2 research outputs found
Pallidal Beta Activity Is Linked to Stimulation‐Induced Slowness in Dystonia
No full textBackground
Pallidal deep brain stimulation (DBS) effectively alleviates symptoms in dystonia patients, but may induce movement slowness as a side-effect. In Parkinson's disease, hypokinetic symptoms have been associated with increased beta oscillations (13–30 Hz). We hypothesize that this pattern is symptom-specific, thus accompanying DBS-induced slowness in dystonia.
Methods
In 6 dystonia patients, pallidal rest recordings with a sensing-enabled DBS device were performed and tapping speed was assessed using marker-less pose estimation over 5 time points following cessation of DBS.
Results
After cessation of pallidal stimulation, movement speed increased over time (P < 0.01). A linear mixed-effects model revealed that pallidal beta activity explained 77% of the variance in movement speed across patients (P = 0.01).
Conclusions
The association between beta oscillations and slowness across disease entities provides further evidence for symptom-specific oscillatory patterns in the motor circuit. Our findings might help DBS therapy improvements, as DBS-devices able to adapt to beta oscillations are already commercially available. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Deutsche ForschungsgesellschaftCharité‐Universitätsmedizin BerlinBerlin Institute of Health at Charité (BIH) http://dx.doi.org/10.13039/501100017268SPOKES Wellcome Trust Funded Translational Partnership Fellowshi
Multidimensional database configuration and usage possibilities for large-scale data analysis using Essbase platform
No full textBakalaura darbā tiek aprakstīts un analizēts eksistējošs Zviedrijas bankas Hyperion Essbase lielapjoma datu apstrādes risinājums, ar mērķi izpētīt problēmas, ar kurām nākas saskarties ikdienas darbā, un piedāvāt iespējamos problēmu risinājumus.
Lai īstenotu darba mērķi, tiek veikta tiešsaistes analītiskās apstrādes tehnoloģijas izpēte, kā arī noteiktas tās priekšrocības un trūkumi. Tiek sniegts ieskats Hyperion Essbase platformā, uz kuras balstās ieviestais risinājums, kā arī tiek aprakstīta lielu uzņēmumu analītikas būtība, lai attēlotu saikni starp tehnisko un funkcionālo pusēm.
Par izpētes metodēm kalpoja autores empīriskā pieredze, kas tika iegūta, piedaloties starptautiskos IT izstrādes projektos, kā arī darbs ar dažādiem informācijas avotiem.This thesis is dedicated to analysis of the existing Hyperion Essbase Business Intelligence large - scale solution which is used by a Swedish bank. The main objective is to identify existing technical issues and present a set of recommendations and instructions that could help to resolve them.
In order to achieve designated objectives, author explored online analytical processing technology and its main advantages and disadvantages. An overview regarding Hyperion Essbase platform and Enterprise Level analytics has been provided to highlight how technical and functional parties are connected to each other.
Author used various thematic literature sources and her own empirical experience, gained during participation in international software development projects, to achieve declared targets
