00033197211033747 – Supplemental Material for Venous Thromboembolism and Critical Limb Events in Patients with Atrial Fibrillation: A Nationwide Population-Based Cohort Study
No full textSupplemental Material, sj-tif-2-ang-10.1177_00033197211033747 for Venous Thromboembolism and Critical Limb Events in Patients with Atrial Fibrillation: A Nationwide Population-Based Cohort Study by Ming-Shyan Lin, Chang-Min Chung, Mei-Yen Chen, Pao-Hsien Chu, Shih-Tai Chang, Teng-Yao Yang, Victor C-C Wu, Wey-Yil Lin and Yu-Sheng Lin in Angiology</p
sj-tif-1-ang-10.1177_00033197211033747 – Supplemental Material for Venous Thromboembolism and Critical Limb Events in Patients with Atrial Fibrillation: A Nationwide Population-Based Cohort Study
No full textSupplemental Material, sj-tif-1-ang-10.1177_00033197211033747 for Venous Thromboembolism and Critical Limb Events in Patients with Atrial Fibrillation: A Nationwide Population-Based Cohort Study by Ming-Shyan Lin, Chang-Min Chung, Mei-Yen Chen, Pao-Hsien Chu, Shih-Tai Chang, Teng-Yao Yang, Victor C-C Wu, Wey-Yil Lin and Yu-Sheng Lin in Angiology</p
sj-pdf-1-ang-10.1177_00033197211033747 – Supplemental Material for Venous Thromboembolism and Critical Limb Events in Patients with Atrial Fibrillation: A Nationwide Population-Based Cohort Study
No full textSupplemental Material, sj-pdf-1-ang-10.1177_00033197211033747 for Venous Thromboembolism and Critical Limb Events in Patients with Atrial Fibrillation: A Nationwide Population-Based Cohort Study by Ming-Shyan Lin, Chang-Min Chung, Mei-Yen Chen, Pao-Hsien Chu, Shih-Tai Chang, Teng-Yao Yang, Victor C-C Wu, Wey-Yil Lin and Yu-Sheng Lin in Angiology</p
LIN-39 promotes neuronal fate specification in the Q and V5 lineage.
No full text(A) The expression of lin-39 in AVM, SDQL/R, PDEL/R, and PVDL/R, indicated by the overlapping with neurotransmitter identity markers and specific fate markers (uIs115[mec-17p::TagRFP] for AVM, otIs181[dat-1p::mCh] for PDE, uIs117[lad-2p::mCh] for SDQ). (B) The expression of mab-5 in SDQL. (C) Summary of lin-39 (green) and mab-5 (cyan) expression in the descendants of Q and V5 lineages. (D) The loss of gcy-37 expression in AQR and AVM neurons in lin-39(n1760) mutants and the mispositioning of PQR in mab-5(gk670) mutants; the loss of lad-2 expression in SDQR in lin-39(n1760) mutants, the displacement of SDQL in mab-5(gk670) mutants, and the loss of lad-2 expression in both SDQs in lin-39(n1760) mab-5(e1239) mutants. The right panels show the penetrance for the loss of marker expression and cell body mispositioning. Mean ± SD for the percentage of cells showing corresponding phenotypes from three biological replicates are shown. Double asterisks indicate statistically significant difference (p Chi-square test. (E) The loss of ser-2 expression in PVD and PDE neurons and the loss of F49H12.4 expression in PVD in lin-39(n1760) and ceh-20(u843) mutants. (F) Dopaminergic marker dat-1 is normally expressed in PDE neurons in lin-39 mutants, but PDE shows axonal growth defects. The arrows indicate the termini of PDE axons. The expression of glutamatergic identity marker eat-4 and the PVD terminal selector gene mec-3 in PVD neurons in lin-39 mutants.</p
Spectrometric study of condensed phase species of thorium and palladium-based modifiers in a complex matrix for electrothermal atomic absorption spectrometry
No full textThe chemical and morphological transformations of condensed phase species of a thorium-based modifier were studied over the temperature range 200–2500 °C, without and with the presence of aluminium and silicon as matrix components, and in some instances, arsenic as an analyte element. A similar study was also conducted with palladium as the modifier, for comparison. Results were derived using scanning electron microscopy (SEM), energy dispersive (ED) X-ray spectrometry, Raman microanalysis and attenuated total reflectance (ATR) Fourier transform-infrared (FT-IR) spectrometry. Comparable results were found using pyrolytic and non-pyrolytic graphite platforms, with processes occurring at slightly higher temperatures on the pyrolytic graphite platform. With thorium as the modifier, metal oxides were the predominant species on the platform surface at relatively low temperatures (<1500 °C), whereas metal phases became prevalent at high temperatures, when thorium and aluminium tended to behave independently from one other. Some spatial variations in the composition of the salt residues on different regions of the platform were observed (from the region closest to the slot in the tube, to the region furthest from the slot). Nonetheless, thorium metal remained on the graphite platform to higher temperatures than did aluminium metal. In the presence of arsenic, the existence of mixtures of thorium and arsenic oxides, just before the appearance temperature of gas phase arsenic atoms, was confirmed by SEM studies, ED X-ray spectra and Raman microanalysis. This suggests that any modifying effect of thorium on arsenic occurs while the modifier is in the oxide phase rather than in the metal phase. The presence of silicon added as silica, did not influence significantly the thermochemical behaviour of mixtures of thorium and aluminium. However, coexistence of silicon and arsenic oxides at the appearance temperature of the atomic absorption signal of arsenic was obtained, confirming that silicon can act as an internal modifier for arsenic. In the presence of palladium, aluminium exhibited greater interaction with the modifier; consequently, aluminium metal was retained on the platform surface to higher temperatures than thorium, which could explain how interference effects of aluminium on e.g. arsenic are avoided or reduced. Similarly, there was evidence for interaction of palladium and arsenic in the reduced state. However, when aluminium and silicon were present, the transformation of the palladium oxide to the metallic state was affected, which could diminish the modifying benefits of palladium for arsenic in the presence of aluminium
High Corruption Income in Ming and Qing China
No full textWe develop an economic model that explains historical data on government corruption in Ming and Qing China. In our model, officials extensive powers result in corrupt income matching lands share in output. We estimate corrupt income to be between 14 to 22 times official income resulting in about 22% of agricultural output accruing to 0.4% of the population. The results suggest that eliminating corruption through salary reform was possible in early Ming but impossible by mid-Qing rule. Land reform may also be ineffective because officials could extract the same rents regardless of ownership. High officials incomes and the resulting inequality may have also created distortions and barriers to change that could have contributed to Chinas stagnation over the five centuries 1400-1900s.Corruption, China
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